The OS-01 peptide reduces senescent burden / senescent cells / cellular senescence in skin.

The OS-01 peptide slows the progression of senescence, thereby reducing SASP-secreting cells and preventing the spread and accumulation of senescence in skin.

The OS-01 peptide promotes an increase in epidermal thickness (of up to +28%).

The OS-01 peptide likely improves skin’s barrier function by promoting increased epidermal thickness.

• Participants displayed a significant positive shift of the microbiome grade after treatment compared to baseline
• No significant changes in the ratio of bacteria to fungi were detected after treatment compared to baseline

Shown in lab studies on human skin samples by measuring epidermal thickness in skin treated with nothing, OS-01 FACE, or 1% topical retinol for 5 days. Skin treated with OS-01 FACE displayed a significant increase compared to skin with no treatment, while skin treated with retinol displayed no change compared to skin with no treatment. (Zonari, A., et al. npj Aging, 2023, supplementary information)

Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

Note: These results represent acute responses to the products and may not reflect long-term results.

Shown in lab studies on ex vivo human eyelid skin samples (42, 59, 84 yr) by measuring key collagen degradation biomarker, MMP1. Skin treated with OS-01 EYE displayed a significant decrease in MMP1 (p<0.05) compared to skin with no treatment.

NEA awards the Seal to products that are deemed suitable for people with eczema or sensitive skin, based on sensitivity, toxicity, and ingredient testing data. To learn more about the Seal, click here. You can find OS-01 BODY on the NEA Seal Product Directory here. RIPT study was performed on 114 participants.

• Fitzpatrick Types I-II (n=28):
  • 78% agreed product matched seamlessly
  • 14% thought product was too dark
• Fitzpatrick Types III-IV (n=4):
  • 75% agreed product matched seamlessly
  • 25% thought product was too dark
• Fitzpatrick Types V-VI (n=6):
  • 33% thought tint was too light
  • 66% agreed tint matched seamlessly

• Fitzpatrick Types I-II (n=16):
  • 69% agreed no white cast
  • 18% reported a white cast
• Fitzpatrick Types III-IV (n=7):
  • 100% agreed no white cast
• Fitzpatrick Types V-VI (n=8):
  • 37.5% agreed no white cast
  • 37.5% reported a white cast

OS-01 HAIR significantly increases hair density. (Shown in 86.67% of participants with an average improvement of 39.62% after 6 months.)

70% of users experienced an increase in hair density within 3 months. (Shown in 70% of participants with an average improvement of 9.97% after 3 months.)

Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram.

- After 3 months, 70% of participants experienced a 9.97% average decrease in inter follicular mean distance. ( **p < 0.01)

- After 6 months, 86.67% of participants experienced a 39.62% average increase in hair count per cm2. (****p < 0.0001)

- Participants saw a significant increase in hair count per cm2 between 3 and 6 months (**p < 0.01)

6 out of 7 (85.71%) men experienced an average increase of 34.86% in hair density after 6 months of using OS-01 HAIR.

Shown in 6 month double-blind, independent, third-party clinical study with 7 male participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram. After 6 months, 85.71% of male participants experienced a 34.86% average increase in hair count per cm2. (*p < 0.05)

Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram.

- After 6 months, 83.33% of participants experienced a 42.58% average increase in hair thickness (sum of hair widths). (****p < 0.0001)

- Participants saw a significant increase in hair thickness (sum of hair widths) between 3 and 6 months (**p < 0.01)

100% of men experienced an average increase of 36.68% in hair thickness after 6 months of using OS-01 HAIR.

6 out of 7 men experienced an average increase of 28.42% increase in hair thickness within 3 months.

Shown in 6 month double-blind, independent, third-party clinical study with 7 male participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram.

- After 3 months, 85.71% of male participants experienced a 28.42% average increase in hair thickness (sum of hair widths). (*p < 0.05)

- After 6 months, 100% of male participants experienced a 36.68% average increase in hair thickness (sum of hair widths). (***p < 0.001)

OS-01 HAIR can reactivate the natural hair-growth cycle. (Based on significant increase in anagen hairs.)

OS-01 HAIR significantly increases anagen (growth phase) hairs. (Shown in 73.33% of participants with an average improvement of 42.39% after 6 months)

Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram.

- After 6 months, 73.33% of participants experienced a 42.39% average increase in anagen hairs per cm2. (***p < 0.001)

- Participants saw a significant increase in anagen hairs per cm2 between 3 and 6 months (*p < 0.05)

6 out of 7 (85.71%) men experienced an average increase of 35.42%% in anagen (growth-phase) hairs within 6 months. 

6 out of 7 (85.71%) men experienced an average increase of 20.19% in anagen (growth-phase) hairs within 3 months.

6 out of 7 men had their hair growth cycle return to a healthier state within 3 months. (Base don increase in anagen hairs.)

Shown in 6 month double-blind, independent, third-party clinical study with 7 male participants using OS-01 HAIR twice daily and dermarolling once daily. Hair parameters measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram.

- After 3 months, 85.71% of male participants experienced a 20.19% average increase in anagen hairs. (*p < 0.05)

- After 6 months, 85.71% of male participants experienced a 35.42% average increase in anagen hairs. (*p < 0.05)

OS-01 HAIR is clinically validated to support the scalp microbiome.

Clinically shown to support a healthier scalp microbiome by increasing M. globosa abundance, resulting in a lower M. restricta / M. globosa ratio — a key marker associated with reduced dandruff and improved scalp health (Saxena et al., 2018; Ergin et al., 2024)

Shown in a 6-month clinical study performed by a third party research organization (HelloBiome) with 30 participants who collected samples of their scalp microbiome before and after treatment with OS-01 HAIR for 6 months. Using next generation sequencing and existing research, HelloBiome determined that OS-01 HAIR supports skin’s microbiome because:

- Participants displayed significant positive changes in bacterial diversity (significant increase in bacterial diversity, significant decrease in species known to increase with hair loss, and significant increase in species known to decrease with hair loss)

- No significant changes in the fungal diversity were detected after treatment compared to baseline

3 Months:

80.00% observed improvements in their hair

76.67% observed improvement in the overall health of the hair

70.00% said that existing hair is growing faster

73.33% said that the hair appears fuller

70.00% said that their scalp feels more nourished

6 Months: 

70.00% said existing hair grew faster

76.67% said the overall health of their hair improved

73.33% reported decreased shedding

83.33% said their hair felt nourished

70% reported thicker hair

73.33% reported stronger hair

70% said hair's natural texture was enhanced

Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR twice daily and a dermaroller once daily. Results based on self-perception reporting.

Immediately

89.47% agreed they were able to style hair like usual

85% agreed the product is lightweight

2 Months:

80.95% agreed their scalp was more hydrated after 2 months

3 Months:

81.82% noticed new hair growth after 3 months

72.73% saw visibly denser hair (more hairs on their heads) after 3 months

OS-01 HAIR is the first scalp serum with the OS-01 peptide, scientifically formulated to target cellular senescence—a biological process linked to hair loss and thinning.

OS-01 HAIR is the first scalp serum with the OS-01 peptide, scientifically formulated to target cellular senescence—a key driver of age-related hair loss & thinning.

Based on lab studies showing that the OS-01 peptide significantly reduces cellular senescence in skin (Zonari, et al, npj Aging, 2023) and that OS-01 HAIR significantly reduces senescence in stressed hair follicle cells (ORSCs).

Shin, Wisoo et al. Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss. Developmental Cell, 53(2), 185 - 198. 2020
https://www.sciencedirect.com/science/article/pii/S1534580720302318

• 97.87% agree OS-01 LIP SPF applies smoothly

• 94% agree OS-01 LIP SPF offers easy-to-use packaging on-the-go

• 92% agree OS-01 LIP SPF delivers immediate hydration & moisture

• 89.36% agree the applicator feels high-quality and easy to use

• 88% agree OS-01 LIP SPF makes their lips feel soothed and protected

• 87.23% agree OS-01 LIP SPF quickly hydrates for instant relief

• 86.67% agree OS-01 LIP SPF blends seamlessly with their skin tone once absorbed

• 84% agree OS-01 LIP SPF reapplies smoothly without any unpleasant buildup

• 84% agree their lips felt nourished after two weeks

• 82.61% agree OS-01 LIP SPF quickly soothes chapped lips

• 80% agree OS-01 LIP SPF works well under makeup

• 78% agree OS-01 LIP SPF provides long-lasting hydration & moisture (2+ hours)

• 77.5% agree OS-01 LIP SPF does not have an unpleasant taste

Blendability based on skin tone (% agree OS-01 LIP SPF blends seamlessly with their skin tone once absorbed)

Fitzpatrick Type I (n=7): 85.71%

Fitzpatrick Type II (n=8): 87.50%

Fitzpatrick Type III (n=11): 90.91%

Fitzpatrick Type IV (n=10): 90.00%

Fitzpatrick Type V (n=8): 75.00%

Fitzpatrick Type VI (n=1): 100.00%

OS-01 LIP SPF protects skin from UV-induced damage by reducing:

• UV-induced inflammation biomarker (IL-8) by 103.1%

• UV-induced tissue damage biomarker (MMP3) by 86.7%

• UV-induced senescence/aging biomarker (CDKN1A/P21) by 103.5%

Shown in lab studies on ex vivo human skin samples by measuring the gene expression level of IL-8 (inflammation), MMP3 (extracellular matrix degradation), and CDKN1A/p21 (senescence/aging) in the epidermis before and 24 hours after UVB exposure. Skin that was treated with OS-01 LIP SPF displayed significant decreases (103.1% lower IL-8 levels*, 86.7% lower MMP3 levels**, and 103.5% lower CDKN1A/P21 levels*) compared to skin that was not treated. (n=3 donors) (*p<0.05; **p<0.01)

OS-01 LIP SPF significantly increases a key elastin production biomarker (ELN) by +47%.

OS-01 LIP SPF significantly increases epidermal thickness.