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OS-01 Peptide

OS-01 FACE MOISTURIZER

OS-01 RICH FACE CREAM

OS-01 EYE CREAM

OS-01 HAIR SCALP SERUM

OS-01 LIP MASK

OS-01 LIP SPF

OS-01 FACE SPF

OS-01 BODY SPF

OS-01 BODY

FACE CLEANSER (PREP)

OS-01 Peptide™

OS-01 Peptide™ — Lab Data
Category	Claim	Details
Biological Age	The OS-01 Peptide™ reverses skin's biological age.	Based on ex vivo lab studies measuring epigenetic markers and using a skin-specific molecular clock which indicate skin's biological age (Zonari et al., npj Aging, 2023; Boroni et al., Clinical Epigenetics, 2020). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Cellular Senescence	The OS-01 Peptide™ reduces senescence in skin. The OS-01 Peptide™ reduces SASP-secreting cells, slowing the spread and accumulation of senescence in skin.	Based on ex vivo and in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Repair	The OS-01 Peptide™ supports skin's natural repair processes.	Based on in vitro lab studies measuring cellular damage biomarker, γH2A.x, and evaluating PP2A, involved in cellular repair, which indicate repair processes (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
UV-induced senescence / UV aging	The OS-01 Peptide™ reduces/prevents UV-induced senescence / UV aging in skin by 42.5%.	Based on in vitro lab studies measuring levels of senescence before and after UVB exposure which indicate UV-induced senescence and aging (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
UV-induced inflammation	The OS-01 Peptide™ reduces/prevents UV-induced inflammation biomarkers in skin.	Based on in vitro lab studies measuring inflammation biomarkers (IL-6 and CCL2) before and after UVB exposure which indicate UV-induced inflammation (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Dark Spots	The OS-01 Peptide™ targets the appearance of dark spots at the cellular level.	Based on in vitro lab studies measuring melanin which indicate the appearance of dark spots (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Inflammation	The OS-01 Peptide™ reduces a key inflammation biomarker in skin.	Based on ex vivo lab studies measuring inflammation biomarker (IL-6) which indicate inflammation (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Hyaluronic Acid	The OS-01 Peptide™ increases a key hyaluronic acid production biomarker in skin by 246% / promotes hyaluronic acid production in skin by 246%.	Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Collagen	The OS-01 Peptide™ increases a key collagen production biomarker in skin by 179% / promotes collagen production in skin by 179%.	Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Keratin	The OS-01 Peptide™ increases key keratin production biomarkers in skin / promotes keratin production in skin.	Based on ex vivo lab studies measuring keratin production biomarkers (KRT1 and KRT14) which indicate keratin production (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Senescence in hair	The OS-01 Peptide™ targets senescence in hair. The OS-01 Peptide™ significantly reduces a key senescence biomarker in stressed hair cells.	Based on in vitro lab studies measuring senescence biomarker (CDKN1A/P21) which indicate senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 Peptide™ — Clinical Data
Category	Claim	Details
Skin barrier & hydration retention	The OS-01 Peptide™ improves skin barrier strength/hydration retention after 6 weeks. After 6 weeks, the side treated with the OS-01 formulation showed nearly 4 times greater improvement in skin barrier strength/hydration retention than the control side.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and measured with a vapometer. Effects of the peptide were isolated by evaluating the difference in barrier function between skin treated with OS-01 FACE MOISTURIZER versus an identical formulation without the OS-01 Peptide (vehicle formulation). A significant improvement was observed between skin treated with OS-01 FACE MOISTURIZER versus the vehicle formulation (18.9% vs. 5.0% reduction in TEWL loss from baseline; p=0.012). (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Skin texture	The OS-01 Peptide™ improves/smooths skin texture after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and measured with an Antera 3D. Effects of the peptide were isolated by evaluating the difference in texture between skin treated with OS-01 FACE MOISTURIZER versus an identical formulation without the OS-01 Peptide (vehicle formulation). A significant improvement was observed between skin treated with OS-01 FACE MOISTURIZER versus the vehicle formulation (p=0.030). (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).

OS-01 FACE MOISTURIZER

OS-01 FACE MOISTURIZER — Lab Data
Category	Claim	Details
Aging/senescence	OS-01 FACE MOISTURIZER reduces key aging/senescence biomarkers in skin.	Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A and B2M) which indicate senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Collagen	OS-01 FACE MOISTURIZER increases a key collagen production biomarker in skin y 51% / promotes collagen production in skin by +51%.	Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
OS-01 FACE MOISTURIZER vs Retinol – Collagen	OS-01 FACE MOISTURIZER and retinol both increase a key collagen production biomarker in skin / promote collagen production in skin in the acute phase of treatment.	Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicates collagen production (Zonari, A., et al. npj Aging, 2023). These results represent acute responses to the products after 5 days of exposure, and may not reflect long-term results. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
OS-01 FACE MOISTURIZER vs Retinol – Aging/Senescence	Retinol increases a key aging/senescence biomarker more than 10-fold in the epidermis versus untreated skin, while OS-01 FACE MOISTURIZER significantly reduces it, in the acute phase of treatment.	Based on ex vivo lab studies measuring senescence biomarker (CDKN2A) which indicates senescence (Zonari, A., et al. npj Aging, 2023). These results represent acute responses to the products after 5 days of exposure, and may not reflect long-term results. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 FACE MOISTURIZER — Clinical Data
Category	Claim	Details
Skin barrier	OS-01 FACE MOISTURIZER improves skin barrier strength/resilience by 19% after 6 weeks, shown in 81% of users. OS-01 FACE MOISTURIZER improves skin barrier strength/resilience by 14% after 12 weeks, shown in 80% of users.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and measured with a vapometer. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Hydration retention	OS-01 FACE MOISTURIZER improves skin hydration retention in 81% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and measured with a vapometer.(Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Elasticity	OS-01 FACE MOISTURIZER improves skin elasticity in 68% of users after 6 weeks. OS-01 FACE MOISTURIZER improves skin elasticity in 91% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader tactile evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Skin tone	OS-01 FACE MOISTURIZER evens skin tone in 55% of users after 6 weeks. OS-01 FACE MOISTURIZER evens skin tone in 96% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Radiance	OS-01 FACE MOISTURIZER improves visible radiance in 96% of users after 12 weeks. OS-01 FACE MOISTURIZER improves skin radiance by +17% after 12 weeks, shown in 73% of users.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Pores	OS-01 FACE MOISTURIZER reduces the look of pores in 77% of users after 6 weeks. OS-01 FACE MOISTURIZER reduces the look of pores in 96% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Firmness	OS-01 FACE MOISTURIZER improves visible firmness in 91% of users after 6 weeks. OS-01 FACE MOISTURIZER improves visible firmness in 96% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Fine lines & wrinkles	OS-01 FACE MOISTURIZER reduces the appearance of fine lines and wrinkles in 55% of users after 6 weeks. OS-01 FACE MOISTURIZER reduces the appearance of fine lines and wrinkles in 86% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Smoothness	OS-01 FACE MOISTURIZER improves visible skin smoothness / visibly smooths skin in 86% of users after 6 weeks. OS-01 FACE MOISTURIZER improves visible skin smoothness / visibly smooths skin in 100% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Overall appearance	OS-01 FACE MOISTURIZER improves overall appearance in 82% of users after 6 weeks. OS-01 FACE MOISTURIZER improves overall appearance in 100% of users after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65, and analyzed via double-blind expert clinical grader visual evaluation. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Skin microbiome	OS-01 FACE MOISTURIZER is clinically validated to support skin's microbiome. Participants displayed a significant positive shift of the microbiome grade after treatment compared to baseline. No significant changes in the ratio of bacteria to fungi were detected after treatment compared to baseline.	Shown in a 6-week clinical study performed by a third party research organization (HelloBiome) with 38 participants who collected samples of their facial skin microbiome before and after treatment with OS-01 FACE MOISTURIZER for 6 weeks. Using next generation sequencing and existing research, HelloBiome determined that OS-01 FACE MOISTURIZER supports skin's microbiome.
Non-comedogenic	OS-01 FACE MOISTURIZER is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 33 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 FACE MOISTURIZER is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 FACE MOISTURIZER has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT performed on 108 participants.

OS-01 FACE MOISTURIZER — Consumer Perception Data
Category	Claim	Details
Hydration	86% agreed their skin felt more hydrated after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Tone & Texture	82% agreed their skin felt and looked smoother and more even toned after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Radiance	77% agreed their skin looked more radiant after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Firmness/Elasticity	86% agreed their skin looked/felt firmer and more elastic after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65.(Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Overall Appearance	86% agreed the overall appearance of their skin improved after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024).
Dark spots	68% agreed their dark spots improved after 6 weeks.	Based on a third-party 6-week clinical study with 38 participants aged 40–60. Data unpublished.
Eye bags	68% agreed their eye bags improved after 6 weeks.	Based on a third-party 6-week clinical study with 38 participants aged 40–60. Data unpublished.
Acne & visible redness	52% agreed that skin issues such as acne and visible redness improved after 6 weeks.	Based on a third-party 6-week clinical study with 38 participants aged 40–60. Data unpublished.

OS-01 RICH FACE CREAM

OS-01 RICH FACE CREAM — Lab Data
Category	Claim	Details
Collagen / Density	OS-01 FACE RICH CREAM increases collagen by 28%. OS-01 FACE RICH CREAM increases skin density by +28%.	Based on ex vivo lab studies measuring levels of collagen. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Elastin	OS-01 FACE RICH CREAM promotes elastin production by 108% / increases a key elastin production biomarker by 108%.	Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Hyaluronic Acid	OS-01 FACE RICH CREAM promotes skin’s hyaluronic acid production by 77% / increases a key hyaluronic acid production biomarker by 77%.	Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Barrier proteins	OS-01 FACE RICH CREAM promotes a key barrier protein by 294% / increases a key barrier protein production biomarker by 294%.	Based on ex vivo lab studies measuring barrier protein production biomarker (KRT10) which indicate barrier protein production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 RICH FACE CREAM — Clinical Data
Category	Claim	Details
Hydration	OS-01 FACE RICH CREAM improves skin's hydration by 29%, shown in 79% of users, after 6 weeks OS-01 FACE RICH CREAM improves skin's hydration by 38%, shown in 97% of users, after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader tactile evaluation.
Barrier	OS-01 FACE RICH CREAM increases skin's barrier strength by 13% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and measured with a TEWL device.
Radiance	OS-01 FACE RICH CREAM improves skin's visible radiance by 30%, shown in 83% of users, after 6 weeks. OS-01 FACE RICH CREAM improves skin's visible radiance by 31%, shown in 86% of users, after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader visual evaluation.
Smoothness	OS-01 FACE RICH CREAM improves skin's visible smoothness by 33%, shown in 90% of users, after 6 weeks. OS-01 FACE RICH CREAM improves skin's smoothness by 37%, shown in 93% of users, after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader visual evaluation.
Firmness	OS-01 FACE RICH CREAM improves skin's visible firmness by 16% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader visual evaluation.
Overall Appearance	OS-01 FACE RICH CREAM improves skin's appearance by 10% after 6 weeks. OS-01 FACE RICH CREAM improves skin's appearance by 20% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader visual evaluation.
Fine Lines	OS-01 FACE RICH CREAM reduces the appearance of fine lines by 7% after 6 weeks. OS-01 FACE RICH CREAM reduces the appearance of fine lines by 12% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65, and analyzed via double-blind expert clinical grader visual evaluation.
Non-comedogenic	OS-01 FACE RICH CREAM is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 14 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 FACE RICH CREAM is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 108 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 FACE RICH CREAM has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT performed on 108 participants.

OS-01 RICH FACE CREAM — Consumer Perception Data
Category	Claim	Details
Hydration	92% agree it delivers deep, long-lasting hydration (8+ hours). 95% agree it is ultra-hydrating.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Hydration	100% reported improved hydration after 6 weeks. 93% reported improved hydration after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Radiance	97% saw more radiant skin after 6 weeks. 97% saw more radiant skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Smoothness	97% saw visibly smoother skin after 6 weeks. 97% saw visibly smoother skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Smoothness	87% agree skin feels smoother after 4 weeks.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Fine Lines & Wrinkles	97% saw a reduced appearance of fine lines and wrinkles after 6 weeks. 86% saw a reduced appearance of fine lines and wrinkles after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Softness	97% reported softer skin after 6 weeks. 93% reported softer skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Elasticity	93% saw improved visible elasticity after 6 weeks. 93% saw improved visible elasticity after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Firmness	93% saw visibly firmer skin after 6 weeks. 93% saw visibly firmer skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Overall Appearance	93% saw improved overall appearance after 6 weeks. 97% saw improved overall appearance after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Moisture Retention	93% agree their skin retains hydration better after 6 weeks. 93% agree their skin retains hydration better over time. 90% agree their skin retains hydration better after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Moisture Retention	87% agree skin retains hydration for longer after 4 weeks	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Skin health	86% agree their skin looks and feels healthier after 6 weeks. 86% agree their skin looks and feels healthier after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Skin health	85% agree skin feels healthier after 4 weeks. 86% agree skin feels healthier after 8 weeks.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Balanced & nourished	86% reported more balanced and nourished skin after 6 weeks. 90% reported more balanced and nourished skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Overall skin quality	79% reported improvements in overall skin quality after 6 weeks. 90% reported improvements in overall skin quality after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Dryness / dry patches	81% saw less dry patches after 6 weeks. 85% saw less dry patches after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Youthfulness	69% agree their skin looks, feels, and acts more youthful after 6 weeks. 83% agree their skin looks, feels, and acts more youthful after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Redness & Irritation	52% saw reduced visible redness and irritation after 6 weeks. 81% saw reduced visible redness and irritation after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Dark spots	48% reported reduced appearance of dark spots after 6 weeks. 79% reported reduced appearance of dark spots after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Plumpness	66% experienced plumper-feeling skin after 6 weeks. 79% experienced plumper-feeling skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Skin thickness / resilience	59% reported thicker, more resilient-feeling skin after 6 weeks. 79% reported thicker, more resilient-feeling skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Sensitivity / reactivity	59% reported less reactive or sensitive skin after 6 weeks. 72% reported less reactive or sensitive skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Even tone	62% saw a more even skin tone after 6 weeks. 68% saw a more even skin tone after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Lift	62% saw visibly lifted skin after 6 weeks. 66% saw visibly lifted skin after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Sagging	50% saw reduced visible sagging after 6 weeks. 62% saw reduced visible sagging after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
Texture	95% agree it feels rich and nourishing.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Oiliness	95% agree it does not leave skin oily.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Routine	92% agree it integrates seamlessly with their existing skincare routine.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Comforting	87% agree it deeply moisturizes and comforts dry skin.	Based on a 12-week consumer perception study with 39 participants aged 25-84.
Recommend	85% would recommend OS-01 FACE RICH CREAM t o others with dry, depleted, or mature skin.	Based on a 12-week consumer perception study with 39 participants aged 25-84.

OS-01 EYE CREAM

OS-01 EYE CREAM — Lab Data
Category	Claim	Details
Collagen Degradation	OS-01 EYE CREAM reduces a key collagen degradation biomarker in skin / helps reduce collagen breakdown in skin.	Based on ex vivo lab studies measuring collagen degradation biomarker (MMP1) which indicate collagen degradation (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Collagen	OS-01 EYE CREAM increases collagen by 2.3x (+130%).	Based on ex vivo lab studies measuring collagen (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Aging/senescence	OS-01 EYE CREAM reduces a key cellular senescence and aging biomarker in skin.	Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A) which indicate senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Inflammation	OS-01 EYE CREAM reduces a key inflammation biomarker in skin.	Based on ex vivo lab studies measuring inflammation biomarker (IL-8) which indicates inflammation (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 EYE CREAM — Clinical Data
Category	Claim	Details
Hydration	OS-01 EYE CREAM improves skin hydration. 1 month: Avg improvement of +20%, shown in 83% of users. 3 months: Avg improvement of +32%, shown in 88% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Hydration retention	OS-01 EYE CREAM improves skin hydration retention in 70% of users after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Elasticity	OS-01 EYE CREAM improves skin elasticity. 1 month: Avg improvement of +14%, shown in 77% of users. 3 months: Avg improvement of +26%, shown in 86% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Elasticity (visible)	OS-01 EYE CREAM improves visible elasticity. 6 months: Avg improvement of +23%, shown in 78% of users. 12 months: Avg improvement of +29%, shown in 76% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Firmness	OS-01 EYE CREAM improves skin firmness. 1 month: Avg improvement of +6%, shown in 68% of users. 3 months: Avg improvement of +10%, shown in 73% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Firmness (visible)	OS-01 EYE CREAM improves visible firmness. 6 months: Avg improvement of +19%, shown in 70% of users. 12 months: Avg improvement of +27%, shown in 72% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Skin barrier	OS-01 EYE CREAM improves skin barrier function/strength/resilience. 1 month: Avg improvement of +10%, shown in 61% of users. 3 months: Avg improvement of +17%, shown in 70% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Skin Tone	OS-01 EYE CREAM improves skin tone by 17% after 12 months, shown in 63% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Skin Texture	OS-01 EYE CREAM visibly improves / smooths skin texture by 22% after 12 months, shown in 70% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Radiance	OS-01 EYE CREAM improves visible radiance by 25% after 12 months, shown in 65% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Under-eye puffiness	OS-01 EYE CREAM visibly reduces under-eye puffiness. 1 month: Avg improvement of 8%, shown in 50% of users. 3 months: Avg improvement of 11%, shown in 59% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65.(Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Fine lines & wrinkles	OS-01 EYE CREAM reduces the appearance of fine lines and wrinkles. 1 month: Avg reduction of 6%, shown in 45% of users. 3 months: Avg reduction of 7%, shown in 59% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Fine lines & wrinkles (12 months)	OS-01 EYE CREAM reduces the appearance of fine lines and wrinkles. 12 months: Avg reduction of 18%, shown in 63% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Dark Circles	OS-01 EYE CREAM reduces the appearance of dark circles by 7% after 3 months, shown in 50% of users.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Pores	OS-01 EYE CREAM reduces the look of pores by 21% after 12 months, shown in 70% of users.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Non-comedogenic	OS-01 EYE CREAM is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 33 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 EYE CREAM is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 EYE CREAM has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 108 participants.

OS-01 EYE CREAM — Consumer Perception Data
Category	Claim	Details
Hydration	91% agreed their skin felt more hydrated after 1 month. 86% agreed their skin felt more hydrated after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Hydration (6 months)	96% agreed their skin felt more hydrated after 6 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Firmness/Elasticity	86% agreed their skin felt/looked firmer and more elastic after 1 month. 82% agreed their skin felt/looked firmer and more elastic after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Firmness/Elasticity (6 & 12 months)	96% agreed their skin felt/looked firmer and more elastic after 6 months. 95% agreed their skin felt/looked firmer and more elastic after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Tone & Texture	95% of users agreed their skin felt and looked smoother and more even toned after 1 month. 91% of users agreed their skin felt and looked smoother and more even toned after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Tone & Texture (6 & 12 months)	96% of users agreed their skin felt and looked smoother and more even toned after 6 months. 96% of users agreed their skin felt and looked smoother and more even toned after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Radiance	91% of users agreed their skin looked more radiant after 1 month. 86% of users agreed their skin looked more radiant after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Radiance (6 & 12 months)	96% of users agreed their skin looked more radiant after 6 months. 100% of users agreed their skin looked more radiant after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Dark spots	82% agreed their dark spots improved after 1 month. 77% agreed their dark spots improved after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Dark spots (6 & 12 months)	86% agreed their dark spots improved after 6 months. 86% agreed their dark spots improved after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Under-eye puffiness	68% agreed their under-eyes looked less puffy after 1 month. 77% agreed their under-eyes looked less puffy after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Eye bags	83% agreed the appearance of their eye bags improved after 6 months. 86% agreed the appearance of their eye bags improved after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.
Overall Appearance	91% agreed the overall appearance of their skin improved after 1 month. 95% agreed the overall appearance of their skin improved after 3 months.	Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025).
Overall Appearance (6 & 12 months)	96% agreed the overall appearance of their skin improved after 6 months. 100% agreed the overall appearance of their skin improved after 12 months.	Based on a third-party 12-month clinical study with 23 participants aged 47–60. Data unpublished.

OS-01 BODY MOISTURIZER

OS-01 BODY MOISTURIZER — Lab Data
Category	Claim	Details
Collagen	OS-01 BODY MOISTURIZER increases collagen production by +23%.	Based on ex vivo lab studies measuring pro-collagen, a precursor protein to collagen, which indicates collagen production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 BODY MOISTURIZER — Clinical Data
Category	Claim	Details
Hydration	OS-01 BODY MOISTURIZER improved skin hydration by 38% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).
Skin barrier	OS-01 BODY MOISTURIZER improves skin barrier function/strength/resilience by 41% after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).
OS-01 Peptide penetration into bloodstream	The OS-01 Peptide™ does not accumulate in the bloodstream when applied topically with OS-01 BODY MOISTURIZER.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).
Non-comedogenic	OS-01 BODY MOISTURIZER is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 33 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 BODY MOISTURIZER is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 BODY MOISTURIZER has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 114 participants.

OS-01 BODY MOISTURIZER — Consumer Perception Data
Category	Claim	Details
Hydration	71.43% agreed their body skin felt more hydrated after 4 weeks. 93% agreed their skin felt more hydrated after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).
Texture	68% agreed their body skin felt and looked smoother after 4 weeks. 70% of users agreed their skin felt and looked smoother after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).
General Appearance	70% agreed the general appearance of their skin improved after 12 weeks.	Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025).

OS-01 HAIR SCALP SERUM

OS-01 HAIR SCALP SERUM — Lab Data
Category	Claim	Details
Age-related thinning	OS-01 HAIR SCALP SERUM targets a root cause of age-related hair thinning – cellular senescence.	Based on ex vivo and in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Stress-related hair thinning	OS-01 HAIR SCALP SERUM reduces CRH-induced senescence. CRH is a stress hormone, therefore this data suggests that OS-01 HAIR SCALP SERUM may be a potential candidate for addressing stress-induced hair thinning.	Based on in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Pattern thinning	OS-01 HAIR SCALP SERUM targets a potentially exacerbating factor of pattern thinning – cellular senescence.	Based on in vitro lab studies measuring levels of senescence and senescence-associated biomarkers (CDKN2A/P16, CDKN1A/P21, H2A.J, CXCL8 and IL-6) which indicate reduction in senescence (Zonari, A., et al. npj Aging, 2023). Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Inflammation biomarkers	OS-01 HAIR SCALP SERUM significantly reduces a key inflammation biomarker.	Based on in vitro lab studies measuring inflammation biomarker (IL-6) which indicate inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 HAIR SCALP SERUM — Clinical Data
Category	Claim	Details
Hair Cycle	OS-01 HAIR SCALP SERUM supports a healthy hair cycle.	Shown in a 6 month double-blind, independent, third-party clinical study with 32 participants (23 F and 9 M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram. Data unpublished.
Hair Density	OS-01 HAIR SCALP SERUM increases hair density by +40% after 6 months, shown in 81% of users. OS-01 HAIR SCALP SERUM shows continued increase in hair density between 3 and 6 months (+15%).	Shown in a 6-month double-blind, independent, third-party clinical study with 32 participants (23 F and 9 M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram. After 6 months, 81% of participants experienced a 40% average increase in hair density (hair count per cm²) compared to baseline (p = 0.00003). Participants saw a significant 15% increase in hair density (hair count per cm²) between 3 and 6 months (p = 0.00167). Data unpublished.
Hair Thickness	OS-01 HAIR SCALP SERUM increases hair thickness by +43% after 6 months, shown in 78% of users. OS-01 HAIR SCALP SERUM shows continued increase in hair thickness between 3 and 6 months (+15%).	Shown in a 6-month double-blind, independent, third-party clinical study with 32 participants (23 F and 9 M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Hair parameters were measured using HairMetrix® clinical photography, Trichoscopy and Phototrichogram. After 6 months, 78% of participants experienced a 43% average increase in hair thickness (sum of hair widths) compared to baseline (p = 0.00001). Participants saw a significant 15% increase in hair thickness (sum of hair widths) between 3 and 6 months (p = 0.00115). Data unpublished.
Grey Hair	OS-01 HAIR SCALP SERUM can reduce the appearance of grey hair.	Shown in a 6-month double-blind, independent, third-party clinical study with 24 participants (23 F and 9 M), ages 27–55, with grey hair using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. After 6 months, 37% of participants experienced a significant improvement in the overall appearance of hair pigment (grey hair) compared to baseline, based on visual hair pigment (grey) grading by a trained clinical expert grader (p = 0.01). Data unpublished.
Scalp microbiome	OS-01 HAIR SCALP SERUM is clinically validated to support the scalp microbiome, with: significant increase in bacterial diversity, significant decrease in species known to increase with hair thinning, significant increase in species known to decrease with hair thinning. No significant changes in fungal diversity detected after treatment.	Based on a 6-month clinical study by a third-party research organization (HelloBiome) with 30 participants aged 25–55. Scalp microbiome samples collected before and after 6 months of OS-01 HAIR SCALP SERUM treatment, analyzed by next-generation sequencing. Data unpublished. Reference: Saxena et al., 2018; Ergin et al., 2024.
Sensitive skin	OS-01 HAIR SCALP SERUM is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 55 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 HAIR SCALP SERUM has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 105 participants.

OS-01 HAIR SCALP SERUM — Consumer Perception Data
Category	Claim	Details
Hair shedding	72% reported decreased visible shedding after 6 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Hair volume/fullness	75% said their hair appears fuller after 3 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
General improvements	81% observed visible improvements in their hair after 3 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Overall hair health	78% observed visible improvement in the overall health of their hair after 3 months and after 6 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
New hair	75% observed the appearance of new hair after 3 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Scalp nourishment	72% said their scalp feels more nourished after 3 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Hair nourishment	78% said their hair felt nourished after 6 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Hair strength	75% reported stronger hair after 6 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Perceived growth rate	72% said existing hair grew faster after 6 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Hair texture	72% said hair's natural texture was enhanced.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Styling	89% agreed they were able to style their hair like usual.	Based on a 3-month beta test (brand-led consumer perception study) with 22 participants aged 25–74 using OS-01 HAIR SCALP SERUM 1–2x daily (no dermaroller). Data unpublished.
Product texture	85% agreed the product is lightweight.	Based on a 3-month beta test (brand-led consumer perception study) with 22 participants aged 25–74 using OS-01 HAIR SCALP SERUM 1–2x daily (no dermaroller). Data unpublished.
Scalp hydration	81% agreed their scalp felt more hydrated after 2 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.
Hair density (perceived)	73% saw visibly denser hair (more hairs on their heads) after 3 months.	Based on a 6-month, double-blind, independent, third-party clinical study with 32 participants (23F, 9M), ages 27–55, using OS-01 HAIR SCALP SERUM twice daily and dermarolling once daily. Results based on self-reported participant perception. Data unpublished.

OS-01 LIP MASK

OS-01 LIP MASK — Lab Data
Category	Claim	Details
Collagen	OS-01 LIP MASK increases key collagen production biomarker in skin by +138% / promotes collagen production in skin by +138%.	Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Collagen (vs luxury lip mask)	OS-01 LIP MASK increases key collagen production biomarker (COL1A1) in skin by +101% more than a luxury award-winning lip mask / promotes collagen production in skin by +101% more than a luxury award-winning lip mask.	Based on ex vivo lab studies measuring collagen production biomarker (COL1A1) which indicate collagen production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Elastin	OS-01 LIP MASK increases key elastin production biomarker in skin by +133% / promotes elastin production in skin by +133%.	Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Elastin (comparative)	OS-01 LIP MASK increases key elastin production biomarker in skin / promotes elastin production in skin more than comparative products: +135% vs. leading drugstore lip product; +101% vs. market leading peptide lip treatment; +67% vs. luxury award-winning lip mask.	Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Hyaluronic Acid	OS-01 LIP MASK increases key hyaluronic acid production biomarker (HAS2) in skin by +51% / promotes hyaluronic acid production in skin by +51%.	Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Hyaluronic Acid (vs drugstore)	OS-01 LIP MASK increases key hyaluronic acid production biomarker (HAS2) in skin by +41% / promotes hyaluronic acid production in skin by +41% more than a leading drugstore lip product.	Based on ex vivo lab studies measuring hyaluronic acid production biomarker (HAS2) which indicate hyaluronic acid production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Senescence/aging	OS-01 LIP MASK decreases key senescence/aging biomarker compared to leading competitors: −17% vs. market leading peptide lip treatment; −17% vs. leading drugstore lip product.	Based on ex vivo lab studies measuring levels of senescence biomarker (CDKN1A/P21) which indicates senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 LIP MASK — Clinical Data
Category	Claim	Details
Non-comedogenic	OS-01 LIP MASK is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 34 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 LIP MASK is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 64 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 LIP MASK has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 107 participants.

OS-01 LIP MASK — Consumer Perception Data
Category	Claim	Details
Use	100% agreed OS-01 LIP MASK is enjoyable to use.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Hydration (instant)	98% agreed lips feel instantly hydrated and moisturized upon application.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Hydration (overnight)	98% agreed lips feel hydrated and moisturized the next morning (8+ hours after application).	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Hydration (instant + long-lasting)	98% agreed OS-01 LIP MASK delivers both instant and long-lasting hydration (8+ hours).	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Ultra-hydrating	95% agreed OS-01 LIP MASK is ultra-hydrating.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Hydration retention (4 weeks)	90% agreed lips retain hydration for longer after 4 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Hydration retention (12 weeks)	94% agreed lips retain hydration for longer after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Taste	98% agreed OS-01 LIP MASK does not have an off-putting taste.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Satisfaction	98% would recommend OS-01 LIP MASK to friends and family.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Tingly	95% agreed OS-01 LIP MASK is non-tingly.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Application	95% agreed OS-01 LIP MASK applies smoothly.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Moisturization	95% agreed OS-01 LIP MASK deeply moisturizes lips.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Dryness, damage	92% agreed OS-01 LIP MASK helps soothe visibly dry, damaged lips.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Smoothness	90% agreed lips feel and look smoother after 2 weeks. 95% agreed lips feel and look smoother after 4 weeks. 97% agreed lips feel and look smoother after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Softness	87% agreed lips feel softer after 2 weeks. 95% agreed lips feel softer after 4 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Health	93% agreed lips feel and look healthier after 4 weeks. 97% agreed lips feel and look healthier after 8 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Fine lines & wrinkles (around lips)	81% who applied OS-01 LIP MASK around their lip border reported reduced appearance of fine lines and wrinkles around their lips after 4 weeks. 81% who applied OS-01 LIP MASK around their lip border reported reduced appearance of fine lines and wrinkles around their lips after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Fine lines & wrinkles (on lips)	80% reported reduced appearance of fine lines and wrinkles on their lips after 4 weeks. 84% reported reduced appearance of fine lines and wrinkles on their lips after 8 weeks. 87% reported reduced appearance of fine lines and wrinkles on their lips after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Fullness	78% reported improved visible fullness after 4 weeks. 81% reported improved visible fullness after 8 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Overall appearance	88% agreed the overall appearance of lips improved after 8 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Resilience	81% agreed lips feel more resilient after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.
Lip color	72% agreed the natural color of their lips improved after 12 weeks.	Based on a 12-week beta test (brand-led consumer perception study) with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK. Data unpublished.

OS-01 LIP SPF

OS-01 LIP SPF — Lab Data
Category	Claim	Details
Effects of UV-induced stress	OS-01 LIP SPF (untinted) protects skin from the effects of UV-induced stress by reducing inflammation, degradation, and senescence/aging biomarkers in skin: UV-induced inflammation biomarker by 103% UV-induced degradation biomarker by 87% UV-induced senescence/aging biomarker by 104%	Based on ex vivo lab studies measuring levels of inflammation, degradation, and senescence/aging biomarkers (IL-8, MMP3, and CDKN1A/P21) before and after UVB exposure which indicate UV-induced skin stress. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Senescence/aging	OS-01 LIP SPF (untinted) reduces existing senescence and aging biomarkers: CDKN1A/P21 by −20% CDKN2A/P16 by −21%	Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A/P16 and CDKN1A/P21) which indicate reduction in existing senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Elastin	OS-01 LIP SPF (untinted) increases key elastin production biomarker by +47% / promotes elastin production in skin by +47%.	Based on ex vivo lab studies measuring elastin production biomarker (ELN) which indicate elastin production. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 LIP SPF — Clinical Data
Category	Claim	Details
Sensitive skin	OS-01 LIP SPF is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 59 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 LIP SPF has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 108 participants.

OS-01 LIP SPF — Consumer Perception Data
Category	Claim	Details
Untinted - Application (smooth)	98% agreed OS-01 LIP SPF (Untinted) applies smoothly.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Application (reapplies)	84% agreed OS-01 LIP SPF (Untinted) reapplies smoothly without any unpleasant buildup.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Packaging	94% agreed OS-01 LIP SPF (Untinted) offers easy-to-use packaging on-the-go.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Applicator	89% agreed the applicator feels high-quality and easy to use.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Hydration (immediate)	92% agreed OS-01 LIP SPF (Untinted) delivers immediate hydration & moisture.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Hydration (instant relief)	87% agreed OS-01 LIP SPF (Untinted) quickly hydrates for instant relief.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Hydration (long-lasting)	78% agreed OS-01 LIP SPF (Untinted) provides long-lasting hydration & moisture (2+ hours).	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Protection	88% agreed OS-01 LIP SPF (Untinted) makes their lips feel soothed and protected.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Blending	87% agreed OS-01 LIP SPF (Untinted) blends seamlessly with their skin tone once absorbed.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Blending (Fitzpatrick)	OS-01 LIP SPF (Untinted) blends seamlessly with skin tone once absorbed: Fitzpatrick Type I (n=7): 86% agree; Fitzpatrick Type II (n=8): 88% agree; Fitzpatrick Type III (n=11): 91% agree; Fitzpatrick Type IV (n=10): 90% agree; Fitzpatrick Type V (n=8): 75% agree; Fitzpatrick Type VI (n=1): 100% agree.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Nourishment	84% agreed their lips felt nourished after two weeks.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Dry, chapped lips	83% agree OS-01 LIP SPF quickly soothes chapped lips.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Makeup	80% agree OS-01 LIP SPF works well under makeup.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Untinted - Taste	78% agreed OS-01 LIP SPF (Untinted) does not have an unpleasant taste.	Based on a 4-week beta test (brand-led consumer perception study) with 45 participants aged 25–74 using OS-01 LIP SPF (Untinted) daily. Data unpublished.
Bare Blush - Texture (lightweight)	100% agreed OS-01 LIP SPF (Bare Blush) feels lightweight and comfortable.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Texture (non-sticky)	92% agreed OS-01 LIP SPF (Bare Blush) doesn't feel sticky or greasy.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Application	100% agreed OS-01 LIP SPF (Bare Blush) applies smoothly.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Ease of use	100% agreed OS-01 LIP SPF (Bare Blush) is easy to use throughout the day.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Hydration	96% agreed OS-01 LIP SPF (Bare Blush) delivers immediate hydration.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Chapped lips	96% agreed OS-01 LIP SPF (Bare Blush) soothes dry or chapped lips.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Softness	92% agreed their lips feel instantly softer and more supple.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Routine	92% agreed OS-01 LIP SPF (Bare Blush) fits seamlessly into their daily routine.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.
Bare Blush - Visible damage	92% agreed their lips look less dry and visibly damaged.	Based on a 2-week beta test (brand-led consumer perception study) with 26 participants aged 25–74 using OS-01 LIP SPF (Bare Blush) daily. Data unpublished.

OS-01 FACE SPF

OS-01 FACE SPF — Lab Data
Category	Claim	Details
UV-induced senescence	OS-01 FACE SPF protects against UV-induced senescence, superior to regular sunscreen.	Based on ex vivo lab studies measuring levels of senescence biomarker (P16 / CDKN2A) before and after UVB exposure which indicate UV-induced senescence and aging. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Senescence/aging	OS-01 FACE SPF reduces existing senescence/aging biomarkers in skin. OS-01 FACE SPF reduces effects of past aging in skin.	Based on ex vivo lab studies measuring levels of senescence biomarkers (CDKN2A/P16) which indicates reduction in senescence. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Inflammation biomarker	OS-01 FACE SPF reduces a key inflammation biomarker in skin.	Based on ex vivo lab studies measuring inflammation biomarker (IL-6) which indicate inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Antioxidant power	OS-01 FACE SPF scavenges free radicals 4x more effectively than a leading anti-aging antioxidant SPF moisturizer.	Based on lab studies measuring free radical scavenging which indicates antioxidant power. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Antioxidant power (vs vitamin C)	OS-01 FACE SPF performs similarly to common vitamin C serums at neutralizing free radicals.	Based on lab studies measuring free radical scavenging which indicates antioxidant power. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 FACE SPF — Clinical Data
Category	Claim	Details
Sunburn	OS-01 FACE SPF is more effective at protecting against UV-induced sunburn compared to a top dermatologist recommended brand.	Based on a third-party clinical study with 30 participants aged 25–65. Erythema and pigmentation levels measured before and 24 hours after UV exposure on skin protected with OS-01 FACE SPF vs. a top dermatologist recommended brand.
Dark spots	OS-01 FACE SPF is more effective at protecting against UV-induced dark spots compared to a top dermatologist recommended brand.	Based on a third-party clinical study with 30 participants aged 25–65. Erythema and pigmentation levels measured before and 24 hours after UV exposure on skin protected with OS-01 FACE SPF vs. a top dermatologist recommended brand.
Non-comedogenic	OS-01 FACE SPF is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 33 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 FACE SPF is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 FACE SPF has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 104 participants.

OS-01 FACE SPF — Consumer Perception Data
Category	Claim	Details
Moisture	91% agreed their skin felt moisturized after using OS-01 FACE SPF.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Nourishment	87% agreed their skin felt nourished after using OS-01 FACE SPF.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Spreadability	80% agreed OS-01 FACE SPF spreads easily.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Hydration	78% agreed their skin felt more hydrated after using OS-01 FACE SPF.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Blending	76% agreed OS-01 FACE SPF blends seamlessly.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Texture	76% agreed OS-01 FACE SPF is lightweight.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Absorption	73% agreed OS-01 FACE SPF absorbs easily.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Smoothness	71% agreed their skin felt and looked smoother after using OS-01 FACE SPF.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Radiance	71% agreed their skin appeared more radiant after using OS-01 FACE SPF.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Makeup compatibility	71% agreed OS-01 FACE SPF sits well under makeup.	Based on a third-party 30-day consumer perception study with 50 participants aged 20–59. Participants self-reported effects of OS-01 FACE SPF (untinted). Data unpublished.
Untinted - White Cast	OS-01 FACE SPF (Untinted) did not show white cast: Fitzpatrick Type I-II (n=16): 69% agree; Fitzpatrick Type III-IV (n=7): 100% agree; Fitzpatrick Type V-VI (n=8): 38% agree.	Based on a one-week beta test (brand-led consumer perception study) with 38 participants (Untinted), aged 25–84. Participants self-reported results after using OS-01 FACE SPF at least once daily for one week. Data unpublished.
Light/Medium - Skin tone match	OS-01 FACE SPF (Light/Medium) matched seamlessly: Fitzpatrick Type I-II (n=28): 78% agree; Fitzpatrick Type III-IV (n=4): 75% agree; Fitzpatrick Type V-VI (n=6): 66% agree.	Based on a one-week beta test (brand-led consumer perception study) with 31 participants (Light/Medium Tinted), aged 25–84. Participants self-reported results after using OS-01 FACE SPF at least once daily for one week. Data unpublished.

OS-01 BODY SPF

OS-01 BODY SPF — Lab Data
Category	Claim	Details
Collagen	OS-01 BODY SPF protects skin from UV-induced collagen degradation.	Based on ex vivo lab studies measuring levels of collagen before and after UVB exposure. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
UV-induced senescence/aging	OS-01 BODY SPF reduces UV-induced senescence / UV aging in skin.	Based on ex vivo lab studies measuring levels of senescence biomarker (P16) before and after UVB exposure which indicate UV-induced senescence and aging. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
UV-induced inflammation biomarker	OS-01 BODY SPF reduces a UV-induced inflammation biomarker in skin.	Based on ex vivo lab studies measuring levels of inflammation biomarker (IL-8) before and after UVB exposure which indicate UV-induced inflammation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
UV-induced hyaluronic acid degradation	OS-01 BODY SPF reduces a UV-induced hyaluronic acid degradation biomarker in skin.	Based on ex vivo lab studies measuring levels of hyaluronic acid degradation biomarker (HYAL1) before and after UVB exposure which indicate UV-induced hyaluronic acid degradation. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

OS-01 BODY SPF — Clinical Data
Category	Claim	Details
Sunburn	OS-01 BODY SPF is more effective at protecting against UV-induced sunburn compared to a market-leading mineral sunscreen and a top dermatologist recommended anti-aging sunscreen.	Based on a third-party clinical study with 26 participants aged 25–65. Erythema and pigmentation levels measured with a Chromameter before and 24 hours after UV exposure on skin protected with OS-01 BODY SPF, a popular mineral sunscreen, and a top dermatologist recommended anti-aging sunscreen. Data unpublished.
Dark spots	OS-01 BODY SPF is more effective at protecting against UV-induced dark spots compared to a market-leading mineral sunscreen and a top dermatologist recommended anti-aging sunscreen.	Based on a third-party clinical study with 26 participants aged 25–65. Erythema and pigmentation levels measured with a Chromameter before and 24 hours after UV exposure on skin protected with OS-01 BODY SPF, a popular mineral sunscreen, and a top dermatologist recommended anti-aging sunscreen. Data unpublished.
Non-comedogenic	OS-01 FACE SPF is non-comedogenic.	Based on a third-party 4-week single-blind clinical study with 33 participants assessing comedogenic potential via repeated occlusive cutaneous patch applications and follicular biopsy.
Sensitive skin	OS-01 FACE SPF is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	OS-01 FACE SPF has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 104 participants.

OS-01 BODY SPF — Consumer Perception Data
Category	Claim	Details
Application	100% agreed OS-01 BODY SPF applies evenly and smooth.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Texture	97% agreed OS-01 BODY SPF feels light and weightless on skin.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Texture (oily)	83% agreed OS-01 BODY SPF does not leave skin oily or greasy.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Pore clogging	93% agreed OS-01 BODY SPF does not visibly clog their pores.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Blending	93% agreed OS-01 BODY SPF blends seamlessly with their skin tone. Fitzpatrick Type I-IV (n=20): 100% agree; Fitzpatrick Type V-VI (n=10): 80% agree.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Routine	85% agreed OS-01 BODY SPF worked well with the rest of their skin routine.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.
Hydration	77% agreed their skin feels instantly hydrated upon application of OS-01 BODY SPF.	Based on a one-week beta test (brand-led consumer perception study) with 30 participants aged 25–84. Participants self-reported results after using OS-01 BODY SPF. Data unpublished.

FACE CLEANSER (PREP)

FACE CLEANSER (PREP) — Lab Data
Category	Claim	Details
Peptide Absorption	FACE CLEANSER can improve OS-01 Peptide™ absorption by 2.2x.	Based on ex vivo lab studies measuring peptide levels in skin which indicate absorption. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.
Hydration	Compared to using OS-01 FACE MOISTURIZER alone, FACE CLEANSER can significantly increase a key hydration biomarker (AQP3) when used prior to OS-01 FACE MOISTURIZER.	Based on ex vivo lab studies measuring hydration biomarker (AQP3) which indicate hydration. Lab findings may not reflect outcomes in human use and do not represent whole-body aging or medical claims.

FACE CLEANSER (PREP) — Clinical Data
Category	Claim	Details
Sensitive skin	FACE CLEANSER is suitable for sensitive skin & dermatologically tested.	Based on a third-party clinical study with 54 healthy volunteers assessed by means of repeated cutaneous occlusive patch applications.
Eczema	FACE CLEANSER has been awarded the National Eczema Association Seal of Acceptance™ by the National Eczema Association (NEA).	NEA Seal of Acceptance™ awarded by the National Eczema Association. RIPT study performed on 108 participants.