Is This The Root Cause of Aging?
6 min read
may 10, 2023
May 10,2023
LONGEVITY
Is This The Root Cause of Aging?
6 min read
may 10, 2023
May 10,2023
LONGEVITY
Why do we age? It’s a question that has fascinated scientists for centuries. As longevity researchers discover more about the aging process, it’s becoming clear that all aging has certain cellular phenomena in common. Called the twelve hallmarks of aging, these phenomena are responsible for everything from the wrinkles we start to see in our 20s to the age-related diseases that plague us in old age.Recently, research has shown that one of these twelve hallmarks stands above the rest: cellular senescence, a central aging marker that activates a number of the other eleven hallmarks. Cellular senescence is so integral to the aging process that it links both major types of aging: intrinsic and extrinsic aging. Let’s take a closer look at the science behind these discoveries.
Why do we age? It’s a question that has fascinated scientists for centuries. As longevity researchers discover more about the aging process, it’s becoming clear that all aging has certain cellular phenomena in common. Called the twelve hallmarks of aging, these phenomena are responsible for everything from the wrinkles we start to see in our 20s to the age-related diseases that plague us in old age.Recently, research has shown that one of these twelve hallmarks stands above the rest: cellular senescence, a central aging marker that activates a number of the other eleven hallmarks. Cellular senescence is so integral to the aging process that it links both major types of aging: intrinsic and extrinsic aging. Let’s take a closer look at the science behind these discoveries.
01
The difference between extrinsic and intrinsic aging
Determined largely by your genetics, intrinsic aging is the predetermined process that your body will undergo over time based on its innate ability to repair damage. This type of aging is beyond your control–and the reason you might notice similarities in the way your family members age.While intrinsic aging is out of your hands, extrinsic aging occurs as a result of external and often preventable environmental and lifestyle factors. Common extrinsic agers include UV exposure, smoking cigarettes, and sedentary lifestyles. It’s extrinsic aging we have to thank for the fact that siblings or other close family members sometimes age at very different rates and in very different ways.
01
The difference between extrinsic and intrinsic aging
Determined largely by your genetics, intrinsic aging is the predetermined process that your body will undergo over time based on its innate ability to repair damage. This type of aging is beyond your control–and the reason you might notice similarities in the way your family members age.While intrinsic aging is out of your hands, extrinsic aging occurs as a result of external and often preventable environmental and lifestyle factors. Common extrinsic agers include UV exposure, smoking cigarettes, and sedentary lifestyles. It’s extrinsic aging we have to thank for the fact that siblings or other close family members sometimes age at very different rates and in very different ways.
02
Is This The Root Cause of Aging?
Determined largely by your genetics, intrinsic aging is the predetermined process that your body will undergo over time based on its innate ability to repair damage. This type of aging is beyond your control–and the reason you might notice similarities in the way your family members age.While intrinsic aging is out of your hands, extrinsic aging occurs as a result of external and often preventable environmental and lifestyle factors. Common extrinsic agers include UV exposure, smoking cigarettes, and sedentary lifestyles. It’s extrinsic aging we have to thank for the fact that siblings or other close family members sometimes age at very different rates and in very different ways.
02
Is This The Root Cause of Aging?
Determined largely by your genetics, intrinsic aging is the predetermined process that your body will undergo over time based on its innate ability to repair damage. This type of aging is beyond your control–and the reason you might notice similarities in the way your family members age.While intrinsic aging is out of your hands, extrinsic aging occurs as a result of external and often preventable environmental and lifestyle factors. Common extrinsic agers include UV exposure, smoking cigarettes, and sedentary lifestyles. It’s extrinsic aging we have to thank for the fact that siblings or other close family members sometimes age at very different rates and in very different ways.
03
Both intrinsic & extrinsic factors increase cellular senescence
We know that when the body experiences an extrinsic or intrinsic stimulus, aging occurs. But why? Scientists believe that both extrinsic and intrinsic factors activate cellular senescence, the accumulation of zombie cells at the end of their lifecycle that accelerate aging in the cells around them.Research has shown that intrinsic factors–like the activation of certain genes–can contribute to the accumulation of senescent cells. Similarly, extrinsic factors like radiation and or cigarette smoke can cause cells to enter senescence.
03
Both intrinsic & extrinsic factors increase cellular senescence
We know that when the body experiences an extrinsic or intrinsic stimulus, aging occurs. But why? Scientists believe that both extrinsic and intrinsic factors activate cellular senescence, the accumulation of zombie cells at the end of their lifecycle that accelerate aging in the cells around them.Research has shown that intrinsic factors–like the activation of certain genes–can contribute to the accumulation of senescent cells. Similarly, extrinsic factors like radiation and or cigarette smoke can cause cells to enter senescence.
04
Extrinsically induced senescent cells active intrinsic aging
While extrinsic and intrinsic aging are often thought of as separate, it’s clear that they actually intersect. Research has shown that external aging factors actually increase the rate at which we experience intrinsic aging. Scientists believe that cellular senescence may be the factor that links the two together.Extrinsic aging factors induce early senescence in cells, causing the body to act older than it actually is. With increasing exposure to these factors, the body can no longer keep up with the rate of senescence occurring–leading to an accumulation of senescent cells. These senescent cells secrete a wide range of factors collectively called the senescence-associated secretory phenotype (SASP). This is where the link to intrinsic aging comes into play. SASP itself can actually activate intrinsic aging – inducing inflammation, altering tissue homeostasis and promoting cellular dysfunction. This means that increasing rates of extrinsic aging can actually contribute to increasing rates of intrinsic aging through cellular senescence. When both extrinsic and intrinsic aging increase, we experience earlier onset of age-related diseases. For example, the accumulation of senescent cells in the brain can impair cognitive function and contribute to neurodegenerative diseases such as Alzheimer's.
04
Extrinsically induced senescent cells active intrinsic aging
While extrinsic and intrinsic aging are often thought of as separate, it’s clear that they actually intersect. Research has shown that external aging factors actually increase the rate at which we experience intrinsic aging. Scientists believe that cellular senescence may be the factor that links the two together.Extrinsic aging factors induce early senescence in cells, causing the body to act older than it actually is. With increasing exposure to these factors, the body can no longer keep up with the rate of senescence occurring–leading to an accumulation of senescent cells. These senescent cells secrete a wide range of factors collectively called the senescence-associated secretory phenotype (SASP). This is where the link to intrinsic aging comes into play. SASP itself can actually activate intrinsic aging – inducing inflammation, altering tissue homeostasis and promoting cellular dysfunction. This means that increasing rates of extrinsic aging can actually contribute to increasing rates of intrinsic aging through cellular senescence. When both extrinsic and intrinsic aging increase, we experience earlier onset of age-related diseases. For example, the accumulation of senescent cells in the brain can impair cognitive function and contribute to neurodegenerative diseases such as Alzheimer's.
05
The quest to address the root cause of aging
While extrinsic and intrinsic aging are often thought of as separate, it’s clear that they actually intersect. Research has shown that external aging factors actually increase the rate at which we experience intrinsic aging. Scientists believe that cellular senescence may be the factor that links the two together.
05
The quest to address the root cause of aging
While extrinsic and intrinsic aging are often thought of as separate, it’s clear that they actually intersect. Research has shown that external aging factors actually increase the rate at which we experience intrinsic aging. Scientists believe that cellular senescence may be the factor that links the two together.
Key Takeaways:
- All aging is either intrinsic, caused by internal factors like genetics, or extrinsic, mediated by external stimuli like UV radiation and toxins.
- By increasing cellular senescence, UV radiation accelerates skin aging and leads to the degradation of collagen and elastin.
- Both extrinsic and intrinsic factors activate cellular senescence, a central hallmark of aging that accelerates aging in neighboring cells.
- Extrinsically induced senescent cells release factors that activate intrinsic aging, creating a connection between intrinsic and extrinsic aging.
- This connection accelerates systemic aging and contributes to the early onset of age-related disease.
- By addressing cellular senescence as the root cause of aging, longevity scientists like those on our team hope to make age-related disease a thing of the past.
Key Takeaways:
- All aging is either intrinsic, caused by internal factors like genetics, or extrinsic, mediated by external stimuli like UV radiation and toxins.
- By increasing cellular senescence, UV radiation accelerates skin aging and leads to the degradation of collagen and elastin.
- Both extrinsic and intrinsic factors activate cellular senescence, a central hallmark of aging that accelerates aging in neighboring cells.
- Extrinsically induced senescent cells release factors that activate intrinsic aging, creating a connection between intrinsic and extrinsic aging.
- This connection accelerates systemic aging and contributes to the early onset of age-related disease.
- By addressing cellular senescence as the root cause of aging, longevity scientists like those on our team hope to make age-related disease a thing of the past.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging