How OS-01 BODY Pauses Biological Aging For Overall Longevity
6 min read
September 5, 2024
LONGEVITY
How OS-01 BODY Pauses Biological Aging For Overall Longevity
6 min read
September 5, 2024
LONGEVITY
A well-curated skincare regimen goes beyond mere beauty—it’s a commitment to longevity.Let’s explore the fascinating science behind biological age and discover how OneSkin's OS-01 BODY was clinically validated to pause systemic biological aging.
A well-curated skincare regimen goes beyond mere beauty—it’s a commitment to longevity.Let’s explore the fascinating science behind biological age and discover how OneSkin's OS-01 BODY was clinically validated to pause systemic biological aging.
01
Understanding Biological Age
Biological age is about more than just the years you’ve been alive; it quantifies how well your body functions. When compared to your chronological age, it can provide insight into whether your habits and environment are working for you or against you. (1, 2)
The GlycanAge Clock: A Revolutionary Approach
There are various biological, or molecular, clocks that are designed to measure the biological age of a complete body based on epigenetics and other biological signals. Since each organ has its own biological age, OneSkin has even pioneered a skin-specific molecular clock, MolClock, to predict skin’s biological age.To measure our products' effects on aging across the entire body we teamed up with GlycanAge, one of the most advanced and promising methods for measuring the biological age of the entire body.The GlycanAge Clock leverages over 30 years of scientific research and more than 200,000 tests to assess biological age comprehensively. Similar to how MolClock measures methyl groups on DNA, GlycanAge measures sugar groups on proteins, which are known to accumulate with age. (3)
01
Understanding Biological Age
Biological age is about more than just the years you’ve been alive; it quantifies how well your body functions. When compared to your chronological age, it can provide insight into whether your habits and environment are working for you or against you. (1, 2)
The GlycanAge Clock: A Revolutionary Approach
There are various biological, or molecular, clocks that are designed to measure the biological age of a complete body based on epigenetics and other biological signals. Since each organ has its own biological age, OneSkin has even pioneered a skin-specific molecular clock, MolClock, to predict skin’s biological age.To measure our products' effects on aging across the entire body we teamed up with GlycanAge, one of the most advanced and promising methods for measuring the biological age of the entire body.The GlycanAge Clock leverages over 30 years of scientific research and more than 200,000 tests to assess biological age comprehensively. Similar to how MolClock measures methyl groups on DNA, GlycanAge measures sugar groups on proteins, which are known to accumulate with age. (3)
02
The Connection Between Skin Aging and Longevity
Skin aging and overall longevity are intricately linked. As your skin ages, it reflects broader systemic changes that can impact your health. The mechanisms underlying skin aging are closely tied to cellular processes that affect your entire body. For example:
- Inflammation: Continued exposure to environmental pollutants and UV rays can trigger skin inflammation. This inflammatory response is not isolated to the skin; it can spread throughout the body, leading to systemic inflammation and accelerated aging. (4)
- Cellular Senescence: External aggressors such as UV radiation can induce cellular senescence in skin cells. These cells accumulate over time and release inflammatory cytokines, further damaging surrounding tissues and impacting overall bodily functions. (5)
02
The Connection Between Skin Aging and Longevity
Skin aging and overall longevity are intricately linked. As your skin ages, it reflects broader systemic changes that can impact your health. The mechanisms underlying skin aging are closely tied to cellular processes that affect your entire body. For example:
- Inflammation: Continued exposure to environmental pollutants and UV rays can trigger skin inflammation. This inflammatory response is not isolated to the skin; it can spread throughout the body, leading to systemic inflammation and accelerated aging. (4)
- Cellular Senescence: External aggressors such as UV radiation can induce cellular senescence in skin cells. These cells accumulate over time and release inflammatory cytokines, further damaging surrounding tissues and impacting overall bodily functions. (5)
03
OS-01 BODY: A Topical Longevity Supplement For Skin and Body
OS-01 BODY rewrites the rules of aging by tackling it at the source, ensuring your skin and health stay unstoppable.
1. OS-01 BODY Pauses Overall Biological Aging
OS-01 BODY is clinically validated to pause biological aging, measured by the GlycanAge Clock. When tested against the control group, which used a standard moisturizer for 12 weeks, participants' biological age did not change after 3 months of using OS-01 BODY but increased when using the control formula.This points to the important role that skin has on overall longevity, and OS-01’s potential to influence the aging process.
03
OS-01 BODY: A Topical Longevity Supplement For Skin and Body
OS-01 BODY rewrites the rules of aging by tackling it at the source, ensuring your skin and health stay unstoppable.
1. OS-01 BODY Pauses Overall Biological Aging
OS-01 BODY is clinically validated to pause biological aging, measured by the GlycanAge Clock. When tested against the control group, which used a standard moisturizer for 12 weeks, participants' biological age did not change after 3 months of using OS-01 BODY but increased when using the control formula.This points to the important role that skin has on overall longevity, and OS-01’s potential to influence the aging process.
2. OS-01 BODY May Reduce Systemic Inflammation
OS-01 BODY may also help reduce systemic inflammation by significantly reducing IL-8 circulating cytokines. After 12 weeks, participants using OS-01 BODY demonstrated decreasing cytokine levels and a significant decrease in IL-8 compared to the control group. This indicates that OS-01 BODY may help reduce systemic inflammation and points to the skin’s pivotal role in whole-body inflammation.Chronic inflammation is a key contributor to aging and various age-related diseases. We hypothesize that by targeting cellular senescence in the skin with the OS-01 peptide, OS-01 BODY may alleviate inflammation in the skin, reducing inflammation levels throughout the body. (6)
2. OS-01 BODY May Reduce Systemic Inflammation
OS-01 BODY may also help reduce systemic inflammation by significantly reducing IL-8 circulating cytokines. After 12 weeks, participants using OS-01 BODY demonstrated decreasing cytokine levels and a significant decrease in IL-8 compared to the control group. This indicates that OS-01 BODY may help reduce systemic inflammation and points to the skin’s pivotal role in whole-body inflammation.Chronic inflammation is a key contributor to aging and various age-related diseases. We hypothesize that by targeting cellular senescence in the skin with the OS-01 peptide, OS-01 BODY may alleviate inflammation in the skin, reducing inflammation levels throughout the body. (6)
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04
The Broader Implications: A Holistic Approach to Healthy Aging
At OneSkin, our mission is to elevate skin care to a form of health care. With our topical supplements, you’re not just investing in your skin; you’re embracing skin’s impact on your overall health and making skin care an aspect of a holistic approach to health.
04
The Broader Implications: A Holistic Approach to Healthy Aging
At OneSkin, our mission is to elevate skin care to a form of health care. With our topical supplements, you’re not just investing in your skin; you’re embracing skin’s impact on your overall health and making skin care an aspect of a holistic approach to health.
Key Takeaways:
- Choosing the right skincare is vital for beauty and enhancing long-term health.
- OneSkin’s partnership with GlycanAge to measure the effects of OS-01 BODY showed a slowdown of biological age across the entire body.
- OS-01 BODY may reduce systemic inflammation, a major contributor to aging and age-related diseases.
- OneSkin redefines skin care as a form of health care, offering a holistic approach that merges scientific innovation with practical health solutions.
Key Takeaways:
- Choosing the right skincare is vital for beauty and enhancing long-term health.
- OneSkin’s partnership with GlycanAge to measure the effects of OS-01 BODY showed a slowdown of biological age across the entire body.
- OS-01 BODY may reduce systemic inflammation, a major contributor to aging and age-related diseases.
- OneSkin redefines skin care as a form of health care, offering a holistic approach that merges scientific innovation with practical health solutions.
Disclaimers
- This article was initially published on November 2020 and has been updated.
Disclaimers
- This article was initially published on November 2020 and has been updated.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726867/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996955/
- https://pubmed.ncbi.nlm.nih.gov/24325898/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344376/
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726867/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996955/
- https://pubmed.ncbi.nlm.nih.gov/24325898/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344376/
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging