How OS-01 BODY Pauses Biological Aging For Overall Longevity
6 min read
September 5, 2024
LONGEVITY
How OS-01 BODY Pauses Biological Aging For Overall Longevity
6 min read
September 5, 2024
LONGEVITY
A well-curated skincare regimen goes beyond mere beauty—it’s a commitment to longevity.Let’s explore the fascinating science behind biological age and discover how OneSkin's OS-01 BODY was clinically validated to pause systemic biological aging.
A well-curated skincare regimen goes beyond mere beauty—it’s a commitment to longevity.Let’s explore the fascinating science behind biological age and discover how OneSkin's OS-01 BODY was clinically validated to pause systemic biological aging.
01
Understanding Biological Age
Biological age is about more than just the years you’ve been alive; it quantifies how well your body functions. When compared to your chronological age, it can provide insight into whether your habits and environment are working for you or against you. (1, 2)
The GlycanAge Clock: A Revolutionary Approach
There are various biological, or molecular, clocks that are designed to measure the biological age of a complete body based on epigenetics and other biological signals. Since each organ has its own biological age, OneSkin has even pioneered a skin-specific molecular clock, MolClock, to predict skin’s biological age.To measure our products' effects on aging across the entire body we teamed up with GlycanAge, one of the most advanced and promising methods for measuring the biological age of the entire body.The GlycanAge Clock leverages over 30 years of scientific research and more than 200,000 tests to assess biological age comprehensively. Similar to how MolClock measures methyl groups on DNA, GlycanAge measures sugar groups on proteins, which are known to accumulate with age. (3)
01
Understanding Biological Age
Biological age is about more than just the years you’ve been alive; it quantifies how well your body functions. When compared to your chronological age, it can provide insight into whether your habits and environment are working for you or against you. (1, 2)
The GlycanAge Clock: A Revolutionary Approach
There are various biological, or molecular, clocks that are designed to measure the biological age of a complete body based on epigenetics and other biological signals. Since each organ has its own biological age, OneSkin has even pioneered a skin-specific molecular clock, MolClock, to predict skin’s biological age.To measure our products' effects on aging across the entire body we teamed up with GlycanAge, one of the most advanced and promising methods for measuring the biological age of the entire body.The GlycanAge Clock leverages over 30 years of scientific research and more than 200,000 tests to assess biological age comprehensively. Similar to how MolClock measures methyl groups on DNA, GlycanAge measures sugar groups on proteins, which are known to accumulate with age. (3)
02
The Connection Between Skin Aging and Longevity
Skin aging and overall longevity are intricately linked. As your skin ages, it reflects broader systemic changes that can impact your health. The mechanisms underlying skin aging are closely tied to cellular processes that affect your entire body. For example:
- Inflammation: Continued exposure to environmental pollutants and UV rays can trigger skin inflammation. This inflammatory response is not isolated to the skin; it can spread throughout the body, leading to systemic inflammation and accelerated aging. (4)
- Cellular Senescence: External aggressors such as UV radiation can induce cellular senescence in skin cells. These cells accumulate over time and release inflammatory cytokines, further damaging surrounding tissues and impacting overall bodily functions. (5)
02
The Connection Between Skin Aging and Longevity
Skin aging and overall longevity are intricately linked. As your skin ages, it reflects broader systemic changes that can impact your health. The mechanisms underlying skin aging are closely tied to cellular processes that affect your entire body. For example:
- Inflammation: Continued exposure to environmental pollutants and UV rays can trigger skin inflammation. This inflammatory response is not isolated to the skin; it can spread throughout the body, leading to systemic inflammation and accelerated aging. (4)
- Cellular Senescence: External aggressors such as UV radiation can induce cellular senescence in skin cells. These cells accumulate over time and release inflammatory cytokines, further damaging surrounding tissues and impacting overall bodily functions. (5)
03
OS-01 BODY: A Topical Longevity Supplement For Skin and Body
OS-01 BODY rewrites the rules of aging by tackling it at the source, ensuring your skin and health stay unstoppable.
1. OS-01 BODY Pauses Overall Biological Aging
OS-01 BODY is clinically validated to pause biological aging, measured by the GlycanAge Clock. When tested against the control group, which used a standard moisturizer for 12 weeks, participants' biological age did not change after 3 months of using OS-01 BODY but increased when using the control formula.This points to the important role that skin has on overall longevity, and OS-01’s potential to influence the aging process.
03
OS-01 BODY: A Topical Longevity Supplement For Skin and Body
OS-01 BODY rewrites the rules of aging by tackling it at the source, ensuring your skin and health stay unstoppable.
1. OS-01 BODY Pauses Overall Biological Aging
OS-01 BODY is clinically validated to pause biological aging, measured by the GlycanAge Clock. When tested against the control group, which used a standard moisturizer for 12 weeks, participants' biological age did not change after 3 months of using OS-01 BODY but increased when using the control formula.This points to the important role that skin has on overall longevity, and OS-01’s potential to influence the aging process.
2. OS-01 BODY May Reduce Systemic Inflammation
OS-01 BODY may also help reduce systemic inflammation by significantly reducing IL-8 circulating cytokines. After 12 weeks, participants using OS-01 BODY demonstrated decreasing cytokine levels and a significant decrease in IL-8 compared to the control group. This indicates that OS-01 BODY may help reduce systemic inflammation and points to the skin’s pivotal role in whole-body inflammation.Chronic inflammation is a key contributor to aging and various age-related diseases. We hypothesize that by targeting cellular senescence in the skin with the OS-01 peptide, OS-01 BODY may alleviate inflammation in the skin, reducing inflammation levels throughout the body. (6)
2. OS-01 BODY May Reduce Systemic Inflammation
OS-01 BODY may also help reduce systemic inflammation by significantly reducing IL-8 circulating cytokines. After 12 weeks, participants using OS-01 BODY demonstrated decreasing cytokine levels and a significant decrease in IL-8 compared to the control group. This indicates that OS-01 BODY may help reduce systemic inflammation and points to the skin’s pivotal role in whole-body inflammation.Chronic inflammation is a key contributor to aging and various age-related diseases. We hypothesize that by targeting cellular senescence in the skin with the OS-01 peptide, OS-01 BODY may alleviate inflammation in the skin, reducing inflammation levels throughout the body. (6)
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04
The Broader Implications: A Holistic Approach to Healthy Aging
At OneSkin, our mission is to elevate skin care to a form of health care. With our topical supplements, you’re not just investing in your skin; you’re embracing skin’s impact on your overall health and making skin care an aspect of a holistic approach to health.
04
The Broader Implications: A Holistic Approach to Healthy Aging
At OneSkin, our mission is to elevate skin care to a form of health care. With our topical supplements, you’re not just investing in your skin; you’re embracing skin’s impact on your overall health and making skin care an aspect of a holistic approach to health.
Key Takeaways:
- Choosing the right skincare is vital for beauty and enhancing long-term health.
- OneSkin’s partnership with GlycanAge to measure the effects of OS-01 BODY showed a slowdown of biological age across the entire body.
- OS-01 BODY may reduce systemic inflammation, a major contributor to aging and age-related diseases.
- OneSkin redefines skin care as a form of health care, offering a holistic approach that merges scientific innovation with practical health solutions.
Key Takeaways:
- Choosing the right skincare is vital for beauty and enhancing long-term health.
- OneSkin’s partnership with GlycanAge to measure the effects of OS-01 BODY showed a slowdown of biological age across the entire body.
- OS-01 BODY may reduce systemic inflammation, a major contributor to aging and age-related diseases.
- OneSkin redefines skin care as a form of health care, offering a holistic approach that merges scientific innovation with practical health solutions.
Disclaimers
- This article was initially published on November 2020 and has been updated.
Disclaimers
- This article was initially published on November 2020 and has been updated.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726867/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996955/
- https://pubmed.ncbi.nlm.nih.gov/24325898/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344376/
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726867/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996955/
- https://pubmed.ncbi.nlm.nih.gov/24325898/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344376/
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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