How chronic stress makes you age faster

3 min read

April 12,2022
LONGEVITY

How chronic stress makes you age faster

3 min read

April 12,2022
LONGEVITY
From work pressures to unexpected visits from the in-laws, daily stress is a reality of life. With a healthy lifestyle, most of us bounce back from intermittent stress and return to a balanced state. But for some of us, relief never comes. Chronic stress, defined as a persistent sense of feeling pressured and overwhelmed over a long period of time, takes an incredible toll on our bodies. [1] In fact, studies have shown that chronic stress increases multiple hallmarks of aging, speeds the rate at which we age, and increases our risk for numerous age-related diseases. Join us as we dig into the science and explore the compelling reasons why managing stress might be one of the most important things you can do for your longevity.
From work pressures to unexpected visits from the in-laws, daily stress is a reality of life. With a healthy lifestyle, most of us bounce back from intermittent stress and return to a balanced state. But for some of us, relief never comes. Chronic stress, defined as a persistent sense of feeling pressured and overwhelmed over a long period of time, takes an incredible toll on our bodies. [1] In fact, studies have shown that chronic stress increases multiple hallmarks of aging, speeds the rate at which we age, and increases our risk for numerous age-related diseases. Join us as we dig into the science and explore the compelling reasons why managing stress might be one of the most important things you can do for your longevity.
01

Chronic stress induces cellular senescence

A chronic state of mental stress is a risk factor for numerous diseases. To understand why, scientists have examined the underlying similarities between these diseases. A common feature seems to be cellular senescence, the accumulation of dead “zombie” cells that secrete harmful biochemical signals–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. [2]With cellular senescence as a common link between stress-related diseases, scientists took a closer look to determine whether chronic stress itself functionally increases rates of cellular senescence. In a study, researchers asked 73 adults to self-report their stress levels. Each participant also donated a blood sample that scientists used to measure P16ᴵᴺᴷ⁴ᵃ, a key marker of cellular senescence. Individuals with greater chronic stress exposure showed higher levels of P16ᴵᴺᴷ⁴ᵃ, indicating higher overall levels of cellular senescence. [3]Cellular senescence is associated with cancer, cardiovascular, neurodegenerative and autoimmune disorders. While many of these diseases are age-related, there is some evidence showing that persistent, severe stress can trigger them earlier in a person’s life. This may be due in part to a phenomenon called immunosenescence, senescence in immune cells. When increasing numbers of immune cells become senescent, the body experiences a deterioration in immune response not normally seen in younger people. This can lead to the development and acceleration of two additional aging hallmarks: telomere attrition and chronic inflammation. [2]
01

Chronic stress induces cellular senescence

A chronic state of mental stress is a risk factor for numerous diseases. To understand why, scientists have examined the underlying similarities between these diseases. A common feature seems to be cellular senescence, the accumulation of dead “zombie” cells that secrete harmful biochemical signals–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. [2]With cellular senescence as a common link between stress-related diseases, scientists took a closer look to determine whether chronic stress itself functionally increases rates of cellular senescence. In a study, researchers asked 73 adults to self-report their stress levels. Each participant also donated a blood sample that scientists used to measure P16ᴵᴺᴷ⁴ᵃ, a key marker of cellular senescence. Individuals with greater chronic stress exposure showed higher levels of P16ᴵᴺᴷ⁴ᵃ, indicating higher overall levels of cellular senescence. [3]Cellular senescence is associated with cancer, cardiovascular, neurodegenerative and autoimmune disorders. While many of these diseases are age-related, there is some evidence showing that persistent, severe stress can trigger them earlier in a person’s life. This may be due in part to a phenomenon called immunosenescence, senescence in immune cells. When increasing numbers of immune cells become senescent, the body experiences a deterioration in immune response not normally seen in younger people. This can lead to the development and acceleration of two additional aging hallmarks: telomere attrition and chronic inflammation. [2]
02

Chronic stress increases inflammaging

Like stress, inflammation is a normal part of the human experience. It’s the body’s main way of identifying harm–whether from pathogens or injury–and initiating the healing process. Acute, or short-term inflammation, is essential to our health. But when that same inflammation becomes constant, it can actually do more harm than good. [4]Age-associated chronic inflammation, also known as inflammaging, is associated with alterations in the body’s immune response. It’s now understood that these alterations occur when the body’s immune response is disrupted due to immunosenescence. This continuous, systemic inflammation can contribute to the development of several diseases including atherosclerosis, diabetes, and hypertension.In addition to its link with stress-induced cellular senescence, inflammaging is also believed to be directly tied to chronic psychological stress by altering levels of cytokines, small proteins that are important in cellular signaling. During the aging process, the body experiences a decrease in anti-inflammatory cytokines, and a simultaneous increase in pro-inflammatory cytokines, leading to overall higher levels of inflammation. Scientists now believe that chronic psychological stress further stimulates pro-inflammatory cytokines. In fact, some studies have shown that antidepressants, which are used to reduce psychological stress, actually reduce enhanced levels of these pro-inflammatory cytokines. [2]This data indicates that living in a constant state of psychological stress can actually accelerate the inflammaging that you might normally experience as a result of the aging process–hastening the cellular damage caused by inflammation so that you actually age more quickly.
02

Chronic stress increases inflammaging

Like stress, inflammation is a normal part of the human experience. It’s the body’s main way of identifying harm–whether from pathogens or injury–and initiating the healing process. Acute, or short-term inflammation, is essential to our health. But when that same inflammation becomes constant, it can actually do more harm than good. [4]Age-associated chronic inflammation, also known as inflammaging, is associated with alterations in the body’s immune response. It’s now understood that these alterations occur when the body’s immune response is disrupted due to immunosenescence. This continuous, systemic inflammation can contribute to the development of several diseases including atherosclerosis, diabetes, and hypertension.In addition to its link with stress-induced cellular senescence, inflammaging is also believed to be directly tied to chronic psychological stress by altering levels of cytokines, small proteins that are important in cellular signaling. During the aging process, the body experiences a decrease in anti-inflammatory cytokines, and a simultaneous increase in pro-inflammatory cytokines, leading to overall higher levels of inflammation. Scientists now believe that chronic psychological stress further stimulates pro-inflammatory cytokines. In fact, some studies have shown that antidepressants, which are used to reduce psychological stress, actually reduce enhanced levels of these pro-inflammatory cytokines. [2]This data indicates that living in a constant state of psychological stress can actually accelerate the inflammaging that you might normally experience as a result of the aging process–hastening the cellular damage caused by inflammation so that you actually age more quickly.
03

Chronic stress induces telomere attrition

In addition to its effects on cellular senescence and inflammation, research shows that chronic stress can have a structural impact on our chromosomes, tightly packed molecules that house our DNA.Telomeres are protective casings located at the end of each chromosome that shield our chromosomes from becoming frayed or tangled. Because our telomeres shorten every time a cell divides, our telomere length naturally shortens with age. [5] Once telomeres become too short, cells experience senescence, cell death, or oncogenic transformations where they can become cancerous. Shorter telomeres have been associated with increased risk for diseases and overall shorter lifespan. [6]When we’re young and healthy, telomere attrition is kept at bay with telomerase, an enzyme that replenishes telomere length even as our cells continue to divide. However, chronic stress–and constantly high levels of the stress hormone cortisol–decreases the body’s natural supply of telomerase. This means that chronic stress can actually speed the rate at which we experience telomere attrition, accelerating its systemic aging effects. [7]
03

Chronic stress induces telomere attrition

In addition to its effects on cellular senescence and inflammation, research shows that chronic stress can have a structural impact on our chromosomes, tightly packed molecules that house our DNA.Telomeres are protective casings located at the end of each chromosome that shield our chromosomes from becoming frayed or tangled. Because our telomeres shorten every time a cell divides, our telomere length naturally shortens with age. [5] Once telomeres become too short, cells experience senescence, cell death, or oncogenic transformations where they can become cancerous. Shorter telomeres have been associated with increased risk for diseases and overall shorter lifespan. [6]When we’re young and healthy, telomere attrition is kept at bay with telomerase, an enzyme that replenishes telomere length even as our cells continue to divide. However, chronic stress–and constantly high levels of the stress hormone cortisol–decreases the body’s natural supply of telomerase. This means that chronic stress can actually speed the rate at which we experience telomere attrition, accelerating its systemic aging effects. [7]
04

Chronic stress increases oxidative stress

You know you should be eating a lot of antioxidant-rich fruits and veggies, but do you know why? It’s because antioxidants naturally combat reactive oxygen species (ROS), unstable molecules also known as free radicals that can damage our cells, alter cellular metabolism, and increase inflammation.From the time we are born, our cells are constantly managing ROS. But our ability to neutralize ROS can wane as we age, leading to oxidative stress–a phenomenon associated with physical signs of aging. Interestingly, within the body, the main source of ROS is actually our own mitochondria, which become dysfunctional as a result of inflammaging. [2]Our ability to fend off oxidative stress becomes further impaired when we experience a constant state of psychological stress. In a study, scientists compared patients with PTSD to control individuals and discovered that people with PTSD show signs of reduced ROS metabolism. This means that they experience higher rates of oxidative stress. Because oxidative stress itself seems to trigger crosstalk between the immune and central neural systems, scientists believe that stress-induced oxidative stress may actually create a pernicious cycle that further degrades emotional wellbeing, leading to more psychological stress. [2]
04

Chronic stress increases oxidative stress

You know you should be eating a lot of antioxidant-rich fruits and veggies, but do you know why? It’s because antioxidants naturally combat reactive oxygen species (ROS), unstable molecules also known as free radicals that can damage our cells, alter cellular metabolism, and increase inflammation.From the time we are born, our cells are constantly managing ROS. But our ability to neutralize ROS can wane as we age, leading to oxidative stress–a phenomenon associated with physical signs of aging. Interestingly, within the body, the main source of ROS is actually our own mitochondria, which become dysfunctional as a result of inflammaging. [2]Our ability to fend off oxidative stress becomes further impaired when we experience a constant state of psychological stress. In a study, scientists compared patients with PTSD to control individuals and discovered that people with PTSD show signs of reduced ROS metabolism. This means that they experience higher rates of oxidative stress. Because oxidative stress itself seems to trigger crosstalk between the immune and central neural systems, scientists believe that stress-induced oxidative stress may actually create a pernicious cycle that further degrades emotional wellbeing, leading to more psychological stress. [2]
05

Putting it all together

Once you dig into the science, it’s easy to see that everything is connected. Increased cellular senescence, inflammaging, telomere attrition, and oxidative stress are all magnified by one another. In short, chronic stress kicks off a cascade of accelerated aging factors that amplify one another, creating system-wide impacts. This underlines the incredibly damaging potential of living a life with unregulated stress levels.So how can you help manage chronic stress? In addition to seeking out mental health help from a therapist, experts recommend getting regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness. While these tactics may seem mundane in the face of major psychological stress, small daily lifestyle shifts can help the body recover both mentally and physically from a state of chronic stress. [1]
05

Putting it all together

Once you dig into the science, it’s easy to see that everything is connected. Increased cellular senescence, inflammaging, telomere attrition, and oxidative stress are all magnified by one another. In short, chronic stress kicks off a cascade of accelerated aging factors that amplify one another, creating system-wide impacts. This underlines the incredibly damaging potential of living a life with unregulated stress levels.So how can you help manage chronic stress? In addition to seeking out mental health help from a therapist, experts recommend getting regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness. While these tactics may seem mundane in the face of major psychological stress, small daily lifestyle shifts can help the body recover both mentally and physically from a state of chronic stress. [1]
Key Takeaways:
  • Studies have shown that chronic stress speeds the rate at which we age, and increases our risk for numerous age-related diseases.
  • Individuals with chronic stress show higher markers of cellular senescence, a central hallmark of aging tied to cancer, cardiovascular, neurodegenerative and autoimmune disorders.
  • Chronic psychological stress also stimulates pro-inflammatory cytokines and systemic inflammation, a factor linked to several diseases including atherosclerosis, diabetes, and hypertension.
  • Constant exposure to the stress hormone, cortisol, decreases the body’s natural supply of telomerase, an enzyme that prevents telomere attrition, a hallmark of aging linked to diminished lifespan.
  • Higher rates of psychological stress are linked to increased oxidative stress, the overproduction of free radicals that damage our cells and induce inflammation.
  • Regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness can help mitigate the psychological and physical impacts of chronic stress.
Key Takeaways:
  • Studies have shown that chronic stress speeds the rate at which we age, and increases our risk for numerous age-related diseases.
  • Individuals with chronic stress show higher markers of cellular senescence, a central hallmark of aging tied to cancer, cardiovascular, neurodegenerative and autoimmune disorders.
  • Chronic psychological stress also stimulates pro-inflammatory cytokines and systemic inflammation, a factor linked to several diseases including atherosclerosis, diabetes, and hypertension.
  • Constant exposure to the stress hormone, cortisol, decreases the body’s natural supply of telomerase, an enzyme that prevents telomere attrition, a hallmark of aging linked to diminished lifespan.
  • Higher rates of psychological stress are linked to increased oxidative stress, the overproduction of free radicals that damage our cells and induce inflammation.
  • Regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness can help mitigate the psychological and physical impacts of chronic stress.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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Skin Care is Health Care: Why Skin Care is the Key...
Full OneSkin Regimen
How Do Our Products Work Together?
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The Connection Between Mental Health, Age Percepti...
OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
MolClock: Using Epigenetics to Measure The Biologi...
How OS-01 BODY Pauses Biological Aging For Overall...
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Biohacking Healthy Aging: The Organs of Longevity
Does Niacinamide Help With Acne & Scarring?
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6 Common In-Office Skin Treatments to Complement y...
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Exploring Alternatives to Botox
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Recognizing Signs of Over-Exfoliated Skin
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OS-01 BODY SPF and OS-01 BODY: Even Better Togethe...
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Non-Comedogenic vs Comedogenic Skin Care Products
Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
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How Much Sunscreen to Apply
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Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
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Addressing the Need for Indoor Sun Protection
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The Science of Sunburns: How to Treat and Prevent ...
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Pollution
Can Air Quality Affect Skin? Exploring the Impact ...
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Understanding the Relationship Between Sleep and U...
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Exploring the Effects of Quality Sleep on Your Ski...
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How to Improve Gut Microbiome
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Exploring Caloric Restriction and Its Effects on A...
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What’s the Connection Between Quality Sleep and Lo...
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Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
The Microbiome Diet and Its Effects on Skin
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Cold Exposure: Hype or Longevity Boosting?
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Eat Better, Live Longer: Top Foods for Longevity
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How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
OS-01 BODY
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What Causes Dark Circles Under and Around Your Eyes?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
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Lip Balm Ingredients: What to Look for and What to...
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Exploring Blue Zones: How Can We Optimize Our Heal...
Lips
Nurturing Your Lips: How to Keep Them Moisturized ...
Lips
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How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
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Lip Sunscreen: Do Lips Need SPF Protection?
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The Science of Gratitude
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Removing Sunscreen: Tips for Clean and Healthy Ski...
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Skin Explained: Is Skin An Organ?
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UV Light and Skin: Effects and Protection Strategi...
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Diving into Dermis: Functions and Significance
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Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
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Hypodermis: Exploring Its Vital Functions
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The EU is Limiting Retinol in Skincare: Here’s Eve...
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Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
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How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
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The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles
How to Address Stomach Wrinkles For Smoother Skin
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A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling
What is Skin Cycling? Understanding, Embracing, an...
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Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
What is Tinted Sunscreen?
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2 Types of Wrinkles and Tips for Treating Them
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A Comprehensive Guide to Understanding the Differe...
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An In-Depth Look at Glycerin: What is it and What ...
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Exploring the Benefits of Glycerin for Skin Health
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Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
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Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
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Dry Skin 101: How To Identify This Skin Type
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Developing a Skin Care Routine for Normal Skin: 4 ...
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Understanding Oily Skin: Causes & Characteristics
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7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
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Perfect Skin Care Routine for Combination Skin
4 Steps to Crafting the Perfect Skin Care Routine ...
Managing Combination Skin
A Comprehensive Guide to Understanding and Managin...
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An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
Restoring Dry Skin Around The Eyes
101 Guide To Restoring Dry Skin Around The Eyes
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How to Remove Lingering Dead Skin Cells On the Fac...
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Hallmarks Of Aging - One Skin Technologies
Hallmarks of Aging
What Is Sensitive Skin
What is Sensitive Skin?
How OS-01 Works on Mature Skin
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
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Eye Skin Ages Faster: Here’s How OS-01 Can Help
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Why We Want Skin To Be More, Not Less
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Yes, You Need Sunscreen During Winter
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What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
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What is the Best Skin Care Regimen for Aging Skin
What is the Best Skin Care Regimen for Aging Skin?
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7 Benefits of Jojoba Oil
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What are the Benefits of Sulforaphane?
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A Simplified Guide To The Different Skin Texture T...
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What Foods Cause Acne and Which Fight Against It?
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What Is Exfoliation & Is It A Necessary Measure Fo...
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OS-

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The Top 3 Benefits of Peptides for Skin
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Peptides vs Retinol: Is One Better For Increasing ...
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Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
Three Ways To Extend Your Skinspan Starting With Y...
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What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Longevity
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
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Cell Turnover & Why It Slows As We Age
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101 Guide To Skin Tightening
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How to Reduce Skin Inflammation & Redness
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Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barrier
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care and Longevity
Representation of the Black Community in Skin Care...
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Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
What Is Senescence & Its Relationship To Aging?
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Biological Age: What is Biological Age, Why Does i...
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What is a peptide?
Peptides: the first piece of th...
Health Is The New Wealth - One Skin Technologies
Health Is The New Wealth
Sleep: Nature’s Restart Button? - One Skin Technologies
The Correlation Between Sleep and Skin: Why It Mat...
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Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging - One Skin Technologies
Healthspan: A New Way To Think About Aging