How OneSkin Developed the OS-01 Peptide
Our Goal: To develop Products Capable of Slowing & Reversing Skin Aging
6 min read
THE ONESKIN TEAM
April 13,2022
LIFE STYLE
How OneSkin Developed the OS-01 Peptide
Our Goal: To develop Products Capable of Slowing & Reversing Skin Aging
6 min read
THE ONESKIN TEAM
April 13,2022
LIFE STYLE
With thousands of skin care products claiming to reduce the signs of aging, it's oftentimes challenging to distinguish between validated science-based results and clever marketing. Unfortunately, most products in the anti-aging industry fall into the latter category, with little evidence to support their effects on skin aging. OneSkin is changing that.Here at OneSkin, we dive deep into the science of how and why our skin ages, validating new and existing “anti-aging” molecules against our cutting-edge R&D platform not only for their rejuvenation effects, but for their effects on long-term skin health. That is how we developed a line of science-driven Topical Supplements aimed at extending the longevity of skin.What’s the secret to our highly effective line of Topical Supplements? They are powered by the first molecule proven to reverse the biological age of skin: a novel peptide, called OS-01. [1,2]So what is OS-01, and how did we develop it?
With thousands of skin care products claiming to reduce the signs of aging, it's oftentimes challenging to distinguish between validated science-based results and clever marketing. Unfortunately, most products in the anti-aging industry fall into the latter category, with little evidence to support their effects on skin aging. OneSkin is changing that.Here at OneSkin, we dive deep into the science of how and why our skin ages, validating new and existing “anti-aging” molecules against our cutting-edge R&D platform not only for their rejuvenation effects, but for their effects on long-term skin health. That is how we developed a line of science-driven Topical Supplements aimed at extending the longevity of skin.What’s the secret to our highly effective line of Topical Supplements? They are powered by the first molecule proven to reverse the biological age of skin: a novel peptide, called OS-01. [1,2]So what is OS-01, and how did we develop it?
01
Our Target: Cellular Senescence
To understand why OS-01 is so effective against skin aging, we must first understand the process of aging that the OS-01 peptide disrupts: cellular senescence.One of the 12 hallmarks of aging, cellular senescence is a biological process in which a cell permanently halts replication and proliferation. To keep a long story short, senescent cells release inflammatory factors that accelerate aging, and they also emit signals that force neighboring cells into senescence.As we age, our body becomes less effective at eliminating senescent cells from our bodies, causing them to build up and linger in our tissues, subsequently accelerating the biological aging process. In skin, this increased senescent burden leads to a weakened skin barrier and deterioration of skin health, which accelerates the development of visible symptoms of aging, such as fine lines, sagging, and thinning.So how do you prevent senescent cells from accumulating in tissues? There exists a revolutionary class of molecules called “senotherapeutics” that are able to reduce the build up of senescent cells in tissues, serving as an effective strategy to slow and even reverse aging. Human application of senotherapeutic molecules has the potential to prevent the onset of age-related diseases and extend human healthspan.Given senotherapeutic’s promising potential, our founding team of longevity scientists set out to develop such a molecule capable of reducing the accumulation of senescent cells, specifically in skin tissue.
01
Our Target: Cellular Senescence
To understand why OS-01 is so effective against skin aging, we must first understand the process of aging that the OS-01 peptide disrupts: cellular senescence.One of the 12 hallmarks of aging, cellular senescence is a biological process in which a cell permanently halts replication and proliferation. To keep a long story short, senescent cells release inflammatory factors that accelerate aging, and they also emit signals that force neighboring cells into senescence.As we age, our body becomes less effective at eliminating senescent cells from our bodies, causing them to build up and linger in our tissues, subsequently accelerating the biological aging process. In skin, this increased senescent burden leads to a weakened skin barrier and deterioration of skin health, which accelerates the development of visible symptoms of aging, such as fine lines, sagging, and thinning.So how do you prevent senescent cells from accumulating in tissues? There exists a revolutionary class of molecules called “senotherapeutics” that are able to reduce the build up of senescent cells in tissues, serving as an effective strategy to slow and even reverse aging. Human application of senotherapeutic molecules has the potential to prevent the onset of age-related diseases and extend human healthspan.Given senotherapeutic’s promising potential, our founding team of longevity scientists set out to develop such a molecule capable of reducing the accumulation of senescent cells, specifically in skin tissue.
02
How the OS-01 Peptide was Developed
Starting in 2016, our founding team of female PhDs underwent a rigorous R&D process to develop a senotherapeutic peptide effective at reducing cellular senescence in skin and improving skin's overall health.To begin this process, OneSkin’s R&D team used computational algorithms to identify a library of over 800 novel peptides predicted to have substantial senotherapeutic properties. Each peptide was then evaluated for its effectiveness at reducing the amount of senescent cells in ex vivo human skin models and samples, effectively quantifying the peptides’ senotherapeutic capabilities.From this process, our scientific team identified 2 peptides (OS-01 and OS-02) with an unprecedented ability to reduce cellular senescence in skin. After further testing against our cutting-edge R&D platform to evaluate each peptide’s full potential for improving skin health and rejuvenating skin, OS-01 proved the most effective. After further optimizations, OS-01 was superior at reducing the biological age of skin (measured by MolClock) and improving other skin health markers, such as epidermal thickness, cellular repair markers, and collagen production. [1,2]OS-01 is now our proprietary peptide, which we deliver to you through our line of OS-01 Topical Supplements and SPFs.
02
How the OS-01 Peptide was Developed
Starting in 2016, our founding team of female PhDs underwent a rigorous R&D process to develop a senotherapeutic peptide effective at reducing cellular senescence in skin and improving skin's overall health.To begin this process, OneSkin’s R&D team used computational algorithms to identify a library of over 800 novel peptides predicted to have substantial senotherapeutic properties. Each peptide was then evaluated for its effectiveness at reducing the amount of senescent cells in ex vivo human skin models and samples, effectively quantifying the peptides’ senotherapeutic capabilities.From this process, our scientific team identified 2 peptides (OS-01 and OS-02) with an unprecedented ability to reduce cellular senescence in skin. After further testing against our cutting-edge R&D platform to evaluate each peptide’s full potential for improving skin health and rejuvenating skin, OS-01 proved the most effective. After further optimizations, OS-01 was superior at reducing the biological age of skin (measured by MolClock) and improving other skin health markers, such as epidermal thickness, cellular repair markers, and collagen production. [1,2]OS-01 is now our proprietary peptide, which we deliver to you through our line of OS-01 Topical Supplements and SPFs.
03
How Effective is the OS-01 Peptide at Targeting Cellular Senescence?
Measuring the effectiveness of molecules at reducing cellular senescence can be relatively simple. By staining skin models with a chemical that selectively colors senescent cells blue (beta galactosidase), we can count the number of senescent cells (blue) underneath the microscope before and after exposure to molecules of interest.Using this technique, we found that the OS-01 peptide reduced the number of senescent cells in human skin models by up to 50%, [1,2] making the OS-01 peptide the most effective senotherapeutic compound tested from our library of over 800 promising peptides.
03
How Effective is the OS-01 Peptide at Targeting Cellular Senescence?
Measuring the effectiveness of molecules at reducing cellular senescence can be relatively simple. By staining skin models with a chemical that selectively colors senescent cells blue (beta galactosidase), we can count the number of senescent cells (blue) underneath the microscope before and after exposure to molecules of interest.Using this technique, we found that the OS-01 peptide reduced the number of senescent cells in human skin models by up to 50%, [1,2] making the OS-01 peptide the most effective senotherapeutic compound tested from our library of over 800 promising peptides.
By staining ex vivo human skin with beta galactosidase, OneSkin scientists were able to measure the number of senescent cells before and after exposure to the OS-01 peptide. The OS-01 peptide reduced the number of senescent cells in human skin models by up to 50%. (Zonari, A., et al. npj Aging, 2023)
By staining ex vivo human skin with beta galactosidase, OneSkin scientists were able to measure the number of senescent cells before and after exposure to the OS-01 peptide. The OS-01 peptide reduced the number of senescent cells in human skin models by up to 50%. (Zonari, A., et al. npj Aging, 2023)
04
What Does This Mean for Skin Aging?
Our team of scientists was also able to measure the biological age of skin before and after exposure to the OS-01 peptide using MolClock–a computational algorithm that can predict skin’s biological age based on its genetic material.
04
What Does This Mean for Skin Aging?
Our team of scientists was also able to measure the biological age of skin before and after exposure to the OS-01 peptide using MolClock–a computational algorithm that can predict skin’s biological age based on its genetic material.
Measured in lab studies on human skin samples using MolClock, OneSkin’s proprietary algorithm that predicts skin’s biological age. Skin treated with the OS-01 peptide displayed a significant decrease in skin’s biological age compared to skin with no treatment after 5 days. (Zonari, A., et al. npj Aging, 2023) (Boroni, M. et al. Clinical Epigenetics, 2020) Note: In npj Aging publication,"Pep 14" = OS-01 peptide
Measured in lab studies on human skin samples using MolClock, OneSkin’s proprietary algorithm that predicts skin’s biological age. Skin treated with the OS-01 peptide displayed a significant decrease in skin’s biological age compared to skin with no treatment after 5 days. (Zonari, A., et al. npj Aging, 2023) (Boroni, M. et al. Clinical Epigenetics, 2020) Note: In npj Aging publication,"Pep 14" = OS-01 peptide
Astoundingly, after only 5 days of exposure to the OS-01 peptide, the skin’s biological age was reduced by 2.6 years*, making the OS-01 peptide the first molecule scientifically proven to reduce skin’s biological age! [1,2]These results confirm that topically applying our novel senotherapeutic compound, the OS-01 peptide, to skin is indeed an effective way to reduce the senescent burden in skin tissue, slowing the skin aging process, and subsequently reducing the biological age of skin.*Note, these results were found in the lab, not in human studies.
Astoundingly, after only 5 days of exposure to the OS-01 peptide, the skin’s biological age was reduced by 2.6 years*, making the OS-01 peptide the first molecule scientifically proven to reduce skin’s biological age! [1,2]These results confirm that topically applying our novel senotherapeutic compound, the OS-01 peptide, to skin is indeed an effective way to reduce the senescent burden in skin tissue, slowing the skin aging process, and subsequently reducing the biological age of skin.*Note, these results were found in the lab, not in human studies.
Key Takeaways:
- Senescent (aged) cells accumulate in the skin, accelerating the aging process and leading to a deterioration of skin health which contributes to visible signs of aging, such as fine lines and skin sagging.
- Oneskin is the first company specifically targeting cellular senescence as a skin rejuvenation approach.
- By screening a library of over 800 peptides against our cutting-edge R&D platform, OneSkin developed the OS-01 peptide, which was superior in reducing senescent cells in skin and improving skin health markers.
- The OS-01 peptide is the first molecule scientifically proven to reduce skin’s biological age by reducing senescent burden in skin. [1,2]
Key Takeaways:
- Senescent (aged) cells accumulate in the skin, accelerating the aging process and leading to a deterioration of skin health which contributes to visible signs of aging, such as fine lines and skin sagging.
- Oneskin is the first company specifically targeting cellular senescence as a skin rejuvenation approach.
- By screening a library of over 800 peptides against our cutting-edge R&D platform, OneSkin developed the OS-01 peptide, which was superior in reducing senescent cells in skin and improving skin health markers.
- The OS-01 peptide is the first molecule scientifically proven to reduce skin’s biological age by reducing senescent burden in skin. [1,2]
References
- Based on data from lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
References
- Based on data from lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
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Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging