Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01?
3 min read
JUNE 2, 2023
June 02,2023
SKIN SCIENCE
Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01?
3 min read
JUNE 2, 2023
June 02,2023
SKIN SCIENCE
The impacts of aging are so much more than skin-deep. With time, our bodies become more vulnerable to age-related diseases like heart disease, Alzheimer’s and cancer: leading causes of mortality that cause incalculable suffering and take an enormous toll on our families, our healthcare system, and our society. Reducing this suffering is the reason why longevity researchers do what they do – study the science of aging to uncover new therapies that can help people live longer lives in good health.At the forefront of this research is the development of senotherapeutics, molecules capable of reducing cellular senescence, a central hallmark of aging. As we age, senescent cells begin to accumulate in our bodies. These dead, zombie-like cells have ceased to divide but remain metabolically active, releasing pro-inflammatory chemical signals called senescence-associated secretory phenotypes (SASP) that induce neighboring cells into senescence. Associated with both intrinsic and extrinsic aging, senescence has been linked to the development of a number of age-related diseases. [1]By targeting senescent cells, senotherapeutics like our OS-01 peptide may have the potential to delay, prevent, or treat age-related diseases. As longevity research progresses, scientists have discovered that not all senotherapeutics work in the same way. In fact, there are two major types of senotherapeutics–senolytics and senomorphics. So what separates these two types of molecules and how they function? Let’s dive deeper into the fascinating world of senotherapeutics – and how our scientists evaluated OS-01 to discover its type.
The impacts of aging are so much more than skin-deep. With time, our bodies become more vulnerable to age-related diseases like heart disease, Alzheimer’s and cancer: leading causes of mortality that cause incalculable suffering and take an enormous toll on our families, our healthcare system, and our society. Reducing this suffering is the reason why longevity researchers do what they do – study the science of aging to uncover new therapies that can help people live longer lives in good health.At the forefront of this research is the development of senotherapeutics, molecules capable of reducing cellular senescence, a central hallmark of aging. As we age, senescent cells begin to accumulate in our bodies. These dead, zombie-like cells have ceased to divide but remain metabolically active, releasing pro-inflammatory chemical signals called senescence-associated secretory phenotypes (SASP) that induce neighboring cells into senescence. Associated with both intrinsic and extrinsic aging, senescence has been linked to the development of a number of age-related diseases. [1]By targeting senescent cells, senotherapeutics like our OS-01 peptide may have the potential to delay, prevent, or treat age-related diseases. As longevity research progresses, scientists have discovered that not all senotherapeutics work in the same way. In fact, there are two major types of senotherapeutics–senolytics and senomorphics. So what separates these two types of molecules and how they function? Let’s dive deeper into the fascinating world of senotherapeutics – and how our scientists evaluated OS-01 to discover its type.
01
What is the difference between a senolytic and a senomorphic?
While both senolytics and senomorphics reduce cellular senescence, they do so in different ways. Senolytics eliminate senescent cells, while senomorphics prevent them from spreading by inhibiting the release of SASP. [2] While the difference might seem nuanced, the two can actually have very different effects. By selectively killing senescent cells, senolytics reduce the overall cell count. Senomorphics, on the other hand, maintain the overall number of cells while reducing the number of senescent cells.Both senolytics and senomorphics have potential benefits and drawbacks, and their effectiveness and safety depend on the specific drug, the disease being targeted, and the patient population.
01
What is the difference between a senolytic and a senomorphic?
While both senolytics and senomorphics reduce cellular senescence, they do so in different ways. Senolytics eliminate senescent cells, while senomorphics prevent them from spreading by inhibiting the release of SASP. [2] While the difference might seem nuanced, the two can actually have very different effects. By selectively killing senescent cells, senolytics reduce the overall cell count. Senomorphics, on the other hand, maintain the overall number of cells while reducing the number of senescent cells.Both senolytics and senomorphics have potential benefits and drawbacks, and their effectiveness and safety depend on the specific drug, the disease being targeted, and the patient population.
02
What are the risks and benefits of senolytics?
Like targeted missiles, senolytics seek out and eliminate senescent cells. This means they may help delay or even reverse age-related conditions. Preclinical and early clinical trials have shown promising results on various age-related diseases including osteoarthritis, atherosclerosis, and lung fibrosis.When it comes to downsides, senolytics may have the potential to miss their target and harm healthy cells, especially if they’re used for long periods or in combination with other drugs. Some evidence also shows that senolytics may not be effective against all types of senescent cells, which may limit the types of conditions that they can treat. Plus, because they simply kill senescent cells rather than treating the underlying causes of senescence, senolytics may not be a definitive cure for senescence-associated diseases. [3]
02
What are the risks and benefits of senolytics?
Like targeted missiles, senolytics seek out and eliminate senescent cells. This means they may help delay or even reverse age-related conditions. Preclinical and early clinical trials have shown promising results on various age-related diseases including osteoarthritis, atherosclerosis, and lung fibrosis.When it comes to downsides, senolytics may have the potential to miss their target and harm healthy cells, especially if they’re used for long periods or in combination with other drugs. Some evidence also shows that senolytics may not be effective against all types of senescent cells, which may limit the types of conditions that they can treat. Plus, because they simply kill senescent cells rather than treating the underlying causes of senescence, senolytics may not be a definitive cure for senescence-associated diseases. [3]
03
What are the risks and benefits of senomorphics?
Because they address the root causes of senescence by targeting multiple pathways, senomorphics may be slightly more versatile than senolytics–meaning they might be able to treat more conditions. Plus, because they don’t kill senescent cells, they come with less risk of inadvertently targeting healthy cells. They’re also considered easier to work with– because they do not need to penetrate cells, senomorphics may be easier to formulate into effective drugs or supplements that people can use.While senomorphics have a lot of upsides, they also have more complex and less-defined mechanisms of action, which may make it difficult to predict both their effects and potential side effects. And, because they may not be as effective as senolytics in reducing the number of senescent cells, they may show less pronounced benefits. [3]
03
What are the risks and benefits of senomorphics?
Because they address the root causes of senescence by targeting multiple pathways, senomorphics may be slightly more versatile than senolytics–meaning they might be able to treat more conditions. Plus, because they don’t kill senescent cells, they come with less risk of inadvertently targeting healthy cells. They’re also considered easier to work with– because they do not need to penetrate cells, senomorphics may be easier to formulate into effective drugs or supplements that people can use.While senomorphics have a lot of upsides, they also have more complex and less-defined mechanisms of action, which may make it difficult to predict both their effects and potential side effects. And, because they may not be as effective as senolytics in reducing the number of senescent cells, they may show less pronounced benefits. [3]
04
Is the OS-01 peptide a senolytic or senomorphic?
When we discovered that our OS-01 peptide reduced cellular senescence in ex vivo human skin samples, it was important for us to understand exactly how it works. Is it killing senescent cells like a senolytic or suppressing the spread of senescence like a senomorphic?To find out for sure, we analyzed key SASP markers, IL-6, CXCL1, and CXCL8, in in vitro skin cells and ex vivo human skin samples treated with OS-01. In in vitro skin cells, OS-01 significantly reduced IL-6 and CXCL1. In ex vivo human skin samples, it also reduced CXCL8 and showed a trend towards decreased IL6. This data shows that, because it reduces SASP markers, OS-01 should be considered a senomorphic. This means that OS-01 prevents pre-senescent cells from progressing into late senescence and accumulating within the skin [4] This is likely how the OS-01 peptide achieves its visible age-reversal benefits. By preventing the accumulation of senescent cells, OS-01 can support a key collagen production marker [4], reduce melanin deposits which cause hyperpigmentation*, and boost epidermal thickness [4]– helping your skin not only look younger, but also behave like younger skin.*Shown in ex vivo human skin samples
04
Is the OS-01 peptide a senolytic or senomorphic?
When we discovered that our OS-01 peptide reduced cellular senescence in ex vivo human skin samples, it was important for us to understand exactly how it works. Is it killing senescent cells like a senolytic or suppressing the spread of senescence like a senomorphic?To find out for sure, we analyzed key SASP markers, IL-6, CXCL1, and CXCL8, in in vitro skin cells and ex vivo human skin samples treated with OS-01. In in vitro skin cells, OS-01 significantly reduced IL-6 and CXCL1. In ex vivo human skin samples, it also reduced CXCL8 and showed a trend towards decreased IL6. This data shows that, because it reduces SASP markers, OS-01 should be considered a senomorphic. This means that OS-01 prevents pre-senescent cells from progressing into late senescence and accumulating within the skin [4] This is likely how the OS-01 peptide achieves its visible age-reversal benefits. By preventing the accumulation of senescent cells, OS-01 can support a key collagen production marker [4], reduce melanin deposits which cause hyperpigmentation*, and boost epidermal thickness [4]– helping your skin not only look younger, but also behave like younger skin.*Shown in ex vivo human skin samples
05
Looking ahead: the future of senotherapeutics
The development of senotherapeutics is still in its nascent stages. While scientists have identified a number of molecules capable of reducing senescence, more research is needed to understand exactly which diseases these molecules are capable of addressing. New breakthroughs are being made every day – keep an eye out for senolytics and senomorphics in the news as longevity researchers uncover more about their therapeutic potential.
05
Looking ahead: the future of senotherapeutics
The development of senotherapeutics is still in its nascent stages. While scientists have identified a number of molecules capable of reducing senescence, more research is needed to understand exactly which diseases these molecules are capable of addressing. New breakthroughs are being made every day – keep an eye out for senolytics and senomorphics in the news as longevity researchers uncover more about their therapeutic potential.
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Key Takeaways:
- Senotherapeutics are molecules like the OS-01 peptide that are capable of reducing cellular senescence, a central hallmark of aging.
- There are two major types of senotherapeutics: senolytics, which kill senescent cells and senomorphics, which contain the spread of senescent cells by blocking factors that would otherwise induce neighboring cells into senescence
- Both senomorphics and senolytics have potential benefits and drawbacks when compared to one another.
- Because it has been shown to reduce SASP markers rather than killing senescent cells, the OS-01 peptide can be considered a senomorphic.
- This is how OS-01 achieves its primary benefits, including its ability to reduce skin’s biological age. [4]
Key Takeaways:
- Senotherapeutics are molecules like the OS-01 peptide that are capable of reducing cellular senescence, a central hallmark of aging.
- There are two major types of senotherapeutics: senolytics, which kill senescent cells and senomorphics, which contain the spread of senescent cells by blocking factors that would otherwise induce neighboring cells into senescence
- Both senomorphics and senolytics have potential benefits and drawbacks when compared to one another.
- Because it has been shown to reduce SASP markers rather than killing senescent cells, the OS-01 peptide can be considered a senomorphic.
- This is how OS-01 achieves its primary benefits, including its ability to reduce skin’s biological age. [4]
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
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The Science of Sunscreen: Understanding the Optima...
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A Comprehensive Guide to Understanding the Differe...
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An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
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Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
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Dry Skin 101: How To Identify This Skin Type
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Developing a Skin Care Routine for Normal Skin: 4 ...
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Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
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A Comprehensive Guide to Understanding and Managin...
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How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
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How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
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How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
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Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
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8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
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Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
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Skin Microbiome: What It Is, Why it’s Important, A...
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The 101 Guide To Understanding Acne-Prone Skin
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OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
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101 Guide On The Benefits Of Cleansing Your Face
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Get to Know OneSkin’s Topical Supplements:
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How OneSkin Developed the OS-01 Peptide
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Tight Feeling Skin: 3 Reasons Why
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OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
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A Complete Guide to the 4 Stages of Wound Healing
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Celebrating Black History Month: A Discussion With...
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Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
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Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
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