How OS-01 EYE Supports the Ultra-Thin Skin Around the Eyes
6 min read
THE ONESKIN TEAM
February 28,2023
ONESKIN PRODUCTS, SKIN CARE
How OS-01 EYE Supports the Ultra-Thin Skin Around the Eyes
6 min read
THE ONESKIN TEAM
February 28,2023
ONESKIN PRODUCTS, SKIN CARE
Just a quick look at the skin around your eyes and you can tell it’s different from the skin just inches below it on your cheek. Maybe it looks softer or crinkles more easily. Maybe you notice more fine lines and wrinkles. Or maybe you see purple or green coloring under your eyes. All of these are signs of one undeniable fact: the skin under your eyes is much thinner than the skin on the rest of your face. In fact, the skin around the eyes is among the thinnest on the entire body.[1] Let’s take a closer look at why skin thickness matters and how our new OS-01 EYE was specifically formulated to support the delicate skin around the eyes.
Just a quick look at the skin around your eyes and you can tell it’s different from the skin just inches below it on your cheek. Maybe it looks softer or crinkles more easily. Maybe you notice more fine lines and wrinkles. Or maybe you see purple or green coloring under your eyes. All of these are signs of one undeniable fact: the skin under your eyes is much thinner than the skin on the rest of your face. In fact, the skin around the eyes is among the thinnest on the entire body.[1] Let’s take a closer look at why skin thickness matters and how our new OS-01 EYE was specifically formulated to support the delicate skin around the eyes.
01
Understanding Epidermal Thickness
The epidermis is the outermost layer of our skin and the thinnest of the three main skin layers. Responsible for protecting our bodies from the outside world, the epidermis is made up of 5 layers of its own, including the stratum corneum, which is sometimes called the skin barrier. This layer of the epidermis is made up of corneocytes, dead skin cells that protect the skin from environmental aggressors like UV light, pathogens, and pollutants. These dead skin cells are “glued” together by fats that keep water inside the skin and prevent dehydration. [2]
01
Understanding Epidermal Thickness
The epidermis is the outermost layer of our skin and the thinnest of the three main skin layers. Responsible for protecting our bodies from the outside world, the epidermis is made up of 5 layers of its own, including the stratum corneum, which is sometimes called the skin barrier. This layer of the epidermis is made up of corneocytes, dead skin cells that protect the skin from environmental aggressors like UV light, pathogens, and pollutants. These dead skin cells are “glued” together by fats that keep water inside the skin and prevent dehydration. [2]
02
The Impacts of Epidermal Thickness Around the Eyes
The skin around your eyes has a stratum corneum that is on average about 3 layers thick compared to 15+ layers on other areas.¹ When the stratum corneum is weaker, it experiences higher rates of transepidermal water loss and is more vulnerable to environmental aggressors that degrade skin firmness and resilience.[1] This may be the the reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [3,4]
02
The Impacts of Epidermal Thickness Around the Eyes
The skin around your eyes has a stratum corneum that is on average about 3 layers thick compared to 15+ layers on other areas.¹ When the stratum corneum is weaker, it experiences higher rates of transepidermal water loss and is more vulnerable to environmental aggressors that degrade skin firmness and resilience.[1] This may be the the reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [3,4]
03
How to Support Epidermal Thickness Around the Eyes
So how can you help support epidermal thickness in the super thin skin around your eyes? The answer is OS-01, our breakthrough peptide that’s been scientifically proven to increase epidermal thickness. [5,6]In a study, our scientists measured the epidermal thickness of ex vivo human skin samples from 35-year-old, 55-year-old, and 79-year-old donors before and after treatment with the OS-01 peptide. The results were astounding, with the epidermal thickness increasing by 16% in the 35-year-old skin samples, 28% in the 55-year-old skin samples, and 11% in the 79-year-old skin samples after exposure to the OS-01 peptide. These improvements included noticeable changes in the stratum corneum–the outermost dark purple layer in these histological images. [5,6]
03
How to Support Epidermal Thickness Around the Eyes
So how can you help support epidermal thickness in the super thin skin around your eyes? The answer is OS-01, our breakthrough peptide that’s been scientifically proven to increase epidermal thickness. [5,6]In a study, our scientists measured the epidermal thickness of ex vivo human skin samples from 35-year-old, 55-year-old, and 79-year-old donors before and after treatment with the OS-01 peptide. The results were astounding, with the epidermal thickness increasing by 16% in the 35-year-old skin samples, 28% in the 55-year-old skin samples, and 11% in the 79-year-old skin samples after exposure to the OS-01 peptide. These improvements included noticeable changes in the stratum corneum–the outermost dark purple layer in these histological images. [5,6]
Histology images of ex vivo human skin samples from 35, 55, and 79 year old donors exposed to the OS-01 peptide (12.5uM) (Zonari, et al, npj Aging, 2023).
Histology images of ex vivo human skin samples from 35, 55, and 79 year old donors exposed to the OS-01 peptide (12.5uM) (Zonari, et al, npj Aging, 2023).
Epidermal thickness analysis of ex vivo human skin samples (35, 55 and 79yr) after 5 days of treatment with 12.5uM OS-01 peptide revealed a significant increase upon treatment (Zonari, et al, npj Aging, 2023).
Epidermal thickness analysis of ex vivo human skin samples (35, 55 and 79yr) after 5 days of treatment with 12.5uM OS-01 peptide revealed a significant increase upon treatment (Zonari, et al, npj Aging, 2023).
04
Boost Collagen & Firmness Around the Eyes with OS-01 EYE
Formulated with the highest concentration of our OS-01 peptide, our new OS-01 EYE was specifically designed to address the thin skin around the eyes. In studies, OS-01 EYE has been shown to support the production and retention of collagen around the eyes [5]–counteracting one of the main effects of a weaker stratum corneum.Our scientists exposed ex vivo human eyelid skin samples to either nothing (No Treatment) or OS-01 EYE, then performed an expression analysis to evaluate the effect of OS-01 EYE on markers associated with collagen production, COL1A1, and degradation, MMP1. Samples exposed to OS-01 EYE showed increased COL1A1 and decreased MMP1. [5] This means that OS-01 EYE supports skin’s firmness around the eyes by both promoting collagen synthesis and preventing its degradation.In a 12-week clinical study, OS-01 EYE's firming effects was confirmed. OS-01 EYE is also clinically validated to boost barrier function, hydration, elasticity, tone and texture, and radiance. [5]
04
Boost Collagen & Firmness Around the Eyes with OS-01 EYE
Formulated with the highest concentration of our OS-01 peptide, our new OS-01 EYE was specifically designed to address the thin skin around the eyes. In studies, OS-01 EYE has been shown to support the production and retention of collagen around the eyes [5]–counteracting one of the main effects of a weaker stratum corneum.Our scientists exposed ex vivo human eyelid skin samples to either nothing (No Treatment) or OS-01 EYE, then performed an expression analysis to evaluate the effect of OS-01 EYE on markers associated with collagen production, COL1A1, and degradation, MMP1. Samples exposed to OS-01 EYE showed increased COL1A1 and decreased MMP1. [5] This means that OS-01 EYE supports skin’s firmness around the eyes by both promoting collagen synthesis and preventing its degradation.In a 12-week clinical study, OS-01 EYE's firming effects was confirmed. OS-01 EYE is also clinically validated to boost barrier function, hydration, elasticity, tone and texture, and radiance. [5]
Related Products
Related Products
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
Key Takeaways:
- The delicate skin around the eyes has a stratum corneum that is up to 5x thinner than other areas of the face and body.
- The stratum corneum is a layer of the epidermis keeps water inside the skin, preventing dehydration.
- A weaker stratum corneum leaves the skin more vulnerable to environmental aggressors which may be a reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss.
- The OS-01 peptide has been proven to improve epidermal thickness in ex vivo human skin samples. [5,6]
- Our new OS-01 EYE Topical Supplement contains the highest concentration of the OS-01 peptide and has been shown to promote collagen biosynthesis and retention at the molecular level in lab studies on ex vivo eyelid skin. [5]
Key Takeaways:
- The delicate skin around the eyes has a stratum corneum that is up to 5x thinner than other areas of the face and body.
- The stratum corneum is a layer of the epidermis keeps water inside the skin, preventing dehydration.
- A weaker stratum corneum leaves the skin more vulnerable to environmental aggressors which may be a reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss.
- The OS-01 peptide has been proven to improve epidermal thickness in ex vivo human skin samples. [5,6]
- Our new OS-01 EYE Topical Supplement contains the highest concentration of the OS-01 peptide and has been shown to promote collagen biosynthesis and retention at the molecular level in lab studies on ex vivo eyelid skin. [5]
References
- https://link.springer.com/referencework/10.1007/978-3-662-47398-6
- https://my.clevelandclinic.org/health/body/21901-epidermis
- https://doi.org/10.1016/j.jaad.2016.02.112
- Vrcek, Ivan et al. “Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment.” Journal of cutaneous and aesthetic surgery vol. 9,2 (2016): 65-72. doi:10.4103/0974-2077.184046
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
References
- https://link.springer.com/referencework/10.1007/978-3-662-47398-6
- https://my.clevelandclinic.org/health/body/21901-epidermis
- https://doi.org/10.1016/j.jaad.2016.02.112
- Vrcek, Ivan et al. “Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment.” Journal of cutaneous and aesthetic surgery vol. 9,2 (2016): 65-72. doi:10.4103/0974-2077.184046
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
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The Science of Sunscreen: Understanding the Optima...
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A Comprehensive Guide to Understanding the Differe...
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An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
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Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
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Dry Skin 101: How To Identify This Skin Type
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Developing a Skin Care Routine for Normal Skin: 4 ...
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Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
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A Comprehensive Guide to Understanding and Managin...
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How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
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How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
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How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
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Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
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8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
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Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
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Skin Microbiome: What It Is, Why it’s Important, A...
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The 101 Guide To Understanding Acne-Prone Skin
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OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
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101 Guide On The Benefits Of Cleansing Your Face
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Get to Know OneSkin’s Topical Supplements:
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How OneSkin Developed the OS-01 Peptide
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Tight Feeling Skin: 3 Reasons Why
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OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
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A Complete Guide to the 4 Stages of Wound Healing
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Celebrating Black History Month: A Discussion With...
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Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
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Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
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