OneSkin Notable Mention: Dave Asprey's The Human Upgrade Podcast Episode 994 | How A Peptide Gets Under Your Skin To Combat Aging with Dave Asprey

3 min read

THE ONESKIN TEAM
August 12,2022
EXPERTS

OneSkin Notable Mention: Dave Asprey's The Human Upgrade Podcast Episode 994 | How A Peptide Gets Under Your Skin To Combat Aging with Dave Asprey

3 min read

THE ONESKIN TEAM
August 12,2022
EXPERTS
Dubbed “the father of biohacking,” Dave Asprey is a renowned pioneer in the emerging biohacking space, which is quickly gaining popularity among those who believe science can unlock the tools to living a healthier, longer, and more fulfilling life - something OneSkin is very aligned with! Asprey has written and published several books outlining scientifically-backed hacks that promote system-wide health and longevity. He is also the founder of Bulletproof, a company well-known for their performance-oriented approach to nutrition.Among Asprey's multiple media and entrepreneurial ventures, The Human Upgrade podcast is quickly gaining a cult-like following, as Asprey discusses how to maximize human performance using science, technology and personal development tools with experts in their respective fields.We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, to discuss the science behind OneSkin and our proprietary peptide, OS-01.You can listen to the full podcast episode, hereto learn more about daveasprey, or read some of the key points discussed in this episode below!
Dubbed “the father of biohacking,” Dave Asprey is a renowned pioneer in the emerging biohacking space, which is quickly gaining popularity among those who believe science can unlock the tools to living a healthier, longer, and more fulfilling life - something OneSkin is very aligned with! Asprey has written and published several books outlining scientifically-backed hacks that promote system-wide health and longevity. He is also the founder of Bulletproof, a company well-known for their performance-oriented approach to nutrition.Among Asprey's multiple media and entrepreneurial ventures, The Human Upgrade podcast is quickly gaining a cult-like following, as Asprey discusses how to maximize human performance using science, technology and personal development tools with experts in their respective fields.We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, to discuss the science behind OneSkin and our proprietary peptide, OS-01.You can listen to the full podcast episode, hereto learn more about daveasprey, or read some of the key points discussed in this episode below!
01

OneSkin is a skin longevity company.

01

OneSkin is a skin longevity company.

Oliviera: “We spent 5 years [in] product development… trying to understand, if skin aging is a disease, what’s causing that disease?… What’s the target that we should intervene with?” [1]In OneSkin’s earliest stage, our founding team of PhD longevity scientists leveraged their expertise in skin biology and tissue engineering to develop a unique testing platform utilizing ex vivo human skin and MolClock - the first skin-specific molecular clock - to measure the biological age of skin. By utilizing this platform to test the efficacy of existing products and ingredients for their rejuvenating capabilities on human skin, our founders quickly discovered that most products didn’t affect the biological age of the skin - a problem they would eventually set out to solve.Oliveira: “What we realized during this process is that most of the products don’t really reverse the aging of the skin. They can improve the appearance of the skin, make the skin plumper, more hydrated but they’re not effective at rejuvenating the skin.” [1]This discovery led OneSkin to pivot from being a platform-based research company to a direct-to-consumer pioneer in the longevity space. Utilizing the same platform that allowed them to test existing products and ingredients, OneSkin’s founders set out to discover new molecules that could reverse the biological age of skin. Their goal? To develop a molecule capable of reducing cellular senescence - one of the nine hallmarks of aging and a key driver in skin aging in particular - thereby reversing the biological age of skin.

Oliviera: “We spent 5 years [in] product development… trying to understand, if skin aging is a disease, what’s causing that disease?… What’s the target that we should intervene with?” [1]In OneSkin’s earliest stage, our founding team of PhD longevity scientists leveraged their expertise in skin biology and tissue engineering to develop a unique testing platform utilizing ex vivo human skin and MolClock - the first skin-specific molecular clock - to measure the biological age of skin. By utilizing this platform to test the efficacy of existing products and ingredients for their rejuvenating capabilities on human skin, our founders quickly discovered that most products didn’t affect the biological age of the skin - a problem they would eventually set out to solve.Oliveira: “What we realized during this process is that most of the products don’t really reverse the aging of the skin. They can improve the appearance of the skin, make the skin plumper, more hydrated but they’re not effective at rejuvenating the skin.” [1]This discovery led OneSkin to pivot from being a platform-based research company to a direct-to-consumer pioneer in the longevity space. Utilizing the same platform that allowed them to test existing products and ingredients, OneSkin’s founders set out to discover new molecules that could reverse the biological age of skin. Their goal? To develop a molecule capable of reducing cellular senescence - one of the nine hallmarks of aging and a key driver in skin aging in particular - thereby reversing the biological age of skin.
02

Senescent cell accumulation is a key driver of skin aging.

Throughout life, our cells age and accumulate damage, eventually driving each cell to either die or enter into a state of cellular senescence, dubbing them senescent or zombie cells. When left to linger, senescent cells release harmful inflammatory factors that accelerate aging and skin deterioration. As we age, our bodies become less efficient at clearing away senescent cells, and their subsequent accumulation is one of the primary reasons why we age. This is especially true for skin, which is why cellular senescence became OneSkin’s primary target in developing our lead compound, eventually leading us to develop the OS-01 peptide. (Read more about senescent cells hereto learn more about what is senescence!)Asprey: “This happens in your skin and your face.” [1]Oliviera: “In your whole body, but primarily in your face because you have more exposure. You are exposed to UV radiation and several environmental stressors.” [1]Since your skin is most exposed to environmental stressors, it experiences more senescent cell accumulation. Oliviera discusses how OneSkin went on to identify the molecules best suited for eliminating senescent cells in the skin.Oliviera: “We decided to develop a screening platform to test over 1,000 different peptides until we found the one that has the highest or the greatest ability to decrease the accumulation of senescent cells. That's how we got to this peptide that we call OS-01.” [1]
02

Senescent cell accumulation is a key driver of skin aging.

Throughout life, our cells age and accumulate damage, eventually driving each cell to either die or enter into a state of cellular senescence, dubbing them senescent or zombie cells. When left to linger, senescent cells release harmful inflammatory factors that accelerate aging and skin deterioration. As we age, our bodies become less efficient at clearing away senescent cells, and their subsequent accumulation is one of the primary reasons why we age. This is especially true for skin, which is why cellular senescence became OneSkin’s primary target in developing our lead compound, eventually leading us to develop the OS-01 peptide. (Read more about senescent cells hereto learn more about what is senescence!)Asprey: “This happens in your skin and your face.” [1]Oliviera: “In your whole body, but primarily in your face because you have more exposure. You are exposed to UV radiation and several environmental stressors.” [1]Since your skin is most exposed to environmental stressors, it experiences more senescent cell accumulation. Oliviera discusses how OneSkin went on to identify the molecules best suited for eliminating senescent cells in the skin.Oliviera: “We decided to develop a screening platform to test over 1,000 different peptides until we found the one that has the highest or the greatest ability to decrease the accumulation of senescent cells. That's how we got to this peptide that we call OS-01.” [1]
03

What makes peptides, and OS-01, so special?

Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their ingredients’ inability to penetrate the skin barrier. The epidermal layer is very good at keeping large molecules (eg. most collagen) out of the inner, or dermal layers, preventing them from having measurable effects on the skin.That’s why OneSkin takes advantage of the small size and chemical properties of peptides which are signalling molecules that can penetrate the epidermal layer and enter the dermal layer. Depending on the peptide, from there they can effect the cell health by promoting repair pathways, stimulating proiferation and the natural production of collagen and hyaluronic acid, and so much more. [2]
03

What makes peptides, and OS-01, so special?

Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their ingredients’ inability to penetrate the skin barrier. The epidermal layer is very good at keeping large molecules (eg. most collagen) out of the inner, or dermal layers, preventing them from having measurable effects on the skin.That’s why OneSkin takes advantage of the small size and chemical properties of peptides which are signalling molecules that can penetrate the epidermal layer and enter the dermal layer. Depending on the peptide, from there they can effect the cell health by promoting repair pathways, stimulating proiferation and the natural production of collagen and hyaluronic acid, and so much more. [2]
04

OneSkin’s Proprietary Peptide: OS-01.

OneSkin’s proprietary peptide, OS-01, is scientifically proven to penetrate the skin and support the natural production of molecules that are critical to maintaining skin health with age. [2]Oliviera: “We have actually tested the penetration, how much of the peptide actually goes into the dermis. So one of the studies that we do in our lab, we apply the cream on top of skin biopsies… after 24 hours we separate the [dermal layers] from the [epidermal layers] and we measure how much peptide gets into the [dermal layers]... that’s when we want to see the collagen production and the stimulation of fibroblasts and so on.” [1]OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer at an unprecedented rate, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid, and collagen, along with promoting cellular repair mechanisms. [2]Oliviera: “This peptide has a very interesting profile because again, it’s small enough to penetrate. It’s super safe, we have done all the safety studies. There is no toxicity, no irritation. We have done all the recommended studies by the FDA for personal care products. And it has this beautiful effect of reducing the accumulation of senescent cells and reduces the release of inflammatory markers and increases the production of hyaluronic acid, elastin and collagen.” [1]
04

OneSkin’s Proprietary Peptide: OS-01.

OneSkin’s proprietary peptide, OS-01, is scientifically proven to penetrate the skin and support the natural production of molecules that are critical to maintaining skin health with age. [2]Oliviera: “We have actually tested the penetration, how much of the peptide actually goes into the dermis. So one of the studies that we do in our lab, we apply the cream on top of skin biopsies… after 24 hours we separate the [dermal layers] from the [epidermal layers] and we measure how much peptide gets into the [dermal layers]... that’s when we want to see the collagen production and the stimulation of fibroblasts and so on.” [1]OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer at an unprecedented rate, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid, and collagen, along with promoting cellular repair mechanisms. [2]Oliviera: “This peptide has a very interesting profile because again, it’s small enough to penetrate. It’s super safe, we have done all the safety studies. There is no toxicity, no irritation. We have done all the recommended studies by the FDA for personal care products. And it has this beautiful effect of reducing the accumulation of senescent cells and reduces the release of inflammatory markers and increases the production of hyaluronic acid, elastin and collagen.” [1]
05

We are so honored!

We are both thrilled and honored to have our CEO spotlighted on The Human Upgrade podcast. At OneSkin, we set a higher standard for skin care, tackling skin aging at the cellular level. Our star peptide not only reduces the accumulation of senescent cells, one of the main drivers of skin aging, but also penetrates deep into skin to stimulate the production of important molecules for skin health, ultimately reducing the biological age of skin! [2]
05

We are so honored!

We are both thrilled and honored to have our CEO spotlighted on The Human Upgrade podcast. At OneSkin, we set a higher standard for skin care, tackling skin aging at the cellular level. Our star peptide not only reduces the accumulation of senescent cells, one of the main drivers of skin aging, but also penetrates deep into skin to stimulate the production of important molecules for skin health, ultimately reducing the biological age of skin! [2]
Key Takeaways:
  • Dubbed “the father of biohacking”, Dave Asprey is a renowned pioneer in the emerging biohacking space.
  • We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, onto his podcast, The Human Upgrade.
  • The accumulation of senescent cells is one of the primary reasons we our skin ages, and OneSkin’s primary target.
  • Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their inability to penetrate the skin barrier.
  • OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer to effect real change in skin, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid and collagen. [2]
Key Takeaways:
  • Dubbed “the father of biohacking”, Dave Asprey is a renowned pioneer in the emerging biohacking space.
  • We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, onto his podcast, The Human Upgrade.
  • The accumulation of senescent cells is one of the primary reasons we our skin ages, and OneSkin’s primary target.
  • Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their inability to penetrate the skin barrier.
  • OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer to effect real change in skin, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid and collagen. [2]
References
References

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging - One Skin Technologies
Healthspan: A New Way To Think About Aging

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How To Turn Your Skin Care Resolutions Into Skin C...
What Does Clean Beauty Mean, And Why Does Safe Bea...
Winter Skincare - How To Prevent Dry Skin this Sea...
What Are Chemical Peels & Are There Alternatives?
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What are Zombie Cells & How Can We Remove Them?
Collagen For Menopause: Why Is It Necessary For Healthy Skin Aging?
Collagen During Menopause: Is It Necessary For Hea...
Behind the Seal: How OneSkin Achieved the National...
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Full OneSkin Regimen
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The Connection Between Mental Health, Age Percepti...
OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
MolClock: Using Epigenetics to Measure The Biologi...
How OS-01 BODY Pauses Biological Aging For Overall...
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Biohacking Healthy Aging: The Organs of Longevity
Does Niacinamide Help With Acne & Scarring?
5 Reasons Why Zinc Oxide Is Our Preferred UV Filte...
6 Common In-Office Skin Treatments to Complement y...
What is Microneedling & Are There Alternatives?
How to Protect Against and Reverse Collagen Loss
Why Your Neck, Décolletage, and Hands Need Extra C...
What's the Connection Between Dehydration and Dry ...
How to Tighten Facial Skin Without Surgery
Exploring Alternatives to Botox
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Recognizing Signs of Over-Exfoliated Skin
Healing Over-Exfoliated Skin: How to Treat Over-Ex...
OS-01 BODY SPF and OS-01 BODY: Even Better Togethe...
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Is Talc Bad for Skin? 7 Things You Need to Know
How Do We Know the OS-01 Peptide is Safe?
What Is Lanolin and Is It Bad for Your Skin?
Non-Comedogenic vs Comedogenic Skin Care Products
Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
Petrolatum: Is it Safe or Harmful for Your Skin?
How Much Sunscreen to Apply
What Do Antioxidants Do For Skin and Why Should Yo...
Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
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How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
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Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
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Addressing the Need for Indoor Sun Protection
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Pollution
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Understanding the Relationship Between Sleep and U...
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How to Improve Gut Microbiome
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What’s the Connection Between Quality Sleep and Lo...
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The Microbiome Diet and Its Effects on Skin
The Microbiome Diet and Its Effects on Skin
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Cold Exposure: Hype or Longevity Boosting?
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How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
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What Causes Dark Circles Under and Around Your Eye...
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How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
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Diving into Dermis: Functions and Significance
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Ceramides For Skin: Everything You Need to Know ne...
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How to Address Stomach Wrinkles For Smoother Skin
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What is Skin Cycling
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Do You Know What Clinical Claims Really Mean?
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What is Tinted Sunscreen?
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2 Types of Wrinkles and Tips for Treating Them
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Hallmarks Of Aging - One Skin Technologies
Hallmarks of Aging
What Is Sensitive Skin
What is Sensitive Skin?
How OS-01 Works on Mature Skin
How OS-01 Works on Mature Skin
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Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
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How Do You Know When to Stop Using Retinol?
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Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
Why We Want Skin To Be More, Not Less
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Yes, You Need Sunscreen During Winter
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Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
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What is the Best Skin Care Regimen for Aging Skin
What is the Best Skin Care Regimen for Aging Skin?
6 Benefits of Jojoba Oil
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
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What are the Benefits of Sulforaphane?
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Allantoin For Skin: A Comprehensive Guide
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A Simplified Guide To The Different Skin Texture Types
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
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Skin Microbiome: What It Is, Why it’s Important, A...
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What Foods Cause Acne and Which Fight Against It?
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What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
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101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
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Five Common Skin Problems Experienced in Perimenop...
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OS-

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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Optimize Your Health
How to Use Peptides In Your Skincare Regimen to Op...
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What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
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Three Ways To Extend Your Skinspan Starting With Y...
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What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Longevity
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
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Cell Turnover & Why It Slows As We Age
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101 Guide To Skin Tightening
101 Guide To Skin Tightening + 7 Noninvasive Metho...
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How to Reduce Skin Inflammation & Redness
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The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
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4 Foods To Avoid During Wound Healing & Why
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Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barrier
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care and Longevity
Representation of the Black Community in Skin Care...
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Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Health Is The New Wealth - One Skin Technologies
Health Is The New Wealth
Sleep: Nature’s Restart Button? - One Skin Technologies
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging - One Skin Technologies
Healthspan: A New Way To Think About Aging