OneSkin Notable Mention: Dave Asprey's The Human Upgrade Podcast Episode 994 | How A Peptide Gets Under Your Skin To Combat Aging with Dave Asprey
3 min read
THE ONESKIN TEAM
August 12,2022
EXPERTS
OneSkin Notable Mention: Dave Asprey's The Human Upgrade Podcast Episode 994 | How A Peptide Gets Under Your Skin To Combat Aging with Dave Asprey
3 min read
THE ONESKIN TEAM
August 12,2022
EXPERTS
Dubbed “the father of biohacking,” Dave Asprey is a renowned pioneer in the emerging biohacking space, which is quickly gaining popularity among those who believe science can unlock the tools to living a healthier, longer, and more fulfilling life - something OneSkin is very aligned with! Asprey has written and published several books outlining scientifically-backed hacks that promote system-wide health and longevity. He is also the founder of Bulletproof, a company well-known for their performance-oriented approach to nutrition.Among Asprey's multiple media and entrepreneurial ventures, The Human Upgrade podcast is quickly gaining a cult-like following, as Asprey discusses how to maximize human performance using science, technology and personal development tools with experts in their respective fields.We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, to discuss the science behind OneSkin and our proprietary peptide, OS-01.You can listen to the full podcast episode, hereto learn more about daveasprey, or read some of the key points discussed in this episode below!
Dubbed “the father of biohacking,” Dave Asprey is a renowned pioneer in the emerging biohacking space, which is quickly gaining popularity among those who believe science can unlock the tools to living a healthier, longer, and more fulfilling life - something OneSkin is very aligned with! Asprey has written and published several books outlining scientifically-backed hacks that promote system-wide health and longevity. He is also the founder of Bulletproof, a company well-known for their performance-oriented approach to nutrition.Among Asprey's multiple media and entrepreneurial ventures, The Human Upgrade podcast is quickly gaining a cult-like following, as Asprey discusses how to maximize human performance using science, technology and personal development tools with experts in their respective fields.We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, to discuss the science behind OneSkin and our proprietary peptide, OS-01.You can listen to the full podcast episode, hereto learn more about daveasprey, or read some of the key points discussed in this episode below!
01
OneSkin is a skin longevity company.
01
OneSkin is a skin longevity company.
Oliviera: “We spent 5 years [in] product development… trying to understand, if skin aging is a disease, what’s causing that disease?… What’s the target that we should intervene with?” [1]In OneSkin’s earliest stage, our founding team of PhD longevity scientists leveraged their expertise in skin biology and tissue engineering to develop a unique testing platform utilizing ex vivo human skin and MolClock - the first skin-specific molecular clock - to measure the biological age of skin. By utilizing this platform to test the efficacy of existing products and ingredients for their rejuvenating capabilities on human skin, our founders quickly discovered that most products didn’t affect the biological age of the skin - a problem they would eventually set out to solve.Oliveira: “What we realized during this process is that most of the products don’t really reverse the aging of the skin. They can improve the appearance of the skin, make the skin plumper, more hydrated but they’re not effective at rejuvenating the skin.” [1]This discovery led OneSkin to pivot from being a platform-based research company to a direct-to-consumer pioneer in the longevity space. Utilizing the same platform that allowed them to test existing products and ingredients, OneSkin’s founders set out to discover new molecules that could reverse the biological age of skin. Their goal? To develop a molecule capable of reducing cellular senescence - one of the nine hallmarks of aging and a key driver in skin aging in particular - thereby reversing the biological age of skin.
Oliviera: “We spent 5 years [in] product development… trying to understand, if skin aging is a disease, what’s causing that disease?… What’s the target that we should intervene with?” [1]In OneSkin’s earliest stage, our founding team of PhD longevity scientists leveraged their expertise in skin biology and tissue engineering to develop a unique testing platform utilizing ex vivo human skin and MolClock - the first skin-specific molecular clock - to measure the biological age of skin. By utilizing this platform to test the efficacy of existing products and ingredients for their rejuvenating capabilities on human skin, our founders quickly discovered that most products didn’t affect the biological age of the skin - a problem they would eventually set out to solve.Oliveira: “What we realized during this process is that most of the products don’t really reverse the aging of the skin. They can improve the appearance of the skin, make the skin plumper, more hydrated but they’re not effective at rejuvenating the skin.” [1]This discovery led OneSkin to pivot from being a platform-based research company to a direct-to-consumer pioneer in the longevity space. Utilizing the same platform that allowed them to test existing products and ingredients, OneSkin’s founders set out to discover new molecules that could reverse the biological age of skin. Their goal? To develop a molecule capable of reducing cellular senescence - one of the nine hallmarks of aging and a key driver in skin aging in particular - thereby reversing the biological age of skin.
02
Senescent cell accumulation is a key driver of skin aging.
Throughout life, our cells age and accumulate damage, eventually driving each cell to either die or enter into a state of cellular senescence, dubbing them senescent or zombie cells. When left to linger, senescent cells release harmful inflammatory factors that accelerate aging and skin deterioration. As we age, our bodies become less efficient at clearing away senescent cells, and their subsequent accumulation is one of the primary reasons why we age. This is especially true for skin, which is why cellular senescence became OneSkin’s primary target in developing our lead compound, eventually leading us to develop the OS-01 peptide. (Read more about senescent cells hereto learn more about what is senescence!)Asprey: “This happens in your skin and your face.” [1]Oliviera: “In your whole body, but primarily in your face because you have more exposure. You are exposed to UV radiation and several environmental stressors.” [1]Since your skin is most exposed to environmental stressors, it experiences more senescent cell accumulation. Oliviera discusses how OneSkin went on to identify the molecules best suited for eliminating senescent cells in the skin.Oliviera: “We decided to develop a screening platform to test over 1,000 different peptides until we found the one that has the highest or the greatest ability to decrease the accumulation of senescent cells. That's how we got to this peptide that we call OS-01.” [1]
02
Senescent cell accumulation is a key driver of skin aging.
Throughout life, our cells age and accumulate damage, eventually driving each cell to either die or enter into a state of cellular senescence, dubbing them senescent or zombie cells. When left to linger, senescent cells release harmful inflammatory factors that accelerate aging and skin deterioration. As we age, our bodies become less efficient at clearing away senescent cells, and their subsequent accumulation is one of the primary reasons why we age. This is especially true for skin, which is why cellular senescence became OneSkin’s primary target in developing our lead compound, eventually leading us to develop the OS-01 peptide. (Read more about senescent cells hereto learn more about what is senescence!)Asprey: “This happens in your skin and your face.” [1]Oliviera: “In your whole body, but primarily in your face because you have more exposure. You are exposed to UV radiation and several environmental stressors.” [1]Since your skin is most exposed to environmental stressors, it experiences more senescent cell accumulation. Oliviera discusses how OneSkin went on to identify the molecules best suited for eliminating senescent cells in the skin.Oliviera: “We decided to develop a screening platform to test over 1,000 different peptides until we found the one that has the highest or the greatest ability to decrease the accumulation of senescent cells. That's how we got to this peptide that we call OS-01.” [1]
03
What makes peptides, and OS-01, so special?
Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their ingredients’ inability to penetrate the skin barrier. The epidermal layer is very good at keeping large molecules (eg. most collagen) out of the inner, or dermal layers, preventing them from having measurable effects on the skin.That’s why OneSkin takes advantage of the small size and chemical properties of peptides which are signalling molecules that can penetrate the epidermal layer and enter the dermal layer. Depending on the peptide, from there they can effect the cell health by promoting repair pathways, stimulating proiferation and the natural production of collagen and hyaluronic acid, and so much more. [2]
03
What makes peptides, and OS-01, so special?
Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their ingredients’ inability to penetrate the skin barrier. The epidermal layer is very good at keeping large molecules (eg. most collagen) out of the inner, or dermal layers, preventing them from having measurable effects on the skin.That’s why OneSkin takes advantage of the small size and chemical properties of peptides which are signalling molecules that can penetrate the epidermal layer and enter the dermal layer. Depending on the peptide, from there they can effect the cell health by promoting repair pathways, stimulating proiferation and the natural production of collagen and hyaluronic acid, and so much more. [2]
04
OneSkin’s Proprietary Peptide: OS-01.
OneSkin’s proprietary peptide, OS-01, is scientifically proven to penetrate the skin and support the natural production of molecules that are critical to maintaining skin health with age. [2]Oliviera: “We have actually tested the penetration, how much of the peptide actually goes into the dermis. So one of the studies that we do in our lab, we apply the cream on top of skin biopsies… after 24 hours we separate the [dermal layers] from the [epidermal layers] and we measure how much peptide gets into the [dermal layers]... that’s when we want to see the collagen production and the stimulation of fibroblasts and so on.” [1]OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer at an unprecedented rate, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid, and collagen, along with promoting cellular repair mechanisms. [2]Oliviera: “This peptide has a very interesting profile because again, it’s small enough to penetrate. It’s super safe, we have done all the safety studies. There is no toxicity, no irritation. We have done all the recommended studies by the FDA for personal care products. And it has this beautiful effect of reducing the accumulation of senescent cells and reduces the release of inflammatory markers and increases the production of hyaluronic acid, elastin and collagen.” [1]
04
OneSkin’s Proprietary Peptide: OS-01.
OneSkin’s proprietary peptide, OS-01, is scientifically proven to penetrate the skin and support the natural production of molecules that are critical to maintaining skin health with age. [2]Oliviera: “We have actually tested the penetration, how much of the peptide actually goes into the dermis. So one of the studies that we do in our lab, we apply the cream on top of skin biopsies… after 24 hours we separate the [dermal layers] from the [epidermal layers] and we measure how much peptide gets into the [dermal layers]... that’s when we want to see the collagen production and the stimulation of fibroblasts and so on.” [1]OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer at an unprecedented rate, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid, and collagen, along with promoting cellular repair mechanisms. [2]Oliviera: “This peptide has a very interesting profile because again, it’s small enough to penetrate. It’s super safe, we have done all the safety studies. There is no toxicity, no irritation. We have done all the recommended studies by the FDA for personal care products. And it has this beautiful effect of reducing the accumulation of senescent cells and reduces the release of inflammatory markers and increases the production of hyaluronic acid, elastin and collagen.” [1]
Related Products
Related Products
05
We are so honored!
We are both thrilled and honored to have our CEO spotlighted on The Human Upgrade podcast. At OneSkin, we set a higher standard for skin care, tackling skin aging at the cellular level. Our star peptide not only reduces the accumulation of senescent cells, one of the main drivers of skin aging, but also penetrates deep into skin to stimulate the production of important molecules for skin health, ultimately reducing the biological age of skin! [2]
05
We are so honored!
We are both thrilled and honored to have our CEO spotlighted on The Human Upgrade podcast. At OneSkin, we set a higher standard for skin care, tackling skin aging at the cellular level. Our star peptide not only reduces the accumulation of senescent cells, one of the main drivers of skin aging, but also penetrates deep into skin to stimulate the production of important molecules for skin health, ultimately reducing the biological age of skin! [2]
Key Takeaways:
- Dubbed “the father of biohacking”, Dave Asprey is a renowned pioneer in the emerging biohacking space.
- We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, onto his podcast, The Human Upgrade.
- The accumulation of senescent cells is one of the primary reasons we our skin ages, and OneSkin’s primary target.
- Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their inability to penetrate the skin barrier.
- OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer to effect real change in skin, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid and collagen. [2]
Key Takeaways:
- Dubbed “the father of biohacking”, Dave Asprey is a renowned pioneer in the emerging biohacking space.
- We are proud to announce that Dave Asprey recently invited OneSkin’s CEO and Co-Founder, Carolina Reis Oliveira Ph.D, onto his podcast, The Human Upgrade.
- The accumulation of senescent cells is one of the primary reasons we our skin ages, and OneSkin’s primary target.
- Though many topical skin care products contain potentially beneficial ingredients, a large number of those products have little to no influence on the skin, due to their inability to penetrate the skin barrier.
- OS-01 wasn’t a champion amongst 800+ peptides for nothing! Not only does it penetrate to the dermis layer to effect real change in skin, it also reduces the accumulation of senescent cells, and stimulates the production of important molecules for skin health including hyaluronic acid and collagen. [2]
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging