The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01
10 min read
FEB 29, 2024 - BY THE ONESKIN TEAM
February 29,2024
FROM THE ONESKIN LAB; INGREDIENTS
The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01
10 min read
FEB 29, 2024 - BY THE ONESKIN TEAM
February 29,2024
FROM THE ONESKIN LAB; INGREDIENTS
We’re on a mission to change the way people think about skin health and longevity. And while that mission always starts with our R&D platform, the most advanced and sophisticated tool to measure the efficacy of age reversal molecules on skin, we know that real life results can sometimes differ from those in the lab.That’s why we chose to validate the effects of OS-01 FACE and the OS-01 peptide on skin in human subjects, leading to our 12-week double-blind, split face clinical study, which has now been published in the Journal of Cosmetic Dermatology.This clinical study confirms the benefits that we have been predicting ever since we discovered OS-01’s unprecedented ability to reduce the senescent burden in skin: Topical application of the OS-01 peptide improves barrier function, protects against dehydration, reduces appearance of wrinkles, and improves skin texture and radiance. (1) Basically, OS-01 turns back the clock on skin’s biological age, thanks to its ability to clear out the damaged, aging cells that cause your skin to look older. (2)
We’re on a mission to change the way people think about skin health and longevity. And while that mission always starts with our R&D platform, the most advanced and sophisticated tool to measure the efficacy of age reversal molecules on skin, we know that real life results can sometimes differ from those in the lab.That’s why we chose to validate the effects of OS-01 FACE and the OS-01 peptide on skin in human subjects, leading to our 12-week double-blind, split face clinical study, which has now been published in the Journal of Cosmetic Dermatology.This clinical study confirms the benefits that we have been predicting ever since we discovered OS-01’s unprecedented ability to reduce the senescent burden in skin: Topical application of the OS-01 peptide improves barrier function, protects against dehydration, reduces appearance of wrinkles, and improves skin texture and radiance. (1) Basically, OS-01 turns back the clock on skin’s biological age, thanks to its ability to clear out the damaged, aging cells that cause your skin to look older. (2)
01
The Hypothesis
Our lab studies on ex vivo human skin samples and in vitro skin cells proved that the OS-01 peptide can reduce senescent burden in skin and improve skin health profiles. (2) And since senescence in skin is significantly associated with facial wrinkles and perceived age (3), we hypothesized that applying the OS-01 peptide on human skin would reduce the visible signs of aging.
01
The Hypothesis
Our lab studies on ex vivo human skin samples and in vitro skin cells proved that the OS-01 peptide can reduce senescent burden in skin and improve skin health profiles. (2) And since senescence in skin is significantly associated with facial wrinkles and perceived age (3), we hypothesized that applying the OS-01 peptide on human skin would reduce the visible signs of aging.
02
The Methods (and Why They’re Unique)
This study stands out for a few reasons. First, it didn’t just look at the effects of OS-01 FACE on skin; it specifically evaluated the effects of the OS-01 peptide on skin. Using a split-face study, participants applied OS-01 FACE to one side of their face and an identical formulation without the peptide (termed the “vehicle” formulation) to the other. With this approach, it would be clear that any improvements between each side were a direct result of the OS-01 peptide.Given that OS-01 FACE is packed with bioactive ingredients that have their own benefits, comparing it against an identical, peptide-free version really put OS-01 in the spotlight. This method isn’t something you see every day in the skin care industry, making our study not only rigorous, but also quite unique.
02
The Methods (and Why They’re Unique)
This study stands out for a few reasons. First, it didn’t just look at the effects of OS-01 FACE on skin; it specifically evaluated the effects of the OS-01 peptide on skin. Using a split-face study, participants applied OS-01 FACE to one side of their face and an identical formulation without the peptide (termed the “vehicle” formulation) to the other. With this approach, it would be clear that any improvements between each side were a direct result of the OS-01 peptide.Given that OS-01 FACE is packed with bioactive ingredients that have their own benefits, comparing it against an identical, peptide-free version really put OS-01 in the spotlight. This method isn’t something you see every day in the skin care industry, making our study not only rigorous, but also quite unique.
Figure 1. Split-face design
In the table below, you’ll notice the only difference is the presence or absence of the OS-01 peptide:
Figure 1. Split-face design
In the table below, you’ll notice the only difference is the presence or absence of the OS-01 peptide:
Another reason this study is unique? Instrumental analyses were used whenever possible, which unlike expert clinical evaluation and self-perception offer completely objective results. Of course, some results can’t be measured and the way people feel about their skin matters too. That’s why we included expert analysis and personal perception results as well. To minimize bias, our study was double-blinded, meaning that neither the researchers nor the participants knew which side of their face received the OS-01 formula, and which got the lookalike without the peptide.
Another reason this study is unique? Instrumental analyses were used whenever possible, which unlike expert clinical evaluation and self-perception offer completely objective results. Of course, some results can’t be measured and the way people feel about their skin matters too. That’s why we included expert analysis and personal perception results as well. To minimize bias, our study was double-blinded, meaning that neither the researchers nor the participants knew which side of their face received the OS-01 formula, and which got the lookalike without the peptide.
03
How the Study was Conducted
The group of subjects included 22 females aged 47 to 65 years with dry, normal, and combination skin types. Each participant applied the formulas, as outlined above, twice daily over 12 weeks to respective sides of their faces. They were also provided a standard face cleanser (Cetaphil Gentle Cleanser) and sunscreen (Neutrogena Oil-Free Moisture SPF 35) to use on both sides of their faces throughout the study. This ensured that any changes were due to the formulas being tested.
The Analysis Methods
At baseline (0 months), 3 months, and 6 months, the skin on each side of the subjects’ faces were independently analyzed in three ways:1. Instrumental evaluation:
- Barrier function: We used a vapometer to measure how quickly water evaporates from the skin, also known as trans-epidermal water loss (TEWL). A lower TEWL indicates a stronger skin barrier that keeps hydration in better.
- Wrinkle indentation and skin texture/smoothness: An Antera 3D imaging instrument provided a 3D reconstruction of the skin’s surface, allowing us to measure the depth and texture of lines and wrinkles on the subjects’ skin.
- Radiance: High-resolution images were captured using VISIA CR in various lighting settings to assess skin’s radiance, then calculated with analysis software.
- Fine lines/wrinkles
- Skin tone (color evenness)
- Texture/smoothness (visual analysis)
- Firmness (visual analysis)
- Elasticity (tactile analysis)
- Skin pores
- Radiance/luminosity
- Overall appearance
03
How the Study was Conducted
The group of subjects included 22 females aged 47 to 65 years with dry, normal, and combination skin types. Each participant applied the formulas, as outlined above, twice daily over 12 weeks to respective sides of their faces. They were also provided a standard face cleanser (Cetaphil Gentle Cleanser) and sunscreen (Neutrogena Oil-Free Moisture SPF 35) to use on both sides of their faces throughout the study. This ensured that any changes were due to the formulas being tested.
The Analysis Methods
At baseline (0 months), 3 months, and 6 months, the skin on each side of the subjects’ faces were independently analyzed in three ways:1. Instrumental evaluation:
- Barrier function: We used a vapometer to measure how quickly water evaporates from the skin, also known as trans-epidermal water loss (TEWL). A lower TEWL indicates a stronger skin barrier that keeps hydration in better.
- Wrinkle indentation and skin texture/smoothness: An Antera 3D imaging instrument provided a 3D reconstruction of the skin’s surface, allowing us to measure the depth and texture of lines and wrinkles on the subjects’ skin.
- Radiance: High-resolution images were captured using VISIA CR in various lighting settings to assess skin’s radiance, then calculated with analysis software.
- Fine lines/wrinkles
- Skin tone (color evenness)
- Texture/smoothness (visual analysis)
- Firmness (visual analysis)
- Elasticity (tactile analysis)
- Skin pores
- Radiance/luminosity
- Overall appearance
04
The Results
As scientists, we were particularly drawn to the instrumental data as it provided objective measurements. To further validate these findings, we considered the results from our expert clinical evaluations and participant self-perception questionnaire.Below is a summary of the instrumentation results.
04
The Results
As scientists, we were particularly drawn to the instrumental data as it provided objective measurements. To further validate these findings, we considered the results from our expert clinical evaluations and participant self-perception questionnaire.Below is a summary of the instrumentation results.
Adapted from Table 2 (Zonari, et al., Journal of Cosmetic Dermatology, 2024)*Statistically significant
Adapted from Table 2 (Zonari, et al., Journal of Cosmetic Dermatology, 2024)*Statistically significant
Barrier Function
Skin treated with OS-01 FACE presented a significantly lower TEWL (14% at 6 weeks and 18% at 12 weeks) compared to baseline. This indicates a significant increase in the skin’s barrier function. In contrast, skin treated with the vehicle formulation showed minimal change in TEWL compared to baseline. This highlights the direct impact of the OS-01 peptide on skin barrier improvement.It’s worth noting that this study was conducted in a dry climate during the winter months, when skin is typically more dehydrated. (4) While the vehicle formula didn’t impact TEWL according to vapometer readings, 84% of participants reported an improvement in skin hydration after 12 weeks and 100% reporting an improvement after 6 weeks for both formulations, which is likely a result of the product’s supporting ingredients.The improved skin barrier is thought to be the result of the OS-01 peptide’s ability to increase epidermal thickness and stimulate the expression of HAS2, a key biomarker associated with hyaluronic acid synthesis, as we’ve previously observed in ex vivo human skin samples and 3D human skin models. (2) Additionally, the peptide’s capacity to reduce senescent burden in skin and promote cell proliferation, as shown by increasing the expression of cell proliferation biomarker, Ki67, likely contributes to this result. (2)A stronger skin barrier not only improves appearance, it provides better protection against allergies (5), atopic dermatitis (6), and even systemic inflammation (7).
Barrier Function
Skin treated with OS-01 FACE presented a significantly lower TEWL (14% at 6 weeks and 18% at 12 weeks) compared to baseline. This indicates a significant increase in the skin’s barrier function. In contrast, skin treated with the vehicle formulation showed minimal change in TEWL compared to baseline. This highlights the direct impact of the OS-01 peptide on skin barrier improvement.It’s worth noting that this study was conducted in a dry climate during the winter months, when skin is typically more dehydrated. (4) While the vehicle formula didn’t impact TEWL according to vapometer readings, 84% of participants reported an improvement in skin hydration after 12 weeks and 100% reporting an improvement after 6 weeks for both formulations, which is likely a result of the product’s supporting ingredients.The improved skin barrier is thought to be the result of the OS-01 peptide’s ability to increase epidermal thickness and stimulate the expression of HAS2, a key biomarker associated with hyaluronic acid synthesis, as we’ve previously observed in ex vivo human skin samples and 3D human skin models. (2) Additionally, the peptide’s capacity to reduce senescent burden in skin and promote cell proliferation, as shown by increasing the expression of cell proliferation biomarker, Ki67, likely contributes to this result. (2)A stronger skin barrier not only improves appearance, it provides better protection against allergies (5), atopic dermatitis (6), and even systemic inflammation (7).
Wrinkle Indentation and Skin Texture
In just 6 weeks, OS-01 FACE showed a reduction in wrinkle indentation, compared to the vehicle formulation, which was very close to statistically significant. Conversely, the vehicle formulation showed no change after 6 weeks or 12 weeks.Observe the visible results of OS-01 FACE (OS-01 formulation) and the vehicle formulation below.
Wrinkle Indentation and Skin Texture
In just 6 weeks, OS-01 FACE showed a reduction in wrinkle indentation, compared to the vehicle formulation, which was very close to statistically significant. Conversely, the vehicle formulation showed no change after 6 weeks or 12 weeks.Observe the visible results of OS-01 FACE (OS-01 formulation) and the vehicle formulation below.
Figure 2. Representative images highlgihting skin wrinkles in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treatment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
After 12 weeks, skin texture showed a significant improvement with OS-01 FACE compared to the baseline — something that wasn’t observed on the side treated with the vehicle formulation. Check out the visible results of OS-01 FACE (OS-01 formulation) and the vehicle formulation below.
Figure 2. Representative images highlgihting skin wrinkles in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treatment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
After 12 weeks, skin texture showed a significant improvement with OS-01 FACE compared to the baseline — something that wasn’t observed on the side treated with the vehicle formulation. Check out the visible results of OS-01 FACE (OS-01 formulation) and the vehicle formulation below.
Figure 3. Representative images highlighting skin texture in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treatment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
Expert clinical graders confirmed the enhancements in wrinkle and pore appearance, as well as skin texture, noting improvements from both formulations over time. Not only that, 81% of participants noticed that their skin was softer — results that spanned both formulations.
Figure 3. Representative images highlighting skin texture in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treatment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
Expert clinical graders confirmed the enhancements in wrinkle and pore appearance, as well as skin texture, noting improvements from both formulations over time. Not only that, 81% of participants noticed that their skin was softer — results that spanned both formulations.
Radiance
OS-01 FACE significantly improved radiance by +16%, while the vehicle formulation showed a non significant improvement. This was confirmed by the expert clinical graders who noted significant improvements in skin radiance, tone, and overall appearance on both sides of the face. Subjects also observed an improvement in their skin’s radiance and overall appearance.See the results in the images below.
Radiance
OS-01 FACE significantly improved radiance by +16%, while the vehicle formulation showed a non significant improvement. This was confirmed by the expert clinical graders who noted significant improvements in skin radiance, tone, and overall appearance on both sides of the face. Subjects also observed an improvement in their skin’s radiance and overall appearance.See the results in the images below.
Figure 4. Representative images higlighting skin radiance in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treattment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
Figure 4. Representative images higlighting skin radiance in two subjects after 12 weeks of OS-01 FACE or vehicle formulation treattment. (Zonari, et al., Journal of Cosmetic Dermatology, 2024)
05
Conclusion
While our previous lab studies confirmed the effects of the OS-01 peptide on skin at the cellular and molecular levels by reducing senescence (2), this study takes a giant leap forward by validating its impact beyond the lab. Here’s a recap:
- Senescent cells cause visible signs of aging by altering cellular function, increasing tissue inflammation, impacting skin pigmentation, and changing the composition of the extracellular matrix which includes collagen and hyaluronic acid (8)
- Instrumental analysis revealed that the formula with OS-01 significantly improved skin’s barrier function and texture, improved skin radiance, and promoted a progressive reduction in wrinkles compared to the vehicle formulation (the peptide-free version of OS-01 FACE)
- Both formulations contain beneficial ingredients such as Pracaxi oil, Andiroba oil, Niacinamide, Pau mulato Oleic Extract, Allantoin, and Hyaluronic Acid, which is why both groups noticed an improvement in skin hydration, firmness and elasticity, radiance, texture and general appearance
05
Conclusion
While our previous lab studies confirmed the effects of the OS-01 peptide on skin at the cellular and molecular levels by reducing senescence (2), this study takes a giant leap forward by validating its impact beyond the lab. Here’s a recap:
- Senescent cells cause visible signs of aging by altering cellular function, increasing tissue inflammation, impacting skin pigmentation, and changing the composition of the extracellular matrix which includes collagen and hyaluronic acid (8)
- Instrumental analysis revealed that the formula with OS-01 significantly improved skin’s barrier function and texture, improved skin radiance, and promoted a progressive reduction in wrinkles compared to the vehicle formulation (the peptide-free version of OS-01 FACE)
- Both formulations contain beneficial ingredients such as Pracaxi oil, Andiroba oil, Niacinamide, Pau mulato Oleic Extract, Allantoin, and Hyaluronic Acid, which is why both groups noticed an improvement in skin hydration, firmness and elasticity, radiance, texture and general appearance
Related Products
Related Products
References
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
- https://www.nature.com/articles/s41514-023-00109-1
- https://pubmed.ncbi.nlm.nih.gov/26286607/
- https://karger.com/exd/article-abstract/1/1/32/133809/The-Winter-Season-Affects-More-Severely-the-Facial?redirectedFrom=fulltext
- https://pubmed.ncbi.nlm.nih.gov/29153780/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850335/
- https://pubmed.ncbi.nlm.nih.gov/30835878/
- https://pubmed.ncbi.nlm.nih.gov/34487917/
References
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
- https://www.nature.com/articles/s41514-023-00109-1
- https://pubmed.ncbi.nlm.nih.gov/26286607/
- https://karger.com/exd/article-abstract/1/1/32/133809/The-Winter-Season-Affects-More-Severely-the-Facial?redirectedFrom=fulltext
- https://pubmed.ncbi.nlm.nih.gov/29153780/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850335/
- https://pubmed.ncbi.nlm.nih.gov/30835878/
- https://pubmed.ncbi.nlm.nih.gov/34487917/
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging
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Why Men Shouldn’t Ignore Skin Care: What’s Missing...
Navigating Skin Longevity: The Industry, The Scien...
What’s the Difference Between Dry and Dehydrated S...
How to Keep Your Hair Healthy and Strong During Pe...
What are Zombie Cells & How Can We Remove Them?
Collagen During Menopause: Is It Necessary For Hea...
Behind the Seal: How OneSkin Achieved the National...
Sun Sensitivity And Menopause: Protecting Your Cha...
Peptides Vs Growth Factors: Which is Better For Sk...
Hyperpigmentation and Menopause: Understanding and...
Skin Care is Health Care: Why Skin Care is the Key...
How Do Our Products Work Together?
The Connection Between Mental Health, Age Percepti...
MolClock: Using Epigenetics to Measure The Biologi...
How OS-01 BODY Pauses Biological Aging For Overall...
Biohacking Healthy Aging: The Organs of Longevity
Does Niacinamide Help With Acne & Scarring?
5 Reasons Why Zinc Oxide Is Our Preferred UV Filte...
6 Common In-Office Skin Treatments to Complement y...
What is Microneedling & Are There Alternatives?
How to Protect Against and Reverse Collagen Loss
Why Your Neck, Décolletage, and Hands Need Extra C...
What's the Connection Between Dehydration and Dry ...
How to Tighten Facial Skin Without Surgery
Exploring Alternatives to Botox
Best Practices for Moisturizing After Exfoliating
Recognizing Signs of Over-Exfoliated Skin
Healing Over-Exfoliated Skin: How to Treat Over-Ex...
OS-01 BODY SPF and OS-01 BODY: Even Better Togethe...
Introducing OS-01 BODY SPF: Triple power protectio...
Is Talc Bad for Skin? 7 Things You Need to Know
How Do We Know the OS-01 Peptide is Safe?
What Is Lanolin and Is It Bad for Your Skin?
Non-Comedogenic vs Comedogenic Skin Care Products
Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
Petrolatum: Is it Safe or Harmful for Your Skin?
How Much Sunscreen to Apply
What Do Antioxidants Do For Skin and Why Should Yo...
Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging