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Skin Care Is Health Care: OS-01 BODY’s 12-Week Clinically Validated Results Are The Proof

Skin Care Is Health Care: OS-01 BODY’s 12-Week Clinically Validated Results Are The Proof

Founded by a team of researchers, OneSkin was born in the lab, just like our products. However, our goal has always been to bridge the gap between scientific data and real-world efficacy. That's why we conduct clinical studiesβ€”to move beyond lab-based results and dive into the tangible impact our topical supplements can have on your skin’s appearance and overall health.

In our 12-week clinical study, recently published in the Journal of Cosmetic Dermatology, we tested the efficacy of OS-01 BODY on a variety of skin health factors, including hydration, texture, and barrier function. Even more exciting, we tested the impact of OS-01 BODY on systemic health markers like systemic inflammation and biological age. Given that skin is your largest organ, its health has broad implications on systemic wellbeing, and this study proves that.

What Was Our Hypothesis?

Typically, theΒ skin barrier, a thin layer of skin cells and lipids, keeps most sources of inflammation, like UV radiation and pollution, out. However, when this barrier becomes damaged or weakened, it can lead to chronic inflammation in the skin that spreads throughout the body, potentially accelerating the process of whole-body aging.

Our hypothesis was that improvements in skin barrier function would, in turn, improve metrics of overall health, like systemic inflammation.

How Did We Put OS-01 BODY to The (Clinical) Test

Our 12-week double-blind clinical study included 52 participants, ages 60 to 90 years old. Half the group (Group A, n=27) used OS-01 BODY twice daily, while the other half (Group B, n=25) used a control moisturizer twice daily. Both groups used a standardized cleanser and avoided other skin care products during the trial period to limit confounding variables.

We measured skin hydration, barrier function, and pH through specialized instrumentsβ€”three markers strongly associated with the skin's ability to stay protected against environmental stressors. But we didn’t just rely on objective data. We asked participants how they felt about their skin after using OS-01 BODY using a self-perception questionnaire at baseline and weeks 4 and 12. After all, it’s one thing to have data proving a product works; it’s another for people using it to tell us how they feel it's working.

Blood samples were also collected to measure the effects of OS-01 BODY on systemic, whole-body aging at baseline levels and after 12 weeks of use. Since aged and damaged skin releases inflammatory factors called cytokines that can spread throughout the body, the effects of OS-01 BODY on critical biomarkers of systemic inflammation and aging could be measured by measuring cytokine levels in participants' blood. [3,4]

Additionally, the study monitored the biological age of participants using GlycanAge, a third-party test that analyzes glycosylationβ€”a process where complex sugar molecules called glycans attach to antibodies associated with your immune response, impairing their function. Glycans attached to one of these antibodies, immunoglobulin G (IgG), change with age in predictable ways and can reflect the state of the immune system and inflammation. [5] Measuring these levels before and after treatment gives us an idea of how much their bodies have aged relative to their starting point.

What Were The Results Of OS-01 BODY’s Clinical Trial?

Instrumental Skin Analysis

After 12 weeks of using OS-01 BODY, participants showed significant improvements in hydration and skin barrier function and maintained normal pH levels. Here’s a breakdown of the data:

  • Hydration: Up 38.34% on forearm skin and 38.38% on the upper arm*
  • Skin barrier: Up 41.49% on forearm skin and 34.73% on the upper arm**
  • Skin pH: No significant change was observed in the OS-01 group***

Self-Perception Surveys

How people feel about their skin can be just as important as qualitative improvements that may be hard to notice. OS-01 BODY didn't disappoint, further confirming the results of our instrumental analysis. Here's what our participants had to say after 12 weeks of use:

  • 70.37% saw a clear enhancement in general skin appearance
  • 92.59% reported significantly improved skin hydration
  • 70.37% noticed smoother, more refined skin texture

When compared to the control group, OS-01 BODY results were superior on all measured and self-reported metrics, indicating the improved benefits when using OneSkin’s patented peptide.

Systemic Cytokine Levels

While visible enhancements were observed, the results of OS-01 BODY are more than just skin deep. Participants using OS-01 BODY showed a reduction in overall inflammatory markers (cytokines), including a significant decrease in IL-8. In contrast, the control group showed a slight increase in inflammation, with significant rises in TNF-Ι‘ and IFN-Ξ³ levels.

This promising trend confirms what we’ve suspected for some time – that stronger and healthier skin better protects your body from external factors, which may contribute to lower levels of systemic or chronic inflammation. While further study is needed, these results indicate that OS-01 BODY may reduce systemic inflammation by strengthening your skin barrier.

And because this type of inflammation is a leading cause of age-related diseases, such as cardiovascular disease and dementia, using OS-01 BODY could be a new way to extend your health span. [2]

Glycan Age to Test Biological Age

Interestingly, participants using OS-01 BODY did not show a relative change in biological age. While subjects were expected to age by about +0.25 years, those treated with the OS-01 formula presented an average change of βˆ’0.07 years, suggesting a slowed rate of biological aging.

In contrast, researchers observed that the biological age of the group using the control moisturizer increased by an average of +0.72 years. While these results were not statistically significant due to the small sample size, they represent a first step in validating our hypothesis that the systemic application of OS-01 BODY can slow down certain forms of whole body aging.

Saftey

While our lab testing has confirmed the safety profile of the main active ingredient in OS-01 BODY, the OS-01 peptide, we wanted to confirm that it only affects the skin and does not enter the bloodstream. Blood tests of participants were measured after 12 weeks and found no presence of OS-01 in the participants' bloodstream.

This further validates our hypothesis that OS-01 is not leading to the systemic benefits we saw during testing, but rather a bolstered skin barrier.

Why Our R&D Process is Different

One of our key differentiators is our cutting-edge research and development platform. Every product (including OS-01 BODY) starts in the lab. Each ingredient is tested individually on human skin samples, 3D skin models, and cells, then tested again as a whole to ensure our products improve skin health and longevity at the cellular and molecular levels. [1]

During lab testing, OS-01 BODY was found to increase epidermal thickness up to 40%.

Once we understand how they impact skin cells in a controlled setting, we move on to beta testing, allowing us to see how our products work in everyday scenarios. Finally, we conduct clinical studies to validate our lab and real-world findings.

Conclusion

We already understood the benefits of OS-01 BODY in the lab. However, the results of our 12-week clinical study make one thing clear: OS-01 BODY is much more than just a moisturizer. It’s a topical supplement that actively supports healthier, younger-acting skin, which can have system-wide benefits. From improved hydration for dry skin to a stronger skin barrier and lower inflammation biomarkers, OS-01 BODY is clinically validated to give your largest organ the support it needs.

Looking for a deeper dive into the science behind our products? Check out our published research or explore the data backing up our claims!

Key Takeaways

  • We test all our products using both scientific and clinical studies, so we have a comprehensive understanding of the results at the cellular level and in real life
  • During this clinical study, researchers observed improvements in skin hydration, skin barrier function, and systemic cytokine levels in participants who used OS-01 BODY twice a day for 12 weeks
  • Up to 72% of participants who used OS-01 BODY twice a day for 12 weeks noticed an improvement in the texture and overall appearance of their skin

References

Disclaimers

*Measured by corneometer at 12 weeks vs baseline **Measured by tewameter at 12 weeks vs. baseline ***Measured by Skin pH-Meter at 12 weeks vs. baseline

Last Updated April 21, 2025

Reviewed by

Alessandra Zonari

Alessandra Zonari

PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.