Peptides vs Retinol: Is One Better For Increasing Skin Longevity?
4 min read
May 16,2022
SKIN CARE, SKIN SCIENCE
Peptides vs Retinol: Is One Better For Increasing Skin Longevity?
4 min read
May 16,2022
SKIN CARE, SKIN SCIENCE
Peptides and retinol are two of the biggest players in the skin space with much of their celebrity status coming from their use in the “anti-aging” industry. But how promising is each active ingredient for skin longevity and which one – if not both – should you integrate into your skin health routine?Wondering, what is a peptide? Or, what do retinoids do? Let’s start with the basics:
Peptides and retinol are two of the biggest players in the skin space with much of their celebrity status coming from their use in the “anti-aging” industry. But how promising is each active ingredient for skin longevity and which one – if not both – should you integrate into your skin health routine?Wondering, what is a peptide? Or, what do retinoids do? Let’s start with the basics:
01
What is a peptide?
Peptides are small biological molecules containing two or more amino acids arranged in a chain-like fashion. Peptides that are linked together naturally become arranged in complex structures to form proteins (aka “polypeptides”), which are the molecules responsible for nearly every cell function. Collagen is the most abundant protein in the human body and is vital to skin health and longevity. The dermis (middle) layer of the skin is particularly important for skin longevity as this is where collagen-producing fibroblast cells reside. It’s widely accepted that collagen synthesis and subsequent collagen levels in the skin decrease with age, leading to changes in skin, such as fragility, increased fine lines and wrinkles, sagging, and loss of elasticity. [1]Peptide research and discovery is an exciting space for cutting-edge skincare. But, not all peptides are created equal. As direct supplementation of collagen to skin is difficult, skincare science has cleverly developed peptides that can promote collagen synthesis on a genetic level to rejuvenate skin from the inside out.Here are a few big players that are gaining attention for their collagen-boosting properties.
- Copper peptides are a type of carrier peptide that work together with antioxidant enzymes in the skin to protect collagen. This active ingredient also fights reactive oxygen species that can wreak havoc on other important molecules like DNA. [2]
- Palmitoyl pentapeptide-4 is another popular peptide to hit the market. Professionally known as Matrixyl, this ingredient has been shown to reduce wrinkles and increase skin elasticity in several biologically-relevant experiments. [3]
- OS-01 is a novel peptide that was originally developed in the OneSkin lab. This peptide is the first of its kind to reduce the level of cellular senescence in skin (which would otherwise result in the accumulation of “zombie” cells directly shown to cause skin damage and aging). The OS-01 peptide has been scientifically proven to increase key biomarkers associated with collagen and hyaluronic acid production. It also decreases biomarkers associated with aging and inflammation. [4]
01
What is a peptide?
Peptides are small biological molecules containing two or more amino acids arranged in a chain-like fashion. Peptides that are linked together naturally become arranged in complex structures to form proteins (aka “polypeptides”), which are the molecules responsible for nearly every cell function. Collagen is the most abundant protein in the human body and is vital to skin health and longevity. The dermis (middle) layer of the skin is particularly important for skin longevity as this is where collagen-producing fibroblast cells reside. It’s widely accepted that collagen synthesis and subsequent collagen levels in the skin decrease with age, leading to changes in skin, such as fragility, increased fine lines and wrinkles, sagging, and loss of elasticity. [1]Peptide research and discovery is an exciting space for cutting-edge skincare. But, not all peptides are created equal. As direct supplementation of collagen to skin is difficult, skincare science has cleverly developed peptides that can promote collagen synthesis on a genetic level to rejuvenate skin from the inside out.Here are a few big players that are gaining attention for their collagen-boosting properties.
- Copper peptides are a type of carrier peptide that work together with antioxidant enzymes in the skin to protect collagen. This active ingredient also fights reactive oxygen species that can wreak havoc on other important molecules like DNA. [2]
- Palmitoyl pentapeptide-4 is another popular peptide to hit the market. Professionally known as Matrixyl, this ingredient has been shown to reduce wrinkles and increase skin elasticity in several biologically-relevant experiments. [3]
- OS-01 is a novel peptide that was originally developed in the OneSkin lab. This peptide is the first of its kind to reduce the level of cellular senescence in skin (which would otherwise result in the accumulation of “zombie” cells directly shown to cause skin damage and aging). The OS-01 peptide has been scientifically proven to increase key biomarkers associated with collagen and hyaluronic acid production. It also decreases biomarkers associated with aging and inflammation. [4]
02
What is Retinol?
Retinol is a modified form of vitamin A, also known as retinoic acid. Vitamin A is crucial for central nervous system and immune system homeostasis, and even has antioxidant properties. [5] Retinoids can be broadly found on ingredients list as tretinoin, retinol, retinal, retinyl palmitate, or retinyl acetate – and depending on their concentration – they may induce negative side effects on your skin. Retinoids work by stimulating skin cell turnover and boosting collagen synthesis. By using retinol, dead skin cells at the surface of the skin are replaced with younger cells. Unfortunately, this rapid cell turnover can weaken the skin barrier temporarily after each use, leaving your skin and body vulnerable for a brief period of time, so proper skin care following use of retinol is critical for allowing the skin barrier to recover.Some stronger retinoids are prescription strength; only given by dermatologists to treat more stubborn skin conditions such as severe acne, fine lines, and/or dark spots to even out skin tone and improve overall skin texture. However, retinoid use can also (commonly) result in, skin irritation, skin dryness, skin sensitivity, skin flaking, and increased sensitivity to the sun, especially in the acute phase after initial use.
02
What is Retinol?
Retinol is a modified form of vitamin A, also known as retinoic acid. Vitamin A is crucial for central nervous system and immune system homeostasis, and even has antioxidant properties. [5] Retinoids can be broadly found on ingredients list as tretinoin, retinol, retinal, retinyl palmitate, or retinyl acetate – and depending on their concentration – they may induce negative side effects on your skin. Retinoids work by stimulating skin cell turnover and boosting collagen synthesis. By using retinol, dead skin cells at the surface of the skin are replaced with younger cells. Unfortunately, this rapid cell turnover can weaken the skin barrier temporarily after each use, leaving your skin and body vulnerable for a brief period of time, so proper skin care following use of retinol is critical for allowing the skin barrier to recover.Some stronger retinoids are prescription strength; only given by dermatologists to treat more stubborn skin conditions such as severe acne, fine lines, and/or dark spots to even out skin tone and improve overall skin texture. However, retinoid use can also (commonly) result in, skin irritation, skin dryness, skin sensitivity, skin flaking, and increased sensitivity to the sun, especially in the acute phase after initial use.
03
Are peptides better for certain skin types?
Given retinol’s harsh effects, certain skin types (especially sensitive skin) may not work well with any vitamin A derivatives. Additionally, you should avoid using retinol products if your skin is consistently exposed to the sun.Peptides, on the other hand, are often suitable for any skin type.
03
Are peptides better for certain skin types?
Given retinol’s harsh effects, certain skin types (especially sensitive skin) may not work well with any vitamin A derivatives. Additionally, you should avoid using retinol products if your skin is consistently exposed to the sun.Peptides, on the other hand, are often suitable for any skin type.
04
Do peptides and retinol serve a similar purpose?
The benefits of peptides can be remarkably similar to those of retinol in terms of collagen synthesis and skin rejuvenation, and often with little to no negative side effects. Therefore, if you want the rejuvenation benefits of retinol without the negative side effects, a peptide moisturizer may be your answer.
04
Do peptides and retinol serve a similar purpose?
The benefits of peptides can be remarkably similar to those of retinol in terms of collagen synthesis and skin rejuvenation, and often with little to no negative side effects. Therefore, if you want the rejuvenation benefits of retinol without the negative side effects, a peptide moisturizer may be your answer.
05
Are peptides better than retinol and why?
OneSkin’s proprietary peptide, OS-01, has been studied against retinol and found to induce similar benefits with none of the harsh side effects. In fact, when tested against retinol on human skin samples in the OneSkin lab, the OS-01 peptide increased a key biomarker associated with collagen production similar to the level induced by retinol. Perhaps more important, retinol significantly increased biomarkers associated with aging and inflammation, while the OS-01 peptide reliably decreased the activity of those same biomarkers. [4] It should be noted, however, that these effects were seen in skin after 5 days of treatment, therefore they represent the acute effects of each product. If you are concerned about the side effects that come with retinol use and their impact on your skin health, but still want the rejuvenation benefits of improved collagen production, consider using OneSkin's OS-01 FACE. Additionally, OS-01 FACE can be used as a complement to retinol, as it is clinically validated to boost barrier function and skin hydration, helping to counteract the harsh effects of retinol. [5]
05
Are peptides better than retinol and why?
OneSkin’s proprietary peptide, OS-01, has been studied against retinol and found to induce similar benefits with none of the harsh side effects. In fact, when tested against retinol on human skin samples in the OneSkin lab, the OS-01 peptide increased a key biomarker associated with collagen production similar to the level induced by retinol. Perhaps more important, retinol significantly increased biomarkers associated with aging and inflammation, while the OS-01 peptide reliably decreased the activity of those same biomarkers. [4] It should be noted, however, that these effects were seen in skin after 5 days of treatment, therefore they represent the acute effects of each product. If you are concerned about the side effects that come with retinol use and their impact on your skin health, but still want the rejuvenation benefits of improved collagen production, consider using OneSkin's OS-01 FACE. Additionally, OS-01 FACE can be used as a complement to retinol, as it is clinically validated to boost barrier function and skin hydration, helping to counteract the harsh effects of retinol. [5]
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07
Are peptides or Vitamin A a better ingredient for healthy skin longevity?
So who wins in the skin longevity showdown? The jury is still out, but the scientists at OneSkin have shown that the OS-01 peptide may provide similar benefits with less downside.Retinol can be unsuitable for those with sensitive or reactive skin. In contrast, OneSkin’s OS-01 peptide reliability improves internal and external skin health markers, even on sensitive skin. Additionally, the OS-01 peptide is the first peptide proven to decrease skin’s biological age, thereby extending the length of time that skin is healthy and functional. [4]
07
Are peptides or Vitamin A a better ingredient for healthy skin longevity?
So who wins in the skin longevity showdown? The jury is still out, but the scientists at OneSkin have shown that the OS-01 peptide may provide similar benefits with less downside.Retinol can be unsuitable for those with sensitive or reactive skin. In contrast, OneSkin’s OS-01 peptide reliability improves internal and external skin health markers, even on sensitive skin. Additionally, the OS-01 peptide is the first peptide proven to decrease skin’s biological age, thereby extending the length of time that skin is healthy and functional. [4]
08
Can peptides replace retinol and everyday use?
Both retinol and peptides have been shown to fight the signs of skin aging. But choosing one skin care ingredient over the other depends on what skin concern you are trying to treat.Peptides still have a ways to go in terms of testing en masse compared to numerous, published scientific studies performed with retinol. That being said, peptides are more skin-friendly than retinol by a long shot, due to their more moisturizing nature. This can make them more amenable to everyday use. On the other hand, retinol can be quite effective (yet harsh!) at treating acne, evening skin tone, and lessening the appearance of dark spots. Can peptides and retinol be used in conjunction?Peptide-based products that are scientifically backed, such as OS-01’s Topical Supplements, will pair well with retinol as it can counteract some of retinol’s negative side effects.
08
Can peptides replace retinol and everyday use?
Both retinol and peptides have been shown to fight the signs of skin aging. But choosing one skin care ingredient over the other depends on what skin concern you are trying to treat.Peptides still have a ways to go in terms of testing en masse compared to numerous, published scientific studies performed with retinol. That being said, peptides are more skin-friendly than retinol by a long shot, due to their more moisturizing nature. This can make them more amenable to everyday use. On the other hand, retinol can be quite effective (yet harsh!) at treating acne, evening skin tone, and lessening the appearance of dark spots. Can peptides and retinol be used in conjunction?Peptide-based products that are scientifically backed, such as OS-01’s Topical Supplements, will pair well with retinol as it can counteract some of retinol’s negative side effects.
Key Takeaways:
- Age-associated decrease in collagen levels in the skin causes visible signs of aging, including loss of elasticity and fine lines/wrinkles.
- Peptides’ anti-aging benefits come from their ability to promote collagen synthesis, among other benefits depending on the peptide
- Retinol improves collagen synthesis in skin, but often at the expense of skin dryness, inflammation, and sun sensitivity.
- Peptides are generally more gentle and moisturizing than retinol and therefore a better choice for those with a more sensitive skin type.
- The OS-01 peptide is the first peptide scientifically proven to reduce skin’s biological age.
Key Takeaways:
- Age-associated decrease in collagen levels in the skin causes visible signs of aging, including loss of elasticity and fine lines/wrinkles.
- Peptides’ anti-aging benefits come from their ability to promote collagen synthesis, among other benefits depending on the peptide
- Retinol improves collagen synthesis in skin, but often at the expense of skin dryness, inflammation, and sun sensitivity.
- Peptides are generally more gentle and moisturizing than retinol and therefore a better choice for those with a more sensitive skin type.
- The OS-01 peptide is the first peptide scientifically proven to reduce skin’s biological age.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Addressing the Need for Indoor Sun Protection
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OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
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Exploring the Effects of Quality Sleep on Your Ski...
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The Microbiome Diet and Its Effects on Skin
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How to Protect Your Skin from Everyday Environment...
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What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
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How to Travel with Skin Care Products
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The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
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Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
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Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
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Three Ways To Extend Your Skinspan Starting With Y...
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The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
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Cell Turnover & Why It Slows As We Age
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101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
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How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
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Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
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Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging