PREP enhances the effects of OS-01 FACE, and the proof is in the data
2 min read
THE ONESKIN TEAM
October 05,2023
ONESKIN PRODUCTS
PREP enhances the effects of OS-01 FACE, and the proof is in the data
2 min read
THE ONESKIN TEAM
October 05,2023
ONESKIN PRODUCTS
What’s the one skin care step that can make or break your routine? Cleansing! While most cleansers remove surface-level dirt and impurities, the right cleanser can also improve the penetration of whatever products you apply next–giving you better results from the products you already use. That’s why OneSkin developed PREP: a gentle daily cleanser for all skin types that’s scientifically proven to optimize the effectiveness of OS-01 FACE.
What’s the one skin care step that can make or break your routine? Cleansing! While most cleansers remove surface-level dirt and impurities, the right cleanser can also improve the penetration of whatever products you apply next–giving you better results from the products you already use. That’s why OneSkin developed PREP: a gentle daily cleanser for all skin types that’s scientifically proven to optimize the effectiveness of OS-01 FACE.
01
What is PREP?
PREP is a gentle daily cleanser that prepares your skin to fully absorb the active ingredients in OS-01 FACE, especially our proprietary peptide, OS-01.PREP works by:
- Preparing your skin to receive the OS-01 peptide: This gentle formula removes impurities that can prevent your skin from absorbing topical treatments to ensure maximum results from the OS-01 peptide, including enhanced hydration. [1]
- Gently exfoliating without irritation: Helps skin shed dead cells to speed renewal and turnover.
- Maintaining hydration while controlling oil: Preserves skin's natural lipid barrier to help protect against water loss while preventing pore congestion.
- Soothing skin as it cleanses to support even the most sensitive skin.
01
What is PREP?
PREP is a gentle daily cleanser that prepares your skin to fully absorb the active ingredients in OS-01 FACE, especially our proprietary peptide, OS-01.PREP works by:
- Preparing your skin to receive the OS-01 peptide: This gentle formula removes impurities that can prevent your skin from absorbing topical treatments to ensure maximum results from the OS-01 peptide, including enhanced hydration. [1]
- Gently exfoliating without irritation: Helps skin shed dead cells to speed renewal and turnover.
- Maintaining hydration while controlling oil: Preserves skin's natural lipid barrier to help protect against water loss while preventing pore congestion.
- Soothing skin as it cleanses to support even the most sensitive skin.
02
The Science Behind PREP
Using PREP before OS-01 FACE doubles peptide penetration [1]By comparing the amount of the OS-01 peptide present in the dermis layer of 54-year-old donor skin after treatment with OS-01 FACE, our scientists found that the OS-01 peptide absorbs 2.2 times more effectively when skin is pre-cleansed with PREP versus not pre-cleansed. This means that using PREP prior to OS-01 FACE could more than double the peptide penetration, and with a higher peptide concentration in the deeper layers of your skin, you should experience enhanced effects from using OS-01 FACE.
02
The Science Behind PREP
Using PREP before OS-01 FACE doubles peptide penetration [1]By comparing the amount of the OS-01 peptide present in the dermis layer of 54-year-old donor skin after treatment with OS-01 FACE, our scientists found that the OS-01 peptide absorbs 2.2 times more effectively when skin is pre-cleansed with PREP versus not pre-cleansed. This means that using PREP prior to OS-01 FACE could more than double the peptide penetration, and with a higher peptide concentration in the deeper layers of your skin, you should experience enhanced effects from using OS-01 FACE.
Shown in lab studies on ex vivo human skin samples (54 yr) by comparing the amount of OS-01 peptide present in the dermis layer before and after treatment with PREP + OS-01 FACE vs OS-01 FACE alone. Data measured in triplicate.
Shown in lab studies on ex vivo human skin samples (54 yr) by comparing the amount of OS-01 peptide present in the dermis layer before and after treatment with PREP + OS-01 FACE vs OS-01 FACE alone. Data measured in triplicate.
Using PREP is scientifically proven to increase the hydration effects of OS-01 FACE [1]By measuring the activity of a key biomarker associated with skin hydration (AQP3) before and after treatment in 46-year-old ex vivo skin, our scientists found that using PREP in combination with OS-01 FACE improved AQP3 activity by 40%, versus using OS-01 FACE alone. This means that by using PREP before OS-01 FACE, your skin is even better equipped to maintain optimal hydration than when using OS-01 FACE alone.
Using PREP is scientifically proven to increase the hydration effects of OS-01 FACE [1]By measuring the activity of a key biomarker associated with skin hydration (AQP3) before and after treatment in 46-year-old ex vivo skin, our scientists found that using PREP in combination with OS-01 FACE improved AQP3 activity by 40%, versus using OS-01 FACE alone. This means that by using PREP before OS-01 FACE, your skin is even better equipped to maintain optimal hydration than when using OS-01 FACE alone.
Shown in lab studies on ex vivo human skin samples (46 yr) by comparing levels of key skin hydration biomarker (AQP3) before and after treatment with PREP + OS-01 FACE vs OS-01 FACE alone. Data measured in triplicate.
Shown in lab studies on ex vivo human skin samples (46 yr) by comparing levels of key skin hydration biomarker (AQP3) before and after treatment with PREP + OS-01 FACE vs OS-01 FACE alone. Data measured in triplicate.
How do we measure penetration?
You may be wondering how it’s possible to measure penetration of the OS-01 peptide in skin. Here’s a peek into how our scientists do it:Our scientists took pieces of ex vivo donor skin and treated each sample with either: PREP and OS-01 FACE, or OS-01 FACE alone. The samples were placed in a Franz Cell, a scientific system designed to mimic the penetration of actives in skin, and then incubated overnight. The layers of the skin were then separated and the peptide concentration in the dermis (lower layer) was analyzed using mass spectrometry.
How do we measure penetration?
You may be wondering how it’s possible to measure penetration of the OS-01 peptide in skin. Here’s a peek into how our scientists do it:Our scientists took pieces of ex vivo donor skin and treated each sample with either: PREP and OS-01 FACE, or OS-01 FACE alone. The samples were placed in a Franz Cell, a scientific system designed to mimic the penetration of actives in skin, and then incubated overnight. The layers of the skin were then separated and the peptide concentration in the dermis (lower layer) was analyzed using mass spectrometry.
The results showed that the concentration of peptide found in the dermis was 2.2x higher in the sample that had been primed with PREP compared to the sample without.
The results showed that the concentration of peptide found in the dermis was 2.2x higher in the sample that had been primed with PREP compared to the sample without.
02
Why penetration matters
While many topical skin products contain beneficial ingredients, you may never see results if those ingredients don’t enter the deeper layers of skin. Unfortunately, testing the penetration of key ingredients within formulations isn’t something that most skin care companies do. So while you could be buying products with all of the right ingredients, they might just be sitting on top of your skin rather than actually transforming it.Because penetration is half the battle when it comes to topical product efficacy, OneSkin has made penetration testing a core step in our R&D process, informing our choices when it comes to peptide concentration, raw material selection, and formulation development.
02
Why penetration matters
While many topical skin products contain beneficial ingredients, you may never see results if those ingredients don’t enter the deeper layers of skin. Unfortunately, testing the penetration of key ingredients within formulations isn’t something that most skin care companies do. So while you could be buying products with all of the right ingredients, they might just be sitting on top of your skin rather than actually transforming it.Because penetration is half the battle when it comes to topical product efficacy, OneSkin has made penetration testing a core step in our R&D process, informing our choices when it comes to peptide concentration, raw material selection, and formulation development.
03
What results will PREP enhance?
OS-01 FACE is powered by the OS-01 peptide, which was developed by OneSkin’s team of scientists to reverse skin aging at the cellular level. The OS-01 peptide has been scientifically proven to both reduce the burden of senescent cells in the skin and stimulate the renewal of new skin cells. [1,2] It also activates key biomarkers associated with collagen and hyaluronic acid production while reducing the activity of aging and inflammation biomarkers. [1,2] In a 12-week clinical study evaluating the efficacy of OS-01 FACE, participants experienced improvements in skin barrier function, wrinkles, fine lines, and elasticity. [1,3] Because PREP increases the concentration of the OS-01 peptide in skin, more pronounced results would be expected from use of both. Stay tuned! Our scientists plan on collecting even more data on these enhanced effects in the future.
03
What results will PREP enhance?
OS-01 FACE is powered by the OS-01 peptide, which was developed by OneSkin’s team of scientists to reverse skin aging at the cellular level. The OS-01 peptide has been scientifically proven to both reduce the burden of senescent cells in the skin and stimulate the renewal of new skin cells. [1,2] It also activates key biomarkers associated with collagen and hyaluronic acid production while reducing the activity of aging and inflammation biomarkers. [1,2] In a 12-week clinical study evaluating the efficacy of OS-01 FACE, participants experienced improvements in skin barrier function, wrinkles, fine lines, and elasticity. [1,3] Because PREP increases the concentration of the OS-01 peptide in skin, more pronounced results would be expected from use of both. Stay tuned! Our scientists plan on collecting even more data on these enhanced effects in the future.
Related Products
Related Products
Key Takeaways:
- PREP is a gentle cleanser that removes impurities and uses gentle exfoliation to cleanse the skin.
- PREP prepares the skin to receive topical ingredients into the deeper layers of the skin.
- Studies have shown that using PREP before OS-01 FACE doubles the OS-01 peptide penetration [1], likely increasing the effectiveness of OS-01 FACE.
- Studies have shown that using PREP in combination with OS-01 FACE improved AQP3 (a key biomarker associated with skin hydration) activity by 40%, versus using OS-01 FACE alone. [1]
Key Takeaways:
- PREP is a gentle cleanser that removes impurities and uses gentle exfoliation to cleanse the skin.
- PREP prepares the skin to receive topical ingredients into the deeper layers of the skin.
- Studies have shown that using PREP before OS-01 FACE doubles the OS-01 peptide penetration [1], likely increasing the effectiveness of OS-01 FACE.
- Studies have shown that using PREP in combination with OS-01 FACE improved AQP3 (a key biomarker associated with skin hydration) activity by 40%, versus using OS-01 FACE alone. [1]
References
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16242
References
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16242
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
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Do You Know What Clinical Claims Really Mean?
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2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
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Symptoms and Causes of Melasma on Face
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A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
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Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging