How To Reduce Hyperpigmentation by Targeting Cellular Senescence
7 min read
May 02,2023
SKIN SCIENCE, ONESKIN PRODUCTS
How To Reduce Hyperpigmentation by Targeting Cellular Senescence
7 min read
May 02,2023
SKIN SCIENCE, ONESKIN PRODUCTS
Suddenly seeing sun spots on your skin? This is a telltale sign of hyperpigmentation, a common skin condition caused by the overproduction of melanin, the pigment that gives color to your skin, hair, and eyes. Regardless of your skin tone, hyperpigmentation can pop up as you get older and be incredibly difficult to treat.For decades, the skin care industry has focused on exfoliating ingredients and harsh resurfacing treatments to help brighten the appearance of hyperpigmentation. But is this really the right approach? Let’s take a closer look at the science behind hyperpigmentation– and why addressing the root cause of excess skin pigment may be a smarter solution to sun spots.
Suddenly seeing sun spots on your skin? This is a telltale sign of hyperpigmentation, a common skin condition caused by the overproduction of melanin, the pigment that gives color to your skin, hair, and eyes. Regardless of your skin tone, hyperpigmentation can pop up as you get older and be incredibly difficult to treat.For decades, the skin care industry has focused on exfoliating ingredients and harsh resurfacing treatments to help brighten the appearance of hyperpigmentation. But is this really the right approach? Let’s take a closer look at the science behind hyperpigmentation– and why addressing the root cause of excess skin pigment may be a smarter solution to sun spots.
01
What is skin hyperpigmentation?
Hyperpigmentation is a common skin condition that results in the darkening of patches of skin. It can look different on different people– from small dark spots to large patches of darkened skin.
01
What is skin hyperpigmentation?
Hyperpigmentation is a common skin condition that results in the darkening of patches of skin. It can look different on different people– from small dark spots to large patches of darkened skin.
02
What causes hyperpigmentation?
Melanin is the overarching term for a group of pigments that occur in human hair, skin, and eyes. The darker your skin tone or hair, the more melanin your body produces. Melanin is made by special cells called melanocytes, which produce and transfer melanin pigments to neighboring cells.(1)Hyperpigmentation occurs when our melanocytes go into overdrive, producing lots and lots of melanin that collects in the skin. While scientists believe that the body creates melanin as a protective measure against sun damage, the exact biological purpose of overactive melanin production is still not entirely clear.(1) Part of the mystery is that while the majority of hyperpigmentation occurs due to unprotected sun exposure, not all hyperpigmentation is related to UV rays.Hormonal shifts caused by pregnancy, menopause or certain medications can also cause hyperpigmentation. The reason skin creates more melanin in response to these hormonal shifts isn’t fully known.Additionally, inflammatory skin conditions like acne and eczema can cause injury to the skin that then triggers the skin to produce more melanin. This is called post-inflammatory hyperpigmentation or PIH.(2)
02
What causes hyperpigmentation?
Melanin is the overarching term for a group of pigments that occur in human hair, skin, and eyes. The darker your skin tone or hair, the more melanin your body produces. Melanin is made by special cells called melanocytes, which produce and transfer melanin pigments to neighboring cells.(1)Hyperpigmentation occurs when our melanocytes go into overdrive, producing lots and lots of melanin that collects in the skin. While scientists believe that the body creates melanin as a protective measure against sun damage, the exact biological purpose of overactive melanin production is still not entirely clear.(1) Part of the mystery is that while the majority of hyperpigmentation occurs due to unprotected sun exposure, not all hyperpigmentation is related to UV rays.Hormonal shifts caused by pregnancy, menopause or certain medications can also cause hyperpigmentation. The reason skin creates more melanin in response to these hormonal shifts isn’t fully known.Additionally, inflammatory skin conditions like acne and eczema can cause injury to the skin that then triggers the skin to produce more melanin. This is called post-inflammatory hyperpigmentation or PIH.(2)
03
Why do we see more hyperpigmentation as we age?
As we age, our skin becomes less efficient at producing and evenly distributing melanin throughout the skin. At the center of this phenomenon is cellular senescence, the accumulation of cells at the end of their life cycle that induce aging in neighboring cells. Senescent cells come in all forms – including senescent melanocytes. As these cells accumulate in aged skin, they contribute to accelerated, age-associated hyperpigmentation.(3)
03
Why do we see more hyperpigmentation as we age?
As we age, our skin becomes less efficient at producing and evenly distributing melanin throughout the skin. At the center of this phenomenon is cellular senescence, the accumulation of cells at the end of their life cycle that induce aging in neighboring cells. Senescent cells come in all forms – including senescent melanocytes. As these cells accumulate in aged skin, they contribute to accelerated, age-associated hyperpigmentation.(3)
04
What are common treatments for hyperpigmentation?
Hyperpigmentation leaves many of us scrambling for the beauty aisle or a derm appointment looking for a solution. For many years, most of the available solutions have included harsh exfoliants, which help brighten hyperpigmentation by bringing excess melanin to the surface of the skin where it is sloughed away. Common solutions include:
- Chemical peels: A chemical peel involves applying a chemical solution to the skin to remove the top layer of dead skin cells. This can help reduce the appearance of hyperpigmentation by shedding melanin-rich skin at the surface of the skin and bringing deeper melanin deposits to the surface. Whether at-home or in-office, most chemical peels are mild and result in only temporary redness, dryness and peeling. For deep hyperpigmentation, dermatologists may recommend intensive in-office peels that require a longer period of healing and more painful side effects.
- Laser therapy: Laser therapy uses high-energy light to target and break up the pigmented cells in the skin, which are then absorbed by the body's immune system. Depending on the type of laser used, side effects may include a mild, sunburned sensation to more pronounced pain and redness for a period of days. Some lasers are not recommended for deeper skin tones and may actually trigger further hyperpigmentation, so it’s important to find a skilled practitioner for your skin tone.
- Microdermabrasion: This treatment involves using a device to exfoliate the top layer of skin. Like other forms of exfoliation, repeated treatments can help reduce the appearance of hyperpigmentation. Side effects include temporary redness and irritation. As with laser treatments, it’s important to find a skilled practitioner to avoid causing skin injury that can actually increase melanin production.
- Topical creams: Over-the-counter or prescription creams containing hydroquinone, kojic acid, or retinoids are commonly used to help reduce the appearance of hyperpigmentation. Unfortunately, many of these active ingredients come with difficult downsides. Hydroquinone, in particular, while very effective at reducing hyperpigmentation, can cause irritation and a side effect called ochronosis, which results in blue-black or gray-blue discoloration.(4) Similarly, kojic acid and retinol treatments may be difficult to tolerate for people with sensitive or dry skin–triggering redness, irritation, and skin peeling.
04
What are common treatments for hyperpigmentation?
Hyperpigmentation leaves many of us scrambling for the beauty aisle or a derm appointment looking for a solution. For many years, most of the available solutions have included harsh exfoliants, which help brighten hyperpigmentation by bringing excess melanin to the surface of the skin where it is sloughed away. Common solutions include:
- Chemical peels: A chemical peel involves applying a chemical solution to the skin to remove the top layer of dead skin cells. This can help reduce the appearance of hyperpigmentation by shedding melanin-rich skin at the surface of the skin and bringing deeper melanin deposits to the surface. Whether at-home or in-office, most chemical peels are mild and result in only temporary redness, dryness and peeling. For deep hyperpigmentation, dermatologists may recommend intensive in-office peels that require a longer period of healing and more painful side effects.
- Laser therapy: Laser therapy uses high-energy light to target and break up the pigmented cells in the skin, which are then absorbed by the body's immune system. Depending on the type of laser used, side effects may include a mild, sunburned sensation to more pronounced pain and redness for a period of days. Some lasers are not recommended for deeper skin tones and may actually trigger further hyperpigmentation, so it’s important to find a skilled practitioner for your skin tone.
- Microdermabrasion: This treatment involves using a device to exfoliate the top layer of skin. Like other forms of exfoliation, repeated treatments can help reduce the appearance of hyperpigmentation. Side effects include temporary redness and irritation. As with laser treatments, it’s important to find a skilled practitioner to avoid causing skin injury that can actually increase melanin production.
- Topical creams: Over-the-counter or prescription creams containing hydroquinone, kojic acid, or retinoids are commonly used to help reduce the appearance of hyperpigmentation. Unfortunately, many of these active ingredients come with difficult downsides. Hydroquinone, in particular, while very effective at reducing hyperpigmentation, can cause irritation and a side effect called ochronosis, which results in blue-black or gray-blue discoloration.(4) Similarly, kojic acid and retinol treatments may be difficult to tolerate for people with sensitive or dry skin–triggering redness, irritation, and skin peeling.
05
The OS-01 peptide may address hyperpigmentation better than common topical alternatives
Given the downsides of topical hyperpigmentation treatments, our scientists decided to test if our proprietary OS-01 peptide could outperform kojic acid and retinoic acid (retinol) in the lab.Because the OS-01 peptide has been scientifically proven to reduce cellular senescence (5) -- a root cause of hyperpigmentation -- our scientists hypothesized that it would actually reduce source of hyperpigmentation more effectively than topical treatments that only treat surface-level symptoms.The study was performed in three steps:
- Induce hyperpigmentation: To induce melanin production in human skin cells in vitro, our scientists exposed melanocytes to IBMX (isobutylmethylxanthine), a molecule that mimics one of the main pathways induced by UV radiation and also imitates a pathway induced by ACTH (adrenocorticotropic hormone), a hormone that is thought to be one of the main factors behind melasma.
- Expose melanocytes to different treatments: After the melanocytes were exposed to IBMX to induce melanin production, we treated the melanocytes with either nothing (positive control), retinoic acid, kojic acid, or the OS-01 peptide.
- Measure resulting melanin production: Finally, we measured the amount of melanin production both intracellularly (inside the cells) and extracellularly (outside of the cells).
05
The OS-01 peptide may address hyperpigmentation better than common topical alternatives
Given the downsides of topical hyperpigmentation treatments, our scientists decided to test if our proprietary OS-01 peptide could outperform kojic acid and retinoic acid (retinol) in the lab.Because the OS-01 peptide has been scientifically proven to reduce cellular senescence (5) -- a root cause of hyperpigmentation -- our scientists hypothesized that it would actually reduce source of hyperpigmentation more effectively than topical treatments that only treat surface-level symptoms.The study was performed in three steps:
- Induce hyperpigmentation: To induce melanin production in human skin cells in vitro, our scientists exposed melanocytes to IBMX (isobutylmethylxanthine), a molecule that mimics one of the main pathways induced by UV radiation and also imitates a pathway induced by ACTH (adrenocorticotropic hormone), a hormone that is thought to be one of the main factors behind melasma.
- Expose melanocytes to different treatments: After the melanocytes were exposed to IBMX to induce melanin production, we treated the melanocytes with either nothing (positive control), retinoic acid, kojic acid, or the OS-01 peptide.
- Measure resulting melanin production: Finally, we measured the amount of melanin production both intracellularly (inside the cells) and extracellularly (outside of the cells).
Shown in skin cells (melanocytes) in vitro , comparing the effects of the OS-01 peptide to retinoic acid and kojic acid on intracellular and extracellular melanin production.
The results of our study were astounding. While all three treatments reduced melanin production, the OS-01 peptide reduced melanin production significantly more – demonstrating its potential superiority in reducing skin hyperpigmentation.Not only can the OS-01 peptide address melanin production more effectively, it can also do so without the irritating side effects commonly seen with retinoic acid and kojic acid. In fact, the OS-01 peptide has been shown to greatly improve skin health markers by increasing skin’s epidermal thickness, improving skin’s barrier function, and increasing key biomarkers associated with production of collagen and hyaluronic acid. (5) This data indicates that the OS-01 peptide could be a superior topical method for supporting an even skin tone and long-term skin health.
Shown in skin cells (melanocytes) in vitro , comparing the effects of the OS-01 peptide to retinoic acid and kojic acid on intracellular and extracellular melanin production.
The results of our study were astounding. While all three treatments reduced melanin production, the OS-01 peptide reduced melanin production significantly more – demonstrating its potential superiority in reducing skin hyperpigmentation.Not only can the OS-01 peptide address melanin production more effectively, it can also do so without the irritating side effects commonly seen with retinoic acid and kojic acid. In fact, the OS-01 peptide has been shown to greatly improve skin health markers by increasing skin’s epidermal thickness, improving skin’s barrier function, and increasing key biomarkers associated with production of collagen and hyaluronic acid. (5) This data indicates that the OS-01 peptide could be a superior topical method for supporting an even skin tone and long-term skin health.
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Key Takeaways:
- Hyperpigmentation is an age-related condition in which excess melanin collects in deposits around the skin.
- While hyperpigmentation can be triggered by UV exposure or hormones, it commonly appears later in life as a result of increased cellular senescence.
- Common topical treatments like kojic acid, retinol, and hydroquinone have risks including irritation, skin aging and skin discoloration or darkening.
- In a study comparing retinoic acid, kojic acid, and OneSkin’s OS-01 peptide, OS-01 notably outperformed all other treatments in its ability to reduce melanin content in skin (shown in lab studies on human skin samples).
- This result may be due in part to the OS-01 peptide’s proven ability to reduce cellular senescence, as shown in lab studies on ex vivo human skin samples. (3)
Key Takeaways:
- Hyperpigmentation is an age-related condition in which excess melanin collects in deposits around the skin.
- While hyperpigmentation can be triggered by UV exposure or hormones, it commonly appears later in life as a result of increased cellular senescence.
- Common topical treatments like kojic acid, retinol, and hydroquinone have risks including irritation, skin aging and skin discoloration or darkening.
- In a study comparing retinoic acid, kojic acid, and OneSkin’s OS-01 peptide, OS-01 notably outperformed all other treatments in its ability to reduce melanin content in skin (shown in lab studies on human skin samples).
- This result may be due in part to the OS-01 peptide’s proven ability to reduce cellular senescence, as shown in lab studies on ex vivo human skin samples. (3)
References
- WebMD https://www.webmd.com/a-to-z-guides/what-is-melanin
- Healthline https://www.healthline.com/health/hyperpigmentation#types
- ScienceDirect https://www.sciencedirect.com/science/article/pii/S0047637420301184
- NCBI https://www.ncbi.nim.nih.gov/books/NBK539693/
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
References
- WebMD https://www.webmd.com/a-to-z-guides/what-is-melanin
- Healthline https://www.healthline.com/health/hyperpigmentation#types
- ScienceDirect https://www.sciencedirect.com/science/article/pii/S0047637420301184
- NCBI https://www.ncbi.nim.nih.gov/books/NBK539693/
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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OS-01 BODY SPF and OS-01 BODY: Even Better Togethe...
Introducing OS-01 BODY SPF: Triple power protectio...
Is Talc Bad for Skin? 7 Things You Need to Know
How Do We Know the OS-01 Peptide is Safe?
What Is Lanolin and Is It Bad for Your Skin?
Non-Comedogenic vs Comedogenic Skin Care Products
Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
Petrolatum: Is it Safe or Harmful for Your Skin?
How Much Sunscreen to Apply
What Do Antioxidants Do For Skin and Why Should Yo...
Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging