Take an Inside Look into Our Cutting-Edge R&D Platform
6 min read
JULY 07, 2022
July 07,2022
FROM THE ONESKIN LAB
Take an Inside Look into Our Cutting-Edge R&D Platform
6 min read
JULY 07, 2022
July 07,2022
FROM THE ONESKIN LAB
At OneSkin, we transform the way humans experience aging through the power of longevity science. This science is how we discovered OS-01, the first peptide proven to skin reverse aging on the cellular level. (1) This powerful molecule aids in cellular repair, blocking the spread of cellular senescence and allowing your skin to look, feel, and behave like younger skin. (1) This results in boosted collagen biosynthesis, increased in epidermal thickness, and improved skin barrier function. (1)
At OneSkin, we transform the way humans experience aging through the power of longevity science. This science is how we discovered OS-01, the first peptide proven to skin reverse aging on the cellular level. (1) This powerful molecule aids in cellular repair, blocking the spread of cellular senescence and allowing your skin to look, feel, and behave like younger skin. (1) This results in boosted collagen biosynthesis, increased in epidermal thickness, and improved skin barrier function. (1)
01
OUR APPROACH IS DIFFERENT
Most skincare companies are led by marketing teams that outsource their research to external labs. OneSkin is different. We’re led by scientists who run our end-to-end R&D process in-house and strictly adhere to the scientific process. The result? Research first. Products second. Data-validated claims always.
01
OUR APPROACH IS DIFFERENT
Most skincare companies are led by marketing teams that outsource their research to external labs. OneSkin is different. We’re led by scientists who run our end-to-end R&D process in-house and strictly adhere to the scientific process. The result? Research first. Products second. Data-validated claims always.
02
OUR R&D PLATFORM
Our R&D platform was designed to reliably and accurately measure the efficacy of skin aging interventions at the molecular level. Developed by our founding team of four female PhDs, our rigorous scientific methodology is applied throughout all phases of product development to ensure that our products meet the highest standards of scientific validation.Our platform also makes it possible to compare our products against other leading ingredients to ensure that we’re creating the new gold standard in "anti-aging" products. This data allows us to identify the most effective treatments and effectively remove the guesswork from skin care.
02
OUR R&D PLATFORM
Our R&D platform was designed to reliably and accurately measure the efficacy of skin aging interventions at the molecular level. Developed by our founding team of four female PhDs, our rigorous scientific methodology is applied throughout all phases of product development to ensure that our products meet the highest standards of scientific validation.Our platform also makes it possible to compare our products against other leading ingredients to ensure that we’re creating the new gold standard in "anti-aging" products. This data allows us to identify the most effective treatments and effectively remove the guesswork from skin care.
03
HOW WE VALIDATE OUR CLAIMS
At the center of our R&D platform sit two proprietary biomedical methods: MolClock and Skin Age Modeling. We also use beta galactosidase staining and gene expression analyses for several senescence-related markers to quantify the level of cellular senescence in skin.
- MolClock: The first molecular clock to measure skin’s biological age. (2)
- Skin Age Modeling: How we replicate skin aging and analyze product efficacy on 3D lab-grown human skin models and ex vivo human skin samples.
- Beta-Galactosidase Staining: How we measure cellular senescence in skin cells.
03
HOW WE VALIDATE OUR CLAIMS
At the center of our R&D platform sit two proprietary biomedical methods: MolClock and Skin Age Modeling. We also use beta galactosidase staining and gene expression analyses for several senescence-related markers to quantify the level of cellular senescence in skin.
- MolClock: The first molecular clock to measure skin’s biological age. (2)
- Skin Age Modeling: How we replicate skin aging and analyze product efficacy on 3D lab-grown human skin models and ex vivo human skin samples.
- Beta-Galactosidase Staining: How we measure cellular senescence in skin cells.
04
A CLOSER LOOK AT MOLCLOCK
MolClock is the first molecular clock that measures your skin’s biological age. (2) Developed by OneSkin co-founder Mariana Boroni, PhD, MolClock measures an important molecular biomarker called DNA methylation. As we age, our DNA experiences predictable and linear changes. One such change, called DNA methylation, occurs when methyl groups bind to our DNA. By analyzing the extent of DNA methylation, we can determine the skin’s biological age.The MolClock algorithm was trained using data from over 500 human skin samples and over 2,000 DNA methylation (DNAm) markers. (2) This expansive body of genetic data makes MolClock an incredibly accurate predictor of skin’s biological age.
04
A CLOSER LOOK AT MOLCLOCK
MolClock is the first molecular clock that measures your skin’s biological age. (2) Developed by OneSkin co-founder Mariana Boroni, PhD, MolClock measures an important molecular biomarker called DNA methylation. As we age, our DNA experiences predictable and linear changes. One such change, called DNA methylation, occurs when methyl groups bind to our DNA. By analyzing the extent of DNA methylation, we can determine the skin’s biological age.The MolClock algorithm was trained using data from over 500 human skin samples and over 2,000 DNA methylation (DNAm) markers. (2) This expansive body of genetic data makes MolClock an incredibly accurate predictor of skin’s biological age.
Figure 1. Methylation is an epigenetic modification that occurs with age.
MolClock also makes it possible for us to quantify the age-reversal capabilities of topical skin treatments like our proprietary peptide, OS-01. By using MolClock to determine the skin’s biological age before and after topical treatment, we can quantify just how much an ingredient reverses or accelerates skin aging.
Figure 1. Methylation is an epigenetic modification that occurs with age.
MolClock also makes it possible for us to quantify the age-reversal capabilities of topical skin treatments like our proprietary peptide, OS-01. By using MolClock to determine the skin’s biological age before and after topical treatment, we can quantify just how much an ingredient reverses or accelerates skin aging.
05
UNDERSTANDING SKIN AGE MODELING
To further analyze the effects of topical treatments on skin aging, we use 3D lab-grown human skin models and ex vivo human skin samples to measure both molecular and structural skin changes. Here’s a step-by-step look at how it works:STEP 1: GROW THE SKINEvery week in the OneSkin Lab, we grow 3D skin models in vitro using skin cells—fibroblasts and keratinocytes—obtained from post-op patients of various ages and ethnicities. Our lab-grown skin models are remarkably similar to skin on your body, with two distinct layers (epidermis and dermis), each displaying cellular structure and morphology almost identical to your skin.By growing skin models from donors of different ages, we are able to analyze the biological, genetic, and morphological differences between them, effectively creating snapshots in time of the human skin aging process.
05
UNDERSTANDING SKIN AGE MODELING
To further analyze the effects of topical treatments on skin aging, we use 3D lab-grown human skin models and ex vivo human skin samples to measure both molecular and structural skin changes. Here’s a step-by-step look at how it works:STEP 1: GROW THE SKINEvery week in the OneSkin Lab, we grow 3D skin models in vitro using skin cells—fibroblasts and keratinocytes—obtained from post-op patients of various ages and ethnicities. Our lab-grown skin models are remarkably similar to skin on your body, with two distinct layers (epidermis and dermis), each displaying cellular structure and morphology almost identical to your skin.By growing skin models from donors of different ages, we are able to analyze the biological, genetic, and morphological differences between them, effectively creating snapshots in time of the human skin aging process.
Figure 2. Image of 3D human skin models grown in the OneSkin lab.
Figure 2. Image of 3D human skin models grown in the OneSkin lab.
Figure 3. Histology images of 3D human skin models grown in the OneSkin lab vs real skin (viewed under the microscope).
Figure 3. Histology images of 3D human skin models grown in the OneSkin lab vs real skin (viewed under the microscope).
Figure 4. Histology images of 3D human skin models from donors of different ages. Human 3D skin equivalents built with cells derived from older donors present aging features, including thinner epidermis and aging markers.
Figure 4. Histology images of 3D human skin models from donors of different ages. Human 3D skin equivalents built with cells derived from older donors present aging features, including thinner epidermis and aging markers.
STEP 2: TREAT THE SKINAfter growing the skin in the lab, we apply topical products to the skin models and measure their effects at the molecular and structural levels (steps 3 & 4). This is the part of the process that allows us to validate OS-01’s efficacy and compare it to other ingredients on the market.STEP 3: ANALYZE GENE EXPRESSIONWe extract the RNA from the skin models and analyze the expression of up to 20 different genes in the dermis and epidermis. Through this process, we can see which genes have been activated and which have been suppressed by treatment. The goal: activate genes related to healthier skin, such as those that promote collagen, hyaluronic acid, and keratins, and suppress the activity of genes related to aging and skin deterioration, such as inflammatory cytokines, IL-6, IL-8, and MMP-1.STEP 4: EXAMINE SKIN STRUCTUREUsing an imaging process called histology, we analyze sections of the skin under a microscope to examine the skin structure. A good product will promote epidermal thickness and improve skin cell organization so that it looks similar to young skin under the microscope.
STEP 2: TREAT THE SKINAfter growing the skin in the lab, we apply topical products to the skin models and measure their effects at the molecular and structural levels (steps 3 & 4). This is the part of the process that allows us to validate OS-01’s efficacy and compare it to other ingredients on the market.STEP 3: ANALYZE GENE EXPRESSIONWe extract the RNA from the skin models and analyze the expression of up to 20 different genes in the dermis and epidermis. Through this process, we can see which genes have been activated and which have been suppressed by treatment. The goal: activate genes related to healthier skin, such as those that promote collagen, hyaluronic acid, and keratins, and suppress the activity of genes related to aging and skin deterioration, such as inflammatory cytokines, IL-6, IL-8, and MMP-1.STEP 4: EXAMINE SKIN STRUCTUREUsing an imaging process called histology, we analyze sections of the skin under a microscope to examine the skin structure. A good product will promote epidermal thickness and improve skin cell organization so that it looks similar to young skin under the microscope.
Figure 5. Histology images of 3D skin equivalents exposed to nothing (no treatment), the OS-01 peptide, and other products on the market (Product A and Product B)
Figure 5. Histology images of 3D skin equivalents exposed to nothing (no treatment), the OS-01 peptide, and other products on the market (Product A and Product B)
STEP 5: DETERMINE SKIN SCORENext, we apply a grading system called Skin Score. Based on the expression of 20 different genes in both the dermis and epidermis, along with morphological changes seen under the microscope, the skin score helps our scientists assess the overall efficacy of topical products.Using Skin Age Modeling and MolColck, we have shown that the OS-01 peptide prevents the accumulation of aging markers, supports cellular repair, and reduces skin’s biological age. (1)
STEP 5: DETERMINE SKIN SCORENext, we apply a grading system called Skin Score. Based on the expression of 20 different genes in both the dermis and epidermis, along with morphological changes seen under the microscope, the skin score helps our scientists assess the overall efficacy of topical products.Using Skin Age Modeling and MolColck, we have shown that the OS-01 peptide prevents the accumulation of aging markers, supports cellular repair, and reduces skin’s biological age. (1)
06
MEASURING CELLULAR SENESCENCE USING BETA-GALACTOSIDASE AND GENE EXPRESSION ANALYSES
When compared to healthy cells, senescent cells show high activity of an enzyme called beta galactosidase. By applying this enzyme’s substrate, called X-gal, to skin cells, senescent cells are stained blue. This makes it possible to identify and count the number of senescent cells in skin. We also utilize gene expression analyses for several senescence-related markers to measure the level of cellular senescence in skin. By comparing the number of senescent cells before and after topical treatment, we can quantify the treatment’s ability to reduce cellular senescence.In our studies, the OS-01 peptide reduces the number of senescent cells in skin by up to 50% while maintaining the total number of cells, meaning it promoted not just the reduction of senescent cells, but also the renewal of healthier ones. (1)
06
MEASURING CELLULAR SENESCENCE USING BETA-GALACTOSIDASE AND GENE EXPRESSION ANALYSES
When compared to healthy cells, senescent cells show high activity of an enzyme called beta galactosidase. By applying this enzyme’s substrate, called X-gal, to skin cells, senescent cells are stained blue. This makes it possible to identify and count the number of senescent cells in skin. We also utilize gene expression analyses for several senescence-related markers to measure the level of cellular senescence in skin. By comparing the number of senescent cells before and after topical treatment, we can quantify the treatment’s ability to reduce cellular senescence.In our studies, the OS-01 peptide reduces the number of senescent cells in skin by up to 50% while maintaining the total number of cells, meaning it promoted not just the reduction of senescent cells, but also the renewal of healthier ones. (1)
Figure 6. Senescent cells (blue) stained using beta galactosidase in skin before (control) and after treatment with the OS-01 peptide
Figure 6. Senescent cells (blue) stained using beta galactosidase in skin before (control) and after treatment with the OS-01 peptide
07
PIONEERING A HIGHER STANDARD FOR WHAT YOU PUT ON YOUR SKIN
By utilizing biomedical approaches throughout all stages of product development, we are pioneering a new paradigm in skin longevity and defining a new standard for the products you use on your skin. Ready to join the movement? Check out our innovative line of topical supplements, powered by OS-01.WANT MORE SCIENCE?Check out our scientific publications.
07
PIONEERING A HIGHER STANDARD FOR WHAT YOU PUT ON YOUR SKIN
By utilizing biomedical approaches throughout all stages of product development, we are pioneering a new paradigm in skin longevity and defining a new standard for the products you use on your skin. Ready to join the movement? Check out our innovative line of topical supplements, powered by OS-01.WANT MORE SCIENCE?Check out our scientific publications.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging