UV Damage Increases Cellular Senescence. Here's How to Stop It.
3 min read
may 10, 2023
May 10,2023
SKIN SCIENCE
UV Damage Increases Cellular Senescence. Here's How to Stop It.
3 min read
may 10, 2023
May 10,2023
SKIN SCIENCE
There’s a reason every dermatologist’s first skincare recommendation is SPF: unprotected sun exposure causes skin cancer and is responsible for up to 90% of visible signs of aging, which means that SPF might be the best preventative aging solution that we have.But for many of us, a lot of the damage has already been done. Blame it on your tanning bed years or just the ignorance of youth: photodamage that you experience in your early years can have very real impacts on your skin health for the rest of your life, including increased rates of cellular senescence and chronic inflammation. So what can we do about the damage that’s already been done? Let’s take a closer look at how photogaging works and the promising new therapies available to help reverse its effects.
There’s a reason every dermatologist’s first skincare recommendation is SPF: unprotected sun exposure causes skin cancer and is responsible for up to 90% of visible signs of aging, which means that SPF might be the best preventative aging solution that we have.But for many of us, a lot of the damage has already been done. Blame it on your tanning bed years or just the ignorance of youth: photodamage that you experience in your early years can have very real impacts on your skin health for the rest of your life, including increased rates of cellular senescence and chronic inflammation. So what can we do about the damage that’s already been done? Let’s take a closer look at how photogaging works and the promising new therapies available to help reverse its effects.
01
UV Damage is the #1 Extrinsic Aging Factor
Let’s quickly review the two major types of aging: intrinsic aging is largely determined by your genetic profile while extrinsic aging occurs as a result of environmental exposures and daily lifestyle habits. While there are many extrinsic aging factors– air pollution and cigarette smoke just to name a couple–UV radiation is by far the most common and potent aging factor that we face in our daily lives.Like intrinsic aging, photoaging is cumulative and adds up over a lifetime. However, while intrinsic aging naturally requires the passage of time, photoaging can occur very quickly depending on the degree of sun exposure and the amount of UV-blocking pigment naturally present in your skin. This means that if you’re very fair-skinned and rarely wear sunscreen, your skin will actually age much faster than it ordinarily would without UV damage. This increases the biological age of your skin and reduces your skinspan–the amount of time your skin is healthy.
01
UV Damage is the #1 Extrinsic Aging Factor
Let’s quickly review the two major types of aging: intrinsic aging is largely determined by your genetic profile while extrinsic aging occurs as a result of environmental exposures and daily lifestyle habits. While there are many extrinsic aging factors– air pollution and cigarette smoke just to name a couple–UV radiation is by far the most common and potent aging factor that we face in our daily lives.Like intrinsic aging, photoaging is cumulative and adds up over a lifetime. However, while intrinsic aging naturally requires the passage of time, photoaging can occur very quickly depending on the degree of sun exposure and the amount of UV-blocking pigment naturally present in your skin. This means that if you’re very fair-skinned and rarely wear sunscreen, your skin will actually age much faster than it ordinarily would without UV damage. This increases the biological age of your skin and reduces your skinspan–the amount of time your skin is healthy.
02
UV Damage Induces Cellular Senescence & Accelerates Aging
On the cellular level, UV exposure causes cells to prematurely enter senescence, a state in which a cell has reached the end of its lifecycle and should be cleared away, but instead lingers. A central hallmark of skin aging, cellular senescence is the accumulation of aged, zombie cells that induce aging in neighboring cells. The faster that our cells fall into senescence, the more difficult it is for the body to efficiently clear them away – precipitating a cascade of aging that can result in impaired skin regeneration, chronic inflammation, and even skin cancer. As skin is exposed to more UV radiation, this damage accelerates even further, leading to premature aging.
02
UV Damage Induces Cellular Senescence & Accelerates Aging
On the cellular level, UV exposure causes cells to prematurely enter senescence, a state in which a cell has reached the end of its lifecycle and should be cleared away, but instead lingers. A central hallmark of skin aging, cellular senescence is the accumulation of aged, zombie cells that induce aging in neighboring cells. The faster that our cells fall into senescence, the more difficult it is for the body to efficiently clear them away – precipitating a cascade of aging that can result in impaired skin regeneration, chronic inflammation, and even skin cancer. As skin is exposed to more UV radiation, this damage accelerates even further, leading to premature aging.
03
What does UV-induced Senescence Look Like?
Photoaging is associated with a number of visible symptoms, including dryness, deep wrinkles, skin laxity, slow wound healing, a higher risk of skin cancer, and leathery skin caused by thickening of the epidermis.1
Many of these symptoms occur because UV-induced senescent cells alter proteins, like collagen and elastin, which keep the skin plump and firm. Without proper function of these proteins, the skin begins to show common signs of aging like skin sagging, wrinkles, and laxity. This effect on collagen and elastin may occur because UV-induced senescent cells show high expression of MMPs, a family of enzymes that break down structural proteins in the skin.¹ Research also shows that UV-induced senescence leads to an increase in melanogenesis, the production of melanin pigment within the skin. This can cause age-related hyperpigmentation or sun spots.2
03
What does UV-induced Senescence Look Like?
Photoaging is associated with a number of visible symptoms, including dryness, deep wrinkles, skin laxity, slow wound healing, a higher risk of skin cancer, and leathery skin caused by thickening of the epidermis.1
Many of these symptoms occur because UV-induced senescent cells alter proteins, like collagen and elastin, which keep the skin plump and firm. Without proper function of these proteins, the skin begins to show common signs of aging like skin sagging, wrinkles, and laxity. This effect on collagen and elastin may occur because UV-induced senescent cells show high expression of MMPs, a family of enzymes that break down structural proteins in the skin.¹ Research also shows that UV-induced senescence leads to an increase in melanogenesis, the production of melanin pigment within the skin. This can cause age-related hyperpigmentation or sun spots.2
04
Senotherapeutics Could Be the Next Frontier in Addressing Photoaging
Regularly applying SPF is widely considered the most effective way to protect against UV radiation. While scientists don’t know for certain whether sunscreens protect against UV-induced senescence, there is overwhelming evidence that SPF shields against DNA damage and reduces the levels of MMPs within the skin.
But what about the UV-induced senescence already present in your skin from your sunbathing days? That’s where senotherapeutics can help. Specifically designed to target senescent cells within the skin, senotherapeutics like the OS-01 peptide are a promising strategy for reducing UV-induced senescence and extending skinspan.1
04
Senotherapeutics Could Be the Next Frontier in Addressing Photoaging
Regularly applying SPF is widely considered the most effective way to protect against UV radiation. While scientists don’t know for certain whether sunscreens protect against UV-induced senescence, there is overwhelming evidence that SPF shields against DNA damage and reduces the levels of MMPs within the skin.
But what about the UV-induced senescence already present in your skin from your sunbathing days? That’s where senotherapeutics can help. Specifically designed to target senescent cells within the skin, senotherapeutics like the OS-01 peptide are a promising strategy for reducing UV-induced senescence and extending skinspan.1
05
The OS-01 Peptide Protects Skin Cells from UVB-Induced Cellular Senescence
In lab studies on ex vivo
human skin cells, the OS-01 peptide has been shown to reduce the total number of senescent skin cells while maintaining the overall number of skin cells, demonstrating its potential to help reverse a key driver of aging.3 But can OS-01 actually protect skin cells from UV damage, too?
05
The OS-01 Peptide Protects Skin Cells from UVB-Induced Cellular Senescence
In lab studies on ex vivo
human skin cells, the OS-01 peptide has been shown to reduce the total number of senescent skin cells while maintaining the overall number of skin cells, demonstrating its potential to help reverse a key driver of aging.3 But can OS-01 actually protect skin cells from UV damage, too?
In vitro human dermal fibroblasts (HDFs) isolated from 30 yo donors were exposed to UVB radiation (0.1J/cm^2) then immediately treated with the OS-01 peptide (12.5uM) and stained with senescence-associated beta galactosidase (SA-Bgal). Senescence levels were analyzed by counting the number of UVB-induced senescent cells. Data normalized to control. (Zonari, et al., npj Aging, 2023)
To answer this question, our scientists exposed in vitro human skin cells to UVB radiation, then immediately treated them with the OS-01 peptide. By selectively staining the samples with an enzyme that turns senescent cells blue, our researchers were able to count the total number of UVB-induced senescent cells.
The samples that were immediately treated with the OS-01 peptide experienced 42.5% less UV-induced senescent cells than the skin that was not treated with OS-01. This data indicates that the OS-01 peptide is capable of protecting skin cells from UVB damage, one of the main extrinsic aging factors. 3
In vitro human dermal fibroblasts (HDFs) isolated from 30 yo donors were exposed to UVB radiation (0.1J/cm^2) then immediately treated with the OS-01 peptide (12.5uM) and stained with senescence-associated beta galactosidase (SA-Bgal). Senescence levels were analyzed by counting the number of UVB-induced senescent cells. Data normalized to control. (Zonari, et al., npj Aging, 2023)
To answer this question, our scientists exposed in vitro human skin cells to UVB radiation, then immediately treated them with the OS-01 peptide. By selectively staining the samples with an enzyme that turns senescent cells blue, our researchers were able to count the total number of UVB-induced senescent cells.
The samples that were immediately treated with the OS-01 peptide experienced 42.5% less UV-induced senescent cells than the skin that was not treated with OS-01. This data indicates that the OS-01 peptide is capable of protecting skin cells from UVB damage, one of the main extrinsic aging factors. 3
05
How to Support Your Skin with OS-01
Despite OS-01’s powerful protective capacity, daily SPF is still an essential step in any healthy skin regimen. To get the most from both your daily SPF and the OS-01 peptide, apply OS-01 FACE before SPF in the morning and again in the evening after you wash your face.
05
How to Support Your Skin with OS-01
Despite OS-01’s powerful protective capacity, daily SPF is still an essential step in any healthy skin regimen. To get the most from both your daily SPF and the OS-01 peptide, apply OS-01 FACE before SPF in the morning and again in the evening after you wash your face.
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Key Takeaways:
- UV damage is the number one cause of extrinsic skin aging.
- By increasing cellular senescence, UV radiation accelerates skin aging and leads to the degradation of collagen and elastin.
- While scientists believe SPF prevents UV-induced senescence, more evidence is necessary.
- Senotherapeutics like the OS-01 peptide are a promising emerging option for reducing UVB-induced senescence.
- In addition to reducing the overall number of senescent cells, the OS-01 peptide has been shown to decrease UV-induced senescence by 42.5% in human skin samples exposed to UVB radiation.
Key Takeaways:
- UV damage is the number one cause of extrinsic skin aging.
- By increasing cellular senescence, UV radiation accelerates skin aging and leads to the degradation of collagen and elastin.
- While scientists believe SPF prevents UV-induced senescence, more evidence is necessary.
- Senotherapeutics like the OS-01 peptide are a promising emerging option for reducing UVB-induced senescence.
- In addition to reducing the overall number of senescent cells, the OS-01 peptide has been shown to decrease UV-induced senescence by 42.5% in human skin samples exposed to UVB radiation.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
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A Comprehensive Guide to Understanding the Differe...
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Dry Skin 101: How To Identify This Skin Type
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Developing a Skin Care Routine for Normal Skin: 4 ...
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Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
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A Comprehensive Guide to Understanding and Managin...
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How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
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How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
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How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
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How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
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Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
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Good Genes vs. Good Habits: Which Impacts Your Lon...
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What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
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8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
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Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
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The 101 Guide To Understanding Acne-Prone Skin
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OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
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101 Guide On The Benefits Of Cleansing Your Face
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Get to Know OneSkin’s Topical Supplements:
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The Top 3 Benefits of Peptides for Skin
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How OneSkin Developed the OS-01 Peptide
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101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
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Niacinamide Vs Retinol: How Do They Compare?
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OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
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Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
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What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
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Healthspan: A New Way To Think About Aging