Why Exercise is a Game-Changer for Longevity

5 min read

Jan 19, 2024 - jennifer maples
January 19,2024
LONGEVITY

Why Exercise is a Game-Changer for Longevity

5 min read

Jan 19, 2024 - jennifer maples
January 19,2024
LONGEVITY

*This post is adapted from an original post by Aastha Jain Simes, found hereto learn more about livelongerworld, with permission from the author

*This post is adapted from an original post by Aastha Jain Simes, found hereto learn more about livelongerworld, with permission from the author
Exercise is more than a way to stay fit; it's a powerful tool for extending your lifespan. Longevity expert, Dr. Peter Attia agrees, describing exercise as “the single most important longevity drug we have.” In fact, following an exercise program that focuses on strength, muscle mass, and cardiorespiratory fitness can reduce your risk of dying from a chronic disease by five times. Let that sink in for a minute.
Exercise is more than a way to stay fit; it's a powerful tool for extending your lifespan. Longevity expert, Dr. Peter Attia agrees, describing exercise as “the single most important longevity drug we have.” In fact, following an exercise program that focuses on strength, muscle mass, and cardiorespiratory fitness can reduce your risk of dying from a chronic disease by five times. Let that sink in for a minute.
01

Benefits of Exercise

Burning calories and preventing weight gain are well-known advantages of exercising. But that’s not the only reason it’s good for you. Exercise can build muscle and increase flexibility, stability, and mobility as you age in addition to health benefits that go beyond the surface, including:
  • Brain health. Exercise boosts levels of Brain-Derived Neurotrophic Factor (BDNF), a special protein known to improve memory and learning capacity. Recent studies also suggest regular activity can reverse the signs of brain aging. [01]
  • Mood support. When you exercise, the body releases feel-good chemicals that can help reduce depression and anxiety. [02]
  • Stress reduction. Working out also releases endorphins, natural chemicals that can make you feel less stressed. Since chronic stress can lead to health problems like diabetes and cardiovascular disease, regular exercise is key to aging well. [03]
  • Mitochondrial biogenesis. Additionally, regular activity stimulates the production of new mitochondria, keeping your body’s energy factories running smoothly. This is especially important as mitochondria function typically declines with age and can lead to an increase in oxidative stress, which accelerates aging. [04]
01

Benefits of Exercise

Burning calories and preventing weight gain are well-known advantages of exercising. But that’s not the only reason it’s good for you. Exercise can build muscle and increase flexibility, stability, and mobility as you age in addition to health benefits that go beyond the surface, including:
  • Brain health. Exercise boosts levels of Brain-Derived Neurotrophic Factor (BDNF), a special protein known to improve memory and learning capacity. Recent studies also suggest regular activity can reverse the signs of brain aging. [01]
  • Mood support. When you exercise, the body releases feel-good chemicals that can help reduce depression and anxiety. [02]
  • Stress reduction. Working out also releases endorphins, natural chemicals that can make you feel less stressed. Since chronic stress can lead to health problems like diabetes and cardiovascular disease, regular exercise is key to aging well. [03]
  • Mitochondrial biogenesis. Additionally, regular activity stimulates the production of new mitochondria, keeping your body’s energy factories running smoothly. This is especially important as mitochondria function typically declines with age and can lead to an increase in oxidative stress, which accelerates aging. [04]
02

Which Types of Exercises are Best?

There are three categories of activities that offer the most bang for your (longevity) buck: High-intensity interval training, strength and resistance training, and zone 2 training.

High-Intensity Interval Training

Also known as HIIT, these short, intense bursts of activity followed by brief recovery periods. Much like OneSkin’s OS-01 peptide, HIIT is an incredibly effective way to reduce senescent (or damaged, dysfunctional) cells in the body. HIIT stimulates autophagy, a cellular cleanup process that helps prevent age-related diseases. HIIT also increases your heart rate and challenges your VO2 max, a key measure of cardiovascular fitness. By pushing these limits, HIIT can enhance your heart health and overall fitness. Improved VO2 max is associated with a lower risk of cardiovascular disease and overall mortality, making HIIT a valuable tool for boosting long-term health and wellness. [05] One type of HIIT workout is called Tabata, a quick 20-minute routine where exercises are performed for 20 seconds, followed by a 10-second rest. Below is a sample Tabata workout:
  1. 20 seconds jumping jacks + 10 seconds rest
  2. 20 seconds burpees + 10 seconds rest
  3. 20 seconds jump squats + 10 seconds rest
  4. 20 seconds mountain climbers + 10 seconds rest
Repeat this workout a few times through (resting after each set) until you reach 20 minutes.
02

Which Types of Exercises are Best?

There are three categories of activities that offer the most bang for your (longevity) buck: High-intensity interval training, strength and resistance training, and zone 2 training.

High-Intensity Interval Training

Also known as HIIT, these short, intense bursts of activity followed by brief recovery periods. Much like OneSkin’s OS-01 peptide, HIIT is an incredibly effective way to reduce senescent (or damaged, dysfunctional) cells in the body. HIIT stimulates autophagy, a cellular cleanup process that helps prevent age-related diseases. HIIT also increases your heart rate and challenges your VO2 max, a key measure of cardiovascular fitness. By pushing these limits, HIIT can enhance your heart health and overall fitness. Improved VO2 max is associated with a lower risk of cardiovascular disease and overall mortality, making HIIT a valuable tool for boosting long-term health and wellness. [05] One type of HIIT workout is called Tabata, a quick 20-minute routine where exercises are performed for 20 seconds, followed by a 10-second rest. Below is a sample Tabata workout:
  1. 20 seconds jumping jacks + 10 seconds rest
  2. 20 seconds burpees + 10 seconds rest
  3. 20 seconds jump squats + 10 seconds rest
  4. 20 seconds mountain climbers + 10 seconds rest
Repeat this workout a few times through (resting after each set) until you reach 20 minutes.

Strength and Resistance Training

Muscle mass typically starts declining in your 30s with as much as 8% of lean muscle mass lost every decade after that. [06] Preventing muscle loss (or sarcopenia) helps prevent frailty as you age, reducing the risk of injuries and fractures from falls. It also decreases the chance of developing cardiovascular disease. [07] Worried about bulking up with weights? Don’t be – that's a common myth. [08] But if you are concerned or don’t have access to dumbbells, using resistance bands or your own body weight can be just as effective for strength training. These methods are great for slowing down muscle loss as you age. Regular strength training, no matter the method, is key for maintaining muscle strength and overall health and longevity. Some of our favorite exercises include:
  • Push-ups
  • Planks
  • Squats
  • Rows

Strength and Resistance Training

Muscle mass typically starts declining in your 30s with as much as 8% of lean muscle mass lost every decade after that. [06] Preventing muscle loss (or sarcopenia) helps prevent frailty as you age, reducing the risk of injuries and fractures from falls. It also decreases the chance of developing cardiovascular disease. [07] Worried about bulking up with weights? Don’t be – that's a common myth. [08] But if you are concerned or don’t have access to dumbbells, using resistance bands or your own body weight can be just as effective for strength training. These methods are great for slowing down muscle loss as you age. Regular strength training, no matter the method, is key for maintaining muscle strength and overall health and longevity. Some of our favorite exercises include:
  • Push-ups
  • Planks
  • Squats
  • Rows

Zone 2 Training

Fat loss, endurance, and better immune function are just a few of the benefits of training in Zone 2 training. Research also suggests that it decreases systemic inflammation, which can prevent everything from cardiovascular disease to cancer. [09] But what exactly is Zone 2? Think of it as the level of activity you can do while still holding a normal conversation — like a brisk walk, a slow jog, or a steady bike ride. If you own a heart rate monitor, you’ll want to keep your heart rate at 60-70% of its maximum rate. Figure out your maximum heart rate by subtracting your age from 220. For instance, a 50-year-old’s max heart rate would be 220 minus 50, or 170 beats per minute. At a 60% exertion level, a 50-year-old would want to maintain a 102-beat-per-minute average during your Zone 2 training.

Zone 2 Training

Fat loss, endurance, and better immune function are just a few of the benefits of training in Zone 2 training. Research also suggests that it decreases systemic inflammation, which can prevent everything from cardiovascular disease to cancer. [09] But what exactly is Zone 2? Think of it as the level of activity you can do while still holding a normal conversation — like a brisk walk, a slow jog, or a steady bike ride. If you own a heart rate monitor, you’ll want to keep your heart rate at 60-70% of its maximum rate. Figure out your maximum heart rate by subtracting your age from 220. For instance, a 50-year-old’s max heart rate would be 220 minus 50, or 170 beats per minute. At a 60% exertion level, a 50-year-old would want to maintain a 102-beat-per-minute average during your Zone 2 training.

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03

Conclusion

Integrating daily exercises you enjoy is an invaluable investment in your long-term health and longevity. By incorporating HIIT, strength and resistance training, and Zone 2 training, you're not only enhancing your fitness but also protecting your brain and heart health, maintaining muscle mass, and combating age-related cellular decline.
03

Conclusion

Integrating daily exercises you enjoy is an invaluable investment in your long-term health and longevity. By incorporating HIIT, strength and resistance training, and Zone 2 training, you're not only enhancing your fitness but also protecting your brain and heart health, maintaining muscle mass, and combating age-related cellular decline.
Key Takeaways:
  • The benefits of regular exercise go beyond physical fitness and avoiding weight gain
  • Regular activity enhances brain function, protects the heart, and reduces stress, contributing to better overall health as you age
  • High-intensity interval training, strength and resistance training, and Zone 2 training are the best forms of exercise for longevity
  • Choose workouts you enjoy, including Tabata, walking, cycling, or bodyweight exercises
Key Takeaways:
  • The benefits of regular exercise go beyond physical fitness and avoiding weight gain
  • Regular activity enhances brain function, protects the heart, and reduces stress, contributing to better overall health as you age
  • High-intensity interval training, strength and resistance training, and Zone 2 training are the best forms of exercise for longevity
  • Choose workouts you enjoy, including Tabata, walking, cycling, or bodyweight exercises

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Woman applying sunscreen
Addressing the Need for Indoor Sun Protection
Sunburned skin
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
Pollution
Can Air Quality Affect Skin? Exploring the Impact ...
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Understanding the Relationship Between Sleep and U...
Woman not sleeping in bed
Exploring the Effects of Quality Sleep on Your Ski...
Gut microbiom illustration
How to Improve Gut Microbiome
Woman holding bowl of food
Exploring Caloric Restriction and Its Effects on A...
woman stretching in bed
What’s the Connection Between Quality Sleep and Lo...
Healthy foods
Unlocking the Skin Benefits of Intermittent Fastin...
woman exercising
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
The Microbiome Diet and Its Effects on Skin
cold water
Cold Exposure: Hype or Longevity Boosting?
healthy foods
Eat Better, Live Longer: Top Foods for Longevity
How Environmental Stressors Affect Skin
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
OS-01 BODY
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eyes?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
lip treatment
Lip Balm Ingredients: What to Look for and What to...
earth
Exploring Blue Zones: How Can We Optimize Our Heal...
Lips
Nurturing Your Lips: How to Keep Them Moisturized ...
Lips
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
SHIELD on arm
The Importance of Sunscreen: Why Should You Wear I...
Lip sunscreen
Lip Sunscreen: Do Lips Need SPF Protection?
heart hands
The Science of Gratitude
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Removing Sunscreen: Tips for Clean and Healthy Ski...
freckled skin
Skin Explained: Is Skin An Organ?
UV Light and Skin
UV Light and Skin: Effects and Protection Strategi...
What is Epidermis
Understanding The Epidermis: Functions, Compositio...
Diving into dermis
Diving into Dermis: Functions and Significance
Why Do We Get Wrinkles
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Back skin
Why Skin Barrier is Important
bentonite clay
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
hypodermis function
Hypodermis: Exploring Its Vital Functions
oil-dropper-background-pink-dripping-cosmetic-product
The EU is Limiting Retinol in Skincare: Here’s Eve...
face+shield
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles
How to Address Stomach Wrinkles For Smoother Skin
How to Get Rid of Wrinkly Skin on Arms
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
What is Tinted Sunscreen?
two types of face wrinkles
2 Types of Wrinkles and Tips for Treating Them
Marionette Lines
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
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The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
Thick Skin vs Thin Skin
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin
How to Strengthen Your Skin: A Guide to Thicker, H...
what-is-glycerin
An In-Depth Look at Glycerin: What is it and What ...
Glycerin Benefits for Skin
Exploring the Benefits of Glycerin for Skin Health
Difference Between Hydrating and Moisturizing
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
Skin Care Routine for Oily Skin
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
Menopause and Skin Changes
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
Perfect Skin Care Routine for Combination Skin
4 Steps to Crafting the Perfect Skin Care Routine ...
Managing Combination Skin
A Comprehensive Guide to Understanding and Managin...
Benefits Of Moringa Oil
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
Restoring Dry Skin Around The Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
Woman washing her face
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks Of Aging - One Skin Technologies
Hallmarks of Aging
What Is Sensitive Skin
What is Sensitive Skin?
How OS-01 Works on Mature Skin
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
Dry, flaky skin
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin
What is the Best Skin Care Regimen for Aging Skin?
6 Benefits of Jojoba Oil
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture Types
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
5 Common Perimenopause Skin Problems
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:

OS-

...
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Optimize Your Health
How to Use Peptides In Your Skincare Regimen to Op...
peptide illustration
Peptides vs Retinol: Is One Better For Increasing ...
body skin
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
Three Ways To Extend Your Skinspan Starting With Y...
free radicals
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Longevity
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
Skin Tightening Ingredients
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation
How to Reduce Skin Inflammation & Redness
Niacinamide
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
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Why Is Nutrient Absorption Key To Better Skin Heal...
Dr. David Sinclair
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
skin repairing foods
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
closeup portrait of a model
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barrier
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care and Longevity
Representation of the Black Community in Skin Care...
Portrait of OneSkin Founders
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Health Is The New Wealth - One Skin Technologies
Health Is The New Wealth
Sleep: Nature’s Restart Button? - One Skin Technologies
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging - One Skin Technologies
Healthspan: A New Way To Think About Aging