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THE BREAKTHROUGH SCIENCE
POWERED BY THE OS-01 SENESCENCE BLOCKING PEPTIDE TM
The only peptide scientifically proven to reverse skin aging at the molecular level 01
Switches off senescent cells associated with aging to help skin behave like its younger self 02
Boosts biomarkers of healthy skin, including collagen and hyaluronic acid biosynthesis 03
Supports activation of cellular repair pathways 03
THE BREAKTHROUGH SCIENCE
POWERED BY THE OS-01 SENESCENCE BLOCKING PEPTIDE TM
The only peptide scientifically proven to reverse skin aging at the molecular level 01
Switches off senescent cells associated with aging to help skin behave like its younger self 02
Boosts biomarkers of healthy skin, including collagen and hyaluronic acid biosynthesis 03
Supports activation of cellular repair pathways 03
The Details
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The Details
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Results That Go Beyond the Lab
- 95.5% of participants saw improved skin evenness, radiance, pores and firmness*
- 87% of participants saw a reduction in the appearance of fine lines & wrinkles*
- 100% of participants saw improved skin smoothness and overall appearance*
- Participants skin’s barrier function improved by an average of + 15%*
*Shown in a 12-week clinical study performed by a third party research organization with 22 participants (OneSkin manuscript in process of publication)
- 95.5% of participants saw improved skin evenness, radiance, pores and firmness*
- 87% of participants saw a reduction in the appearance of fine lines & wrinkles*
- 100% of participants saw improved skin smoothness and overall appearance*
- Participants skin’s barrier function improved by an average of + 15%*
*Shown in a 12-week clinical study performed by a third party research organization with 22 participants (OneSkin manuscript in process of publication)
Results That Go Beyond the Lab
- 95.5% of participants saw improved skin evenness, radiance, pores and firmness*
- 87% of participants saw a reduction in the appearance of fine lines & wrinkles*
- 100% of participants saw improved skin smoothness and overall appearance*
- Participants skin’s barrier function improved by an average of + 15%*
*Shown in a 12-week clinical study performed by a third party research organization with 22 participants (OneSkin manuscript in process of publication)
- 95.5% of participants saw improved skin evenness, radiance, pores and firmness*
- 87% of participants saw a reduction in the appearance of fine lines & wrinkles*
- 100% of participants saw improved skin smoothness and overall appearance*
- Participants skin’s barrier function improved by an average of + 15%*
*Shown in a 12-week clinical study performed by a third party research organization with 22 participants (OneSkin manuscript in process of publication)
The Science Behind OS-01 FACE
01
01 OS-01 FACE Can Increase Skin’s Epidermal Thickness
By conducting an epidermal thickness analysis of ex vivo human skin samples, our scientists found that skin treated with OS-01 FACE displayed a significant increase in epidermal thickness of 23.15%.03
Epidermal thickness analysis of ex vivo human skin samples topically exposed to nothing (NT) or OS-01 FACE. Treatment with OS-01 FACE induced a significant increase in epidermal thickness of 23.15%. Taken from the average of three measurements from each skin sample (35, 55, and 79 yr). *p<0.05
02
02 OS-01 FACE Increases Key Biomarkers Associated with Cell Proliferation and Collagen Production
In lab studies, our scientists exposed ex vivo human skin samples to either nothing (No Treatment) or OS-01 FACE, then evaluated the effect on key biomarkers associated with cell proliferation, MKI67, and collagen production, COL1A1.
Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. **p<0.01
Exposure to OS-01 FACE increased both biomarkers03, indicating that OS-01 FACE may promote cell proliferation and collagen production, which can promote firmer, more renewed skin.
03
OS-01 FACE Under the Microscope
We took a look at ex vivo human skin samples that were exposed to nothing (No Treatment) or OS-01 FACE under the microscope to observe the impact on skin’s morphology and structure.
Histology images of ex vivo human skin samples from a 35 year old donor exposed to nothing (No Treatment) vs OS-01 FACE.
From this imaging, we can see that treatment with OS-01 FACE promoted a more cohesive stratum corneum (top layer), with a more defined general structure and cellular organization, indicating that the skin’s barrier was likely strengthened and skin structure was improved when treated with OS-01 FACE.03
We can also visually confirm the increase in epidermal thickness (middle layer) that was observed in our epidermal thickness analysis, as expected.Exposure to OS-01 FACE increased both biomarkers, indicating that OS-01 FACE may promote cell proliferation and collagen production, which can promote firmer, more renewed skin.
01 Shown in lab-grown ex vivo human skin models
04
Retinol Increases a Key Marker Associated with Skin Aging. OS-01 FACE Does Not.
Our scientists exposed ex vivo human skin samples to OS-01 FACE and retinol, then analyzed key biomarkers associated with skin aging, CDKN2A, and collagen production, COL1A1, to determine their potential effect on skin at a molecular level.
Expression of biomarkers associated with skin aging (CDK2NA), and collagen production (COL1A1) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment), OS-01 FACE, or 1% retinol. *p<0.05
We found that while retinol was effective at significantly increasing a key biomarker associated with collagen production, COL1A1, it also led to a 10-fold increase in a key biomarker associated with aging, CDKN2A. Alternatively, treatment with OS-01 FACE was able to significantly increase the collagen production biomarker, COL1A1, at similar levels to retinol, without affecting the same biomarker associated with aging, CDKN2A, that retinol increased.03
To learn more about how OS-01 FACE compares to retinol, visit the Reference Lab!The Science Behind OS-01 FACE
01
01 OS-01 FACE Can Increase Skin’s Epidermal Thickness
By conducting an epidermal thickness analysis of ex vivo human skin samples, our scientists found that skin treated with OS-01 FACE displayed a significant increase in epidermal thickness of 23.15%.03
Epidermal thickness analysis of ex vivo human skin samples topically exposed to nothing (NT) or OS-01 FACE. Treatment with OS-01 FACE induced a significant increase in epidermal thickness of 23.15%. Taken from the average of three measurements from each skin sample (35, 55, and 79 yr). *p<0.05
02
02 OS-01 FACE Increases Key Biomarkers Associated with Cell Proliferation and Collagen Production
In lab studies, our scientists exposed ex vivo human skin samples to either nothing (No Treatment) or OS-01 FACE, then evaluated the effect on key biomarkers associated with cell proliferation, MKI67, and collagen production, COL1A1.
Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. **p<0.01
Exposure to OS-01 FACE increased both biomarkers03, indicating that OS-01 FACE may promote cell proliferation and collagen production, which can promote firmer, more renewed skin.
03
OS-01 FACE Under the Microscope
We took a look at ex vivo human skin samples that were exposed to nothing (No Treatment) or OS-01 FACE under the microscope to observe the impact on skin’s morphology and structure.
Histology images of ex vivo human skin samples from a 35 year old donor exposed to nothing (No Treatment) vs OS-01 FACE.
From this imaging, we can see that treatment with OS-01 FACE promoted a more cohesive stratum corneum (top layer), with a more defined general structure and cellular organization, indicating that the skin’s barrier was likely strengthened and skin structure was improved when treated with OS-01 FACE.03
We can also visually confirm the increase in epidermal thickness (middle layer) that was observed in our epidermal thickness analysis, as expected.Exposure to OS-01 FACE increased both biomarkers, indicating that OS-01 FACE may promote cell proliferation and collagen production, which can promote firmer, more renewed skin.
01 Shown in lab-grown ex vivo human skin models
04
Retinol Increases a Key Marker Associated with Skin Aging. OS-01 FACE Does Not.
Our scientists exposed ex vivo human skin samples to OS-01 FACE and retinol, then analyzed key biomarkers associated with skin aging, CDKN2A, and collagen production, COL1A1, to determine their potential effect on skin at a molecular level.
Expression of biomarkers associated with skin aging (CDK2NA), and collagen production (COL1A1) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment), OS-01 FACE, or 1% retinol. *p<0.05
We found that while retinol was effective at significantly increasing a key biomarker associated with collagen production, COL1A1, it also led to a 10-fold increase in a key biomarker associated with aging, CDKN2A. Alternatively, treatment with OS-01 FACE was able to significantly increase the collagen production biomarker, COL1A1, at similar levels to retinol, without affecting the same biomarker associated with aging, CDKN2A, that retinol increased.03
To learn more about how OS-01 FACE compares to retinol, visit the Reference Lab!