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Your Longevity Guide to Skin Health and Aging: A Deep Dive

Your Longevity Guide to Skin Health and Aging: A Deep Dive
When you look in the mirror, what story does your skin tell? Maybe it’s one of laughter, sunny days, or even a daring adventure that left behind a scar. Yet, skin is more than a visual record of your life; it’s a highly complex organ with a critical role in protecting you from external harm. It's also one of the first places you notice the visible signs of aging.But here’s the empowering truth: your skin's story is still being written. By understanding the biological processes driving skin agingβ€”like epigenetic shiftsβ€”you can take steps to support your skin’s health.
When you look in the mirror, what story does your skin tell? Maybe it’s one of laughter, sunny days, or even a daring adventure that left behind a scar. Yet, skin is more than a visual record of your life; it’s a highly complex organ with a critical role in protecting you from external harm. It's also one of the first places you notice the visible signs of aging.But here’s the empowering truth: your skin's story is still being written. By understanding the biological processes driving skin agingβ€”like epigenetic shiftsβ€”you can take steps to support your skin’s health.
01

The Science Behind Epigenetic Aging

Your chronological age is just a number, but your epigenetic or biological age tells a far richer story. Unlike your chronological age, epigenetic age measures changes in how your genes are expressed over time. After allβ€”skin aging isn’t randomβ€”factors like UV rays, pollution, poor nutrition, and stress can significantly accelerate (or slow) skin aging by influencing how your cells β€œread” your DNA, switching genes β€œon” or β€œoff” based through a process known as methylation.[1] These methylation levels can be very accurately measured, making epigenetic testing the go-to method for measuring a person’s overall health and mortality risk.[1]Using tools like an epigenetic clock, scientists can measure DNA methylation patterns that regulate gene activity. As you age, these patterns become less stable, contributing to disruptions in DNA methylation that can speed up hallmarks of aging, like cellular senescence, genomic instability, and loss of proteostasis.[2] Studies on twins have shown that even with identical genetics, differences in diet, environment, and habits create unique aging patterns.[3] The good news? You can take charge of your cellular aging with the right lifestyle choices, keeping your cells healthier for longer.
01

The Science Behind Epigenetic Aging

Your chronological age is just a number, but your epigenetic or biological age tells a far richer story. Unlike your chronological age, epigenetic age measures changes in how your genes are expressed over time. After allβ€”skin aging isn’t randomβ€”factors like UV rays, pollution, poor nutrition, and stress can significantly accelerate (or slow) skin aging by influencing how your cells β€œread” your DNA, switching genes β€œon” or β€œoff” based through a process known as methylation.[1] These methylation levels can be very accurately measured, making epigenetic testing the go-to method for measuring a person’s overall health and mortality risk.[1]Using tools like an epigenetic clock, scientists can measure DNA methylation patterns that regulate gene activity. As you age, these patterns become less stable, contributing to disruptions in DNA methylation that can speed up hallmarks of aging, like cellular senescence, genomic instability, and loss of proteostasis.[2] Studies on twins have shown that even with identical genetics, differences in diet, environment, and habits create unique aging patterns.[3] The good news? You can take charge of your cellular aging with the right lifestyle choices, keeping your cells healthier for longer.
02

The Factors of Skin Aging

By measuring indicators that can help track the health of your skin your skin, the factors of skin aging offer a window into how it’s aging and what it needs to stay healthy.[4] Addressing the underlying causes of these changes by taking preventative actions can slow the aging process and maintain the skin’s vitality. Let’s look closer at some of the most critical factors of skin aging and their biomarkers:

Hormone Health

One of the most impactful biomarkers of skin aging is the balance and levels of certain hormones. Estrogen, testosterone, and cortisol are essential for maintaining your skin's hydration, thickness, and elasticity.[5,6] They're even responsible for signaling the skin to repair itself. As you age, however, your hormone levels begin to decline and sometimes fluctuate.[7] Your unique epigenetic expression plays a large role in controlling this process and can make your skin thinner, drier, and more prone to wrinkles and acne.[8] Here are how changes in the most common hormones can affect the health of your skin:

Sex Hormones

While men's testosterone levels tend to decline gradually with age, leading to more steady signs of skin aging, women often experience a much more sudden decline in hormone levels during menopause.[7] Specifically, the decrease in estrogen can accelerate the visible signs of skin aging. Hormonal shifts don’t just alter appearance; they compromise the skin’s ability to function effectively. Estrogen is vital to collagen production, binding to fibroblasts and activating them to keep your skin firm, healthy, and supple.[5] During menopause, the sharp decline in estrogen levels means fibroblasts aren’t activated as effectively, reducing collagen production. Within the first five years of menopause, the skin loses about 30% of its collagen, causing it to thin considerably.[5]What you eat affects your hormonal health and, therefore, the longevity of your skin. After all, your body often needs help from your diet to produce the hormones it needs most. Adding phytoestrogen-rich foods like soy, flaxseeds, and legumes can help support hormonal balance naturally, especially for postmenopausal women.[9] While these won't help address the underlying epigenetic and age-related changes to your hormone levels, consuming plant-based compounds that act like estrogen can help keep your skin healthy.
02

The Factors of Skin Aging

By measuring indicators that can help track the health of your skin your skin, the factors of skin aging offer a window into how it’s aging and what it needs to stay healthy.[4] Addressing the underlying causes of these changes by taking preventative actions can slow the aging process and maintain the skin’s vitality. Let’s look closer at some of the most critical factors of skin aging and their biomarkers:

Hormone Health

One of the most impactful biomarkers of skin aging is the balance and levels of certain hormones. Estrogen, testosterone, and cortisol are essential for maintaining your skin's hydration, thickness, and elasticity.[5,6] They're even responsible for signaling the skin to repair itself. As you age, however, your hormone levels begin to decline and sometimes fluctuate.[7] Your unique epigenetic expression plays a large role in controlling this process and can make your skin thinner, drier, and more prone to wrinkles and acne.[8] Here are how changes in the most common hormones can affect the health of your skin:

Sex Hormones

While men's testosterone levels tend to decline gradually with age, leading to more steady signs of skin aging, women often experience a much more sudden decline in hormone levels during menopause.[7] Specifically, the decrease in estrogen can accelerate the visible signs of skin aging. Hormonal shifts don’t just alter appearance; they compromise the skin’s ability to function effectively. Estrogen is vital to collagen production, binding to fibroblasts and activating them to keep your skin firm, healthy, and supple.[5] During menopause, the sharp decline in estrogen levels means fibroblasts aren’t activated as effectively, reducing collagen production. Within the first five years of menopause, the skin loses about 30% of its collagen, causing it to thin considerably.[5]What you eat affects your hormonal health and, therefore, the longevity of your skin. After all, your body often needs help from your diet to produce the hormones it needs most. Adding phytoestrogen-rich foods like soy, flaxseeds, and legumes can help support hormonal balance naturally, especially for postmenopausal women.[9] While these won't help address the underlying epigenetic and age-related changes to your hormone levels, consuming plant-based compounds that act like estrogen can help keep your skin healthy.

Cortisol

Both stress and your epigenome can impact each other, affecting the health of your skin in various ways. When stress becomes chronic, levels of the stress hormone cortisol stay elevated, leading to changes in DNA methylation that elevate your body’s reactivity to cortisol levels.[10] In addition to accelerating the visible signs of aging like fine lines, dullness, and sagging by damaging collagen and weakening the skin’s protective barrier, elevated cortisol levels can speed up whole-body aging by increasing inflammation.[11,12]Simple stress management techniques can help reduce cortisol levels and make a big difference in your well-being. Mindfulness activities like yoga, deep breathing, and even optimizing your sleep schedule have been shown to significantly reduce cortisol levels.[13,14]

Cortisol

Both stress and your epigenome can impact each other, affecting the health of your skin in various ways. When stress becomes chronic, levels of the stress hormone cortisol stay elevated, leading to changes in DNA methylation that elevate your body’s reactivity to cortisol levels.[10] In addition to accelerating the visible signs of aging like fine lines, dullness, and sagging by damaging collagen and weakening the skin’s protective barrier, elevated cortisol levels can speed up whole-body aging by increasing inflammation.[11,12]Simple stress management techniques can help reduce cortisol levels and make a big difference in your well-being. Mindfulness activities like yoga, deep breathing, and even optimizing your sleep schedule have been shown to significantly reduce cortisol levels.[13,14]

Immune Health

Your skin isn’t just a barrierβ€”it’s an active part of your immune system. It houses immune cells that act like sentries, ready to respond to threats and maintain balance in the tissue. When your skin gets injured, these cells coordinate a response to help repair the damage and, if needed, call in reinforcements from the rest of your immune system.[15]However, with age, immune function declines due to processes like immunosenescence, where dysfunctional cells build up and fail to do their job, a process that can be driven by epigenetic alterations.[16] This decline is often paired with inflammagingβ€”a state of chronic inflammation fueled by stress, poor dietary choices, and physical inactivity. These changes impair the activity of immune cells, reducing their efficiency in combating infections, responding to vaccines, healing wounds, and repairing skin.[15,17]The good news? One easy way to help your immune system is by making sure you’re getting enough zinc. This essential mineral enhances immune cell function, reduces inflammation, and supports skin repair. Zinc deficiencies are common in older adults, but incorporating foods like flaxseeds, chickpeas, and pumpkin seeds into your dietβ€”or using a supplementβ€”can help keep your immune system strong and resilient.[18] Combining this with healthy practices like regular physical activity and proper hydration gives your immune system everything it needs to protect your body and keep your skin vibrant.[19]

Immune Health

Your skin isn’t just a barrierβ€”it’s an active part of your immune system. It houses immune cells that act like sentries, ready to respond to threats and maintain balance in the tissue. When your skin gets injured, these cells coordinate a response to help repair the damage and, if needed, call in reinforcements from the rest of your immune system.[15]However, with age, immune function declines due to processes like immunosenescence, where dysfunctional cells build up and fail to do their job, a process that can be driven by epigenetic alterations.[16] This decline is often paired with inflammagingβ€”a state of chronic inflammation fueled by stress, poor dietary choices, and physical inactivity. These changes impair the activity of immune cells, reducing their efficiency in combating infections, responding to vaccines, healing wounds, and repairing skin.[15,17]The good news? One easy way to help your immune system is by making sure you’re getting enough zinc. This essential mineral enhances immune cell function, reduces inflammation, and supports skin repair. Zinc deficiencies are common in older adults, but incorporating foods like flaxseeds, chickpeas, and pumpkin seeds into your dietβ€”or using a supplementβ€”can help keep your immune system strong and resilient.[18] Combining this with healthy practices like regular physical activity and proper hydration gives your immune system everything it needs to protect your body and keep your skin vibrant.[19]

Gut Health

Your gut microbiome, the community of trillions of microorganisms living in your digestive tract, is integral to overall health. It influences immune function, mood regulation, systemic inflammation, and skin health. With age, the balance of this microbiome can shift, leading to a decline in beneficial bacteria and an increase in harmful microbesβ€”a phenomenon linked to age-related diseases like Alzheimer’s and Parkinson’s.[20]The connection between gut and skin health is profound. Beneficial gut bacteria help produce short-chain fatty acids (SCFAs), such as butyrate, which reduce inflammation and support the skin’s barrier function.[21] Research has shown that prebiotic fibers like inulin (found in garlic, onions, and asparagus) and beta-glucans (present in oats and mushrooms) feed beneficial bacteria like Bifidobacteria.[21] Incorporating these prebiotics into your diet can encourage a thriving gut microbiome, boosting SCFA production and mitigating inflammation.Surprisingly, your environment matters, too. Spending time outdoors, especially in nature or gardening, exposes you to soil microbes that increase the diversity of your gut and skin microbiomes.[22] A more diverse microbiome leads to better immune function, reduced inflammation, and healthier, more resilient skin. So, whether you’re adding prebiotic-rich foods to your diet or enjoying time outside, there are many ways to keep your gutβ€”and your skinβ€”thriving.[23]

Gut Health

Your gut microbiome, the community of trillions of microorganisms living in your digestive tract, is integral to overall health. It influences immune function, mood regulation, systemic inflammation, and skin health. With age, the balance of this microbiome can shift, leading to a decline in beneficial bacteria and an increase in harmful microbesβ€”a phenomenon linked to age-related diseases like Alzheimer’s and Parkinson’s.[20]The connection between gut and skin health is profound. Beneficial gut bacteria help produce short-chain fatty acids (SCFAs), such as butyrate, which reduce inflammation and support the skin’s barrier function.[21] Research has shown that prebiotic fibers like inulin (found in garlic, onions, and asparagus) and beta-glucans (present in oats and mushrooms) feed beneficial bacteria like Bifidobacteria.[21] Incorporating these prebiotics into your diet can encourage a thriving gut microbiome, boosting SCFA production and mitigating inflammation.Surprisingly, your environment matters, too. Spending time outdoors, especially in nature or gardening, exposes you to soil microbes that increase the diversity of your gut and skin microbiomes.[22] A more diverse microbiome leads to better immune function, reduced inflammation, and healthier, more resilient skin. So, whether you’re adding prebiotic-rich foods to your diet or enjoying time outside, there are many ways to keep your gutβ€”and your skinβ€”thriving.[23]

Cardiovascular Health

Your heart and blood vessels work tirelessly to deliver oxygen and nutrients to your skin, keeping it healthy, vibrant, and able to repair itself. Unfortunately, aging can make this process less efficient as your blood vessels lose their elasticity, making it harder for blood to circulate efficiently.[24] This decline can lead to visible effects on the skin, such as dullness, uneven tone, and slower wound healing. Studies have also linked accelerated epigenetic aging to higher risks of hypertension and poor circulation, which can further impact skin health.[25,26]If you’re looking for a way to boost circulation and support your skin, consider sauna sessions. Saunas promote better blood flow by relaxing blood vessels, making it easier for oxygen and nutrients to reach your skin. A 20-year study showed that people who used saunas frequentlyβ€”four to seven times per weekβ€”had significantly lower mortality rates from heart disease and stroke.[27]Combining saunas with exercise provides even more significant benefits. Research finds that just 15 minutes in a sauna after a workout three times a week led to more substantial reductions in blood pressure than exercise alone.[28] Together, these practices strengthen your cardiovascular system, improve circulation, and help your skin look and feel its best.

Cardiovascular Health

Your heart and blood vessels work tirelessly to deliver oxygen and nutrients to your skin, keeping it healthy, vibrant, and able to repair itself. Unfortunately, aging can make this process less efficient as your blood vessels lose their elasticity, making it harder for blood to circulate efficiently.[24] This decline can lead to visible effects on the skin, such as dullness, uneven tone, and slower wound healing. Studies have also linked accelerated epigenetic aging to higher risks of hypertension and poor circulation, which can further impact skin health.[25,26]If you’re looking for a way to boost circulation and support your skin, consider sauna sessions. Saunas promote better blood flow by relaxing blood vessels, making it easier for oxygen and nutrients to reach your skin. A 20-year study showed that people who used saunas frequentlyβ€”four to seven times per weekβ€”had significantly lower mortality rates from heart disease and stroke.[27]Combining saunas with exercise provides even more significant benefits. Research finds that just 15 minutes in a sauna after a workout three times a week led to more substantial reductions in blood pressure than exercise alone.[28] Together, these practices strengthen your cardiovascular system, improve circulation, and help your skin look and feel its best.
03

Taking Control of Your Skin and Longevity

Next time you look in the mirror, remember that aging is about more than what you see in the mirror. It’s about how your body, and in this case, your skin, functions at the cellular level. That’s where our proprietary innovation, MolClock, comes in.The first machine-learning algorithm to accurately predict the biological age of skin based on DNA methylation, MolClock is a key part of our R&D process.[29] It provides a unique opportunity to measure the safety and efficacy of our OS-01 peptide and topical supplements beneath the surface.[30]But healthy aging doesn’t stop at the skin. Our partners at Tally Health offer advanced epigenetic testing to help you discover your whole body’s biological age, plus supplements that support energy, metabolism, sleep, cognition, and immunityβ€”all built on decades of cellular aging research. These products are designed to help you take control of how you age, targeting the same hallmarks of aging that OneSkin’s OS-01 technology addresses, including cellular senescence. Together, these tools offer you a comprehensive plan to age healthier, both inside and out. For a limited time, use code ONESKIN to receive 20% off your first month of Tally Health supplements.
03

Taking Control of Your Skin and Longevity

Next time you look in the mirror, remember that aging is about more than what you see in the mirror. It’s about how your body, and in this case, your skin, functions at the cellular level. That’s where our proprietary innovation, MolClock, comes in.The first machine-learning algorithm to accurately predict the biological age of skin based on DNA methylation, MolClock is a key part of our R&D process.[29] It provides a unique opportunity to measure the safety and efficacy of our OS-01 peptide and topical supplements beneath the surface.[30]But healthy aging doesn’t stop at the skin. Our partners at Tally Health offer advanced epigenetic testing to help you discover your whole body’s biological age, plus supplements that support energy, metabolism, sleep, cognition, and immunityβ€”all built on decades of cellular aging research. These products are designed to help you take control of how you age, targeting the same hallmarks of aging that OneSkin’s OS-01 technology addresses, including cellular senescence. Together, these tools offer you a comprehensive plan to age healthier, both inside and out. For a limited time, use code ONESKIN to receive 20% off your first month of Tally Health supplements.
Key Takeaways:
  • Your skin is more than a visual record of your life; it’s a complex organ that protects you from external stressors while reflecting your overall health.
  • Aging isn’t just about getting older; lifestyle habits can switch genes β€œon” or β€œoff” through epigenetics, speeding up or slowing down skin aging.
  • Epigenetic changes throughout your body can influence several key skin health factors, including hormones, stress, immune function, gut microbiome, and cardiovascular health.
  • Want to age healthier? OneSkin and Tally Health provide tools and supplements to support the well-being of your skin and other vital organs.
Key Takeaways:
  • Your skin is more than a visual record of your life; it’s a complex organ that protects you from external stressors while reflecting your overall health.
  • Aging isn’t just about getting older; lifestyle habits can switch genes β€œon” or β€œoff” through epigenetics, speeding up or slowing down skin aging.
  • Epigenetic changes throughout your body can influence several key skin health factors, including hormones, stress, immune function, gut microbiome, and cardiovascular health.
  • Want to age healthier? OneSkin and Tally Health provide tools and supplements to support the well-being of your skin and other vital organs.
References
  1. https://academic.oup.com/biomedgerontology/article/79/1/glad242/7332024
  2. https://www.sciencedirect.com/science/article/pii/S0047637417302671?via%3Dihub
  3. https://www.pnas.org/doi/full/10.1073/pnas.0500398102
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC11323771/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC3772914/
  6. https://pmc.ncbi.nlm.nih.gov/articles/PMC8955788/
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC8020896/
  8. https://pmc.ncbi.nlm.nih.gov/articles/PMC4071959/
  9. https://www.mdpi.com/2076-3921/10/12/1893
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC3329877/
  11. https://www.ncbi.nlm.nih.gov/books/NBK493173/
  12. https://pmc.ncbi.nlm.nih.gov/articles/PMC4082169/
  13. https://pmc.ncbi.nlm.nih.gov/articles/PMC3768222/
  14. https://pubmed.ncbi.nlm.nih.gov/35777076/
  15. https://pmc.ncbi.nlm.nih.gov/articles/PMC6515324/
  16. https://www.tandfonline.com/doi/full/10.1080/15592294.2020.1712814
  17. https://www.nature.com/articles/s41569-018-0064-2
  18. https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-6-9
  19. https://pmc.ncbi.nlm.nih.gov/articles/PMC7146449/
  20. https://pmc.ncbi.nlm.nih.gov/articles/PMC10798364/
  21. https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01307-x
  22. https://www.tandfonline.com/doi/full/10.2217/fmb-2017-0286
  23. https://onlinelibrary.wiley.com/doi/10.1002/mbo3.645
  24. https://pmc.ncbi.nlm.nih.gov/articles/PMC7556287/
  25. https://link.springer.com/article/10.1007/s11357-022-00714-0
  26. https://www.aginganddisease.org/EN/10.14336/AD.2019.0315
  27. https://pubmed.ncbi.nlm.nih.gov/25705824/
  28. https://pubmed.ncbi.nlm.nih.gov/35785965/
  29. Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
  30. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
References
  1. https://academic.oup.com/biomedgerontology/article/79/1/glad242/7332024
  2. https://www.sciencedirect.com/science/article/pii/S0047637417302671?via%3Dihub
  3. https://www.pnas.org/doi/full/10.1073/pnas.0500398102
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC11323771/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC3772914/
  6. https://pmc.ncbi.nlm.nih.gov/articles/PMC8955788/
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC8020896/
  8. https://pmc.ncbi.nlm.nih.gov/articles/PMC4071959/
  9. https://www.mdpi.com/2076-3921/10/12/1893
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC3329877/
  11. https://www.ncbi.nlm.nih.gov/books/NBK493173/
  12. https://pmc.ncbi.nlm.nih.gov/articles/PMC4082169/
  13. https://pmc.ncbi.nlm.nih.gov/articles/PMC3768222/
  14. https://pubmed.ncbi.nlm.nih.gov/35777076/
  15. https://pmc.ncbi.nlm.nih.gov/articles/PMC6515324/
  16. https://www.tandfonline.com/doi/full/10.1080/15592294.2020.1712814
  17. https://www.nature.com/articles/s41569-018-0064-2
  18. https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-6-9
  19. https://pmc.ncbi.nlm.nih.gov/articles/PMC7146449/
  20. https://pmc.ncbi.nlm.nih.gov/articles/PMC10798364/
  21. https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01307-x
  22. https://www.tandfonline.com/doi/full/10.2217/fmb-2017-0286
  23. https://onlinelibrary.wiley.com/doi/10.1002/mbo3.645
  24. https://pmc.ncbi.nlm.nih.gov/articles/PMC7556287/
  25. https://link.springer.com/article/10.1007/s11357-022-00714-0
  26. https://www.aginganddisease.org/EN/10.14336/AD.2019.0315
  27. https://pubmed.ncbi.nlm.nih.gov/25705824/
  28. https://pubmed.ncbi.nlm.nih.gov/35785965/
  29. Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
  30. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

Last Updated February 26, 2025

Reviewed by

Alessandra Zonari

Alessandra Zonari

PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.