The Skincare Upgrade You Didn’t Know You Needed: Topical Supplements
4 min read
JANUARY 17,2025
SKIN SCIENCE
The Skincare Upgrade You Didn’t Know You Needed: Topical Supplements
4 min read
JANUARY 17,2025
SKIN SCIENCE
Have you ever wondered if your skin care products even work? Here’s the harsh truth: most skin care products aren’t grounded in science. Many brands develop their products in partnership with third-party manufacturers that rarely empirically test the efficacy of their formulas.At OneSkin, we saw a need for change. After testing the effects of popular so-called “anti-aging” products at the cellular level in our lab, we found that most were ineffective at slowing or reversing skin aging. What's worse, some of the most popular options are harmful at the cellular level, disrupting the skin barrier and potentially accelerating skin aging. That discovery fueled our mission to create innovative skin health products backed by objective scientific evidence. Starting in 2016, our passionate team of female PhDs embarked on an exciting journey to develop a peptide capable of reversing the biological age of skin by keeping it healthier for longer. Our team analyzed over 900 peptides using state-of-the-art computational algorithms and advanced skin age modeling, ultimately uncovering the strongest contender, OS-01, the first peptide proven to reverse skin’s biological age by reducing cellular senescence. The result is our collection of topical supplements centered around the OS-01 peptide: skin care proven to reverse the signs of skin aging from the cellular level up to visible benefits.[1]
Have you ever wondered if your skin care products even work? Here’s the harsh truth: most skin care products aren’t grounded in science. Many brands develop their products in partnership with third-party manufacturers that rarely empirically test the efficacy of their formulas.At OneSkin, we saw a need for change. After testing the effects of popular so-called “anti-aging” products at the cellular level in our lab, we found that most were ineffective at slowing or reversing skin aging. What's worse, some of the most popular options are harmful at the cellular level, disrupting the skin barrier and potentially accelerating skin aging. That discovery fueled our mission to create innovative skin health products backed by objective scientific evidence. Starting in 2016, our passionate team of female PhDs embarked on an exciting journey to develop a peptide capable of reversing the biological age of skin by keeping it healthier for longer. Our team analyzed over 900 peptides using state-of-the-art computational algorithms and advanced skin age modeling, ultimately uncovering the strongest contender, OS-01, the first peptide proven to reverse skin’s biological age by reducing cellular senescence. The result is our collection of topical supplements centered around the OS-01 peptide: skin care proven to reverse the signs of skin aging from the cellular level up to visible benefits.[1]
01
What is a Topical Supplement?
Think of a topical supplement like a multivitamin—but for your skin. You take vitamins to keep your body running smoothly, so why not give your skin the same love? OneSkin’s topical supplements are more than just skin care–they’re designed to support whole-body health, starting with your largest organ (your skin!). When integrating them into your routine, you can treat OneSkin’s topical supplements as moisturizers, but you’ll quickly find they go far beyond your average daily skin care products.
01
What is a Topical Supplement?
Think of a topical supplement like a multivitamin—but for your skin. You take vitamins to keep your body running smoothly, so why not give your skin the same love? OneSkin’s topical supplements are more than just skin care–they’re designed to support whole-body health, starting with your largest organ (your skin!). When integrating them into your routine, you can treat OneSkin’s topical supplements as moisturizers, but you’ll quickly find they go far beyond your average daily skin care products.
02
Why Are OneSkin’s Topical Supplements Unique?
What sets OneSkin’s topical supplements apart? Simple—they don't just address your skin's visible needs; they transform how it ages. Powered by our groundbreaking OS-01 peptide, antioxidants, and other proven longevity-boosting ingredients, our topical supplements target the root causes of aging at the cellular level. Whether you’re battling dryness, fine lines, or uneven skin tone, our formulas get to the root of your skin needs.[1]Backed by lab and clinical testing to validate their benefits, our topical supplements harness the power of OS-01 to give you skin that looks, feels, and acts healthier. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin:
02
Why Are OneSkin’s Topical Supplements Unique?
What sets OneSkin’s topical supplements apart? Simple—they don't just address your skin's visible needs; they transform how it ages. Powered by our groundbreaking OS-01 peptide, antioxidants, and other proven longevity-boosting ingredients, our topical supplements target the root causes of aging at the cellular level. Whether you’re battling dryness, fine lines, or uneven skin tone, our formulas get to the root of your skin needs.[1]Backed by lab and clinical testing to validate their benefits, our topical supplements harness the power of OS-01 to give you skin that looks, feels, and acts healthier. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin:
OS-01 FACE
A typical moisturizer may hydrate your skin, but OS-01 FACE does so much more. Over time, skin aging diminishes the thickness and strength of the epidermis, leaving skin more fragile and prone to visible signs of aging. OS-01 FACE combats this process by actively promoting skin's natural collagen production and increasing skin’s epidermal thickness.[1,2] This helps relieve visible signs of aging—like fine lines and wrinkles—while allowing your skin to better resist long-term signs of aging.[3]In addition to our lab testing, OneSkin’s OS-01 FACE clinical study has been published in the peer-reviewed Journal of Cosmetic Dermatology. Here are some of the exciting results:
- 100% of users experienced smoother, better appearing skin.[3]
- 95.5% exhibited a boost in radiance, evenness, and firmness.[3]
- 90% experienced improved elasticity.[3]
- 86% displayed a reduction in fine lines and wrinkles.[3]
OS-01 FACE
A typical moisturizer may hydrate your skin, but OS-01 FACE does so much more. Over time, skin aging diminishes the thickness and strength of the epidermis, leaving skin more fragile and prone to visible signs of aging. OS-01 FACE combats this process by actively promoting skin's natural collagen production and increasing skin’s epidermal thickness.[1,2] This helps relieve visible signs of aging—like fine lines and wrinkles—while allowing your skin to better resist long-term signs of aging.[3]In addition to our lab testing, OneSkin’s OS-01 FACE clinical study has been published in the peer-reviewed Journal of Cosmetic Dermatology. Here are some of the exciting results:
- 100% of users experienced smoother, better appearing skin.[3]
- 95.5% exhibited a boost in radiance, evenness, and firmness.[3]
- 90% experienced improved elasticity.[3]
- 86% displayed a reduction in fine lines and wrinkles.[3]
OS-01 EYE
The skin around your eyes works overtime to express your emotions and endure environmental stress—it even accumulates a higher amount of senescent cells—this means it's often the first part of your skin to show the signs of aging.[4] That’s where OS-01 EYE steps in. OneSkin’s most potent formula, OS-01 EYE, is enriched with the highest concentration of the OS-01 peptide—and other skin-longevity boosting ingredients like argirilene and CoQ10—and is specifically designed to slow the visible and invisible signs of skin aging around the eyes.[1]We've recently published the results of our OS-01 EYE clinical study. These are some of the results that we think you'll love:
- 86% of users experienced improved skin elasticity.[5]
- 87.5% of participants saw hydration levels increase by an average of 32%.[5]
- 17% average improvement in skin barrier function.[5]
- 96% of users noticed an enhanced overall appearance.[4]
OS-01 EYE
The skin around your eyes works overtime to express your emotions and endure environmental stress—it even accumulates a higher amount of senescent cells—this means it's often the first part of your skin to show the signs of aging.[4] That’s where OS-01 EYE steps in. OneSkin’s most potent formula, OS-01 EYE, is enriched with the highest concentration of the OS-01 peptide—and other skin-longevity boosting ingredients like argirilene and CoQ10—and is specifically designed to slow the visible and invisible signs of skin aging around the eyes.[1]We've recently published the results of our OS-01 EYE clinical study. These are some of the results that we think you'll love:
- 86% of users experienced improved skin elasticity.[5]
- 87.5% of participants saw hydration levels increase by an average of 32%.[5]
- 17% average improvement in skin barrier function.[5]
- 96% of users noticed an enhanced overall appearance.[4]
OS-01 BODY
Your skin is your body’s largest organ, yet traditional skin care routines focus almost exclusively on the face, leaving most of your skin overlooked. The OS-01 BODY topical supplement strengthens and rejuvenates body skin, addressing age-related vulnerabilities with science-backed precision.[1]By targeting some of the most prominent age-related skin issues like thinning and dryness, OS-01 BODY provides some impressive results in just 12 weeks:
- 41.49% average improvement in skin barrier function.[1]
- 93% of users saw their skin hydration improve by an average of +38.34%.[1]
- OS-01 BODY significantly reduces circulating inflammatory cytokine, IL-8, a key biomarker of systemic inflammation.[1]
OS-01 BODY
Your skin is your body’s largest organ, yet traditional skin care routines focus almost exclusively on the face, leaving most of your skin overlooked. The OS-01 BODY topical supplement strengthens and rejuvenates body skin, addressing age-related vulnerabilities with science-backed precision.[1]By targeting some of the most prominent age-related skin issues like thinning and dryness, OS-01 BODY provides some impressive results in just 12 weeks:
- 41.49% average improvement in skin barrier function.[1]
- 93% of users saw their skin hydration improve by an average of +38.34%.[1]
- OS-01 BODY significantly reduces circulating inflammatory cytokine, IL-8, a key biomarker of systemic inflammation.[1]
Related Products
Related Products
Key Takeaways:
- Skin care meets science with topical supplements, delivering proven longevity benefits to address aging at the cellular level and improve key skin health markers.
- Powered by the OS-01 peptide, OneSkin’s topical supplements target aging at the cellular level, ensuring stronger, healthier skin over time.
- Backed by extensive lab research and peer-reviewed clinical studies, OS-01 FACE, OS-01 EYE, and OS-01 BODY deliver targeted care to keep your skin barrier healthy and youthful from head to toe.
Key Takeaways:
- Skin care meets science with topical supplements, delivering proven longevity benefits to address aging at the cellular level and improve key skin health markers.
- Powered by the OS-01 peptide, OneSkin’s topical supplements target aging at the cellular level, ensuring stronger, healthier skin over time.
- Backed by extensive lab research and peer-reviewed clinical studies, OS-01 FACE, OS-01 EYE, and OS-01 BODY deliver targeted care to keep your skin barrier healthy and youthful from head to toe.
Disclaimers
This article was initially published in December 2020 and has been updated.
Disclaimers
This article was initially published in December 2020 and has been updated.
References
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
- Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
- https://www.jaad.org/article/S0190-9622(16)00242-5/abstract
- Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
References
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
- Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
- https://www.jaad.org/article/S0190-9622(16)00242-5/abstract
- Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
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How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
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Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
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Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
Peptides: The First Piece Of The Skin Longevity Pu...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging