Target Cellular Senescence with the Highest Concentration of the OS-01 Peptide
4 min read
THE ONESKIN TEAM
March 20,2023
FROM THE ONESKIN LAB
Target Cellular Senescence with the Highest Concentration of the OS-01 Peptide
4 min read
THE ONESKIN TEAM
March 20,2023
FROM THE ONESKIN LAB
With just a quick glance, it’s easy to see that the skin around the eyes is fundamentally different from the rest of the skin on your face. Not only is it far thinner than the skin on your cheeks or forehead, it actually ages faster than the rest of your skin, which might be why many of us start to notice under-eye wrinkles as early as our 20s. But what’s happening beyond these surface-level wrinkles? At the cellular level, under-eye skin behaves differently than the rest of your skin –showing accelerated signs of cellular senescence, one of the 9 hallmarks of aging. Join us as we take a closer look at cellular senescence and what it means for the delicate skin around your eyes.
With just a quick glance, it’s easy to see that the skin around the eyes is fundamentally different from the rest of the skin on your face. Not only is it far thinner than the skin on your cheeks or forehead, it actually ages faster than the rest of your skin, which might be why many of us start to notice under-eye wrinkles as early as our 20s. But what’s happening beyond these surface-level wrinkles? At the cellular level, under-eye skin behaves differently than the rest of your skin –showing accelerated signs of cellular senescence, one of the 9 hallmarks of aging. Join us as we take a closer look at cellular senescence and what it means for the delicate skin around your eyes.
01
What is cellular senescence?
One of the twelve hallmarks of aging, cellular senescence is a central driver of skin aging. Derived from the Latin root senex, meaning “old age,” senescence is the end stage in a cell’s life cycle when it stops dividing.Cells become senescent when they accumulate too much intrinsic and extrinsic damage, driving them into a zombie-like state of dysfunction. Senescent cells secrete harmful biochemical signals, called SASP, that drive the aging process–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. These signals can even inhibit stem cell function, decreasing your tissues’ ability to regenerate.While cellular senescence is happening constantly in our bodies throughout our lifetimes, it only becomes a problem when our bodies can no longer keep up with the rate of senescence. When we’re young, our immune system can quickly clear away senescent cells, limiting their impact. But as we grow older, our bodies become less efficient at removing senescent cells, leading to key characteristics of aging. [1]
01
What is cellular senescence?
One of the twelve hallmarks of aging, cellular senescence is a central driver of skin aging. Derived from the Latin root senex, meaning “old age,” senescence is the end stage in a cell’s life cycle when it stops dividing.Cells become senescent when they accumulate too much intrinsic and extrinsic damage, driving them into a zombie-like state of dysfunction. Senescent cells secrete harmful biochemical signals, called SASP, that drive the aging process–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. These signals can even inhibit stem cell function, decreasing your tissues’ ability to regenerate.While cellular senescence is happening constantly in our bodies throughout our lifetimes, it only becomes a problem when our bodies can no longer keep up with the rate of senescence. When we’re young, our immune system can quickly clear away senescent cells, limiting their impact. But as we grow older, our bodies become less efficient at removing senescent cells, leading to key characteristics of aging. [1]
02
Higher cellular senescence in under-eye skin
To understand why the skin around the eyes ages faster than other areas of the face, scientists analyzed the expression of a key senescence marker, CDK2NA, in periocular skin. What they found was that, in both the epidermal and dermal layers, periocular skin expressed significantly higher levels of cellular senescence than other areas of the face. The same study also found that DNA repair pathways were lower in periocular skin, suggesting that DNA repair insufficiency may be an underlying factor in rapid signs of visible aging. [2]
02
Higher cellular senescence in under-eye skin
To understand why the skin around the eyes ages faster than other areas of the face, scientists analyzed the expression of a key senescence marker, CDK2NA, in periocular skin. What they found was that, in both the epidermal and dermal layers, periocular skin expressed significantly higher levels of cellular senescence than other areas of the face. The same study also found that DNA repair pathways were lower in periocular skin, suggesting that DNA repair insufficiency may be an underlying factor in rapid signs of visible aging. [2]
03
Reduce cellular senescence with the OS-01 peptide
By reducing cellular senescence, it’s possible to actually reverse biological aging at the cellular level–helping the delicate skin around the eyes stay healthier for longer. So how can you reduce cellular senescence? With OS-01: the first peptide proven to reduce cellular senescence. [3,4] In lab studies, the OS-01 peptide has been shown to reverse the same senescence marker, CDK2NA, in skin cells in vitro, that are particularly affected in periocular skin. Additionally, the OS-01 peptide can reduce a key DNA damage marker, γH2A.x. [3,4] Let’s take a closer look at how the OS-01 peptide works at the cellular level to reduce cellular senescence and support DNA damage repair.
03
Reduce cellular senescence with the OS-01 peptide
By reducing cellular senescence, it’s possible to actually reverse biological aging at the cellular level–helping the delicate skin around the eyes stay healthier for longer. So how can you reduce cellular senescence? With OS-01: the first peptide proven to reduce cellular senescence. [3,4] In lab studies, the OS-01 peptide has been shown to reverse the same senescence marker, CDK2NA, in skin cells in vitro, that are particularly affected in periocular skin. Additionally, the OS-01 peptide can reduce a key DNA damage marker, γH2A.x. [3,4] Let’s take a closer look at how the OS-01 peptide works at the cellular level to reduce cellular senescence and support DNA damage repair.
04
The OS-01 peptide significantly reduces key cellular senescence marker, CDK2NA, in ex vivo human skin samples
Remember the cellular senescence marker that scientists studied in periocular skin? OS-01 has been proven to reduce that exact marker–CDKN2A– in ex vivo human skin samples. In a lab study conducted by the OneSkin scientific team, the OS-01 peptide reduced CDKN2A in both the dermal and epidermal layers after 5 days of treatment. [3,4] This shows that the OS-01 peptide could effectively mitigate the natural elevation of cellular senescence in skin, thereby preventing accelerated signs of skin aging.
04
The OS-01 peptide significantly reduces key cellular senescence marker, CDK2NA, in ex vivo human skin samples
Remember the cellular senescence marker that scientists studied in periocular skin? OS-01 has been proven to reduce that exact marker–CDKN2A– in ex vivo human skin samples. In a lab study conducted by the OneSkin scientific team, the OS-01 peptide reduced CDKN2A in both the dermal and epidermal layers after 5 days of treatment. [3,4] This shows that the OS-01 peptide could effectively mitigate the natural elevation of cellular senescence in skin, thereby preventing accelerated signs of skin aging.
mRNA expression analysis of ex vivo human skin samples (35, 55, and 79 yr) exposed to the OS-01 peptide (12.5uM) over 5 days, analyzed in the dermis and epidermis. (Zonari, et al, npj Aging, 2023)
mRNA expression analysis of ex vivo human skin samples (35, 55, and 79 yr) exposed to the OS-01 peptide (12.5uM) over 5 days, analyzed in the dermis and epidermis. (Zonari, et al, npj Aging, 2023)
05
The OS-01 peptide reduces a key DNA damage marker, γH2A.x, in skin cells in vitro
In addition to higher cellular senescence, scientists found that periocular skin shows decreased DNA repair pathways. To determine whether OS-01 could address this DNA repair insufficiency, our scientists analyzed in vitro skin derived from patients with Hutchinson-Gilford progeria syndrome, a genetic condition that causes premature skin aging with a high level of cellular senescence.After treating the skin samples with the OS-01 peptide for 48 hrs, they performed a protein expression analysis to see how the peptide would alter protein levels in skin. They found that a key DNA damage marker, γH2A.x, was significantly reduced, indicating the OS-01 peptide’s potential ability to aid in DNA damage repair. [3,4]
05
The OS-01 peptide reduces a key DNA damage marker, γH2A.x, in skin cells in vitro
In addition to higher cellular senescence, scientists found that periocular skin shows decreased DNA repair pathways. To determine whether OS-01 could address this DNA repair insufficiency, our scientists analyzed in vitro skin derived from patients with Hutchinson-Gilford progeria syndrome, a genetic condition that causes premature skin aging with a high level of cellular senescence.After treating the skin samples with the OS-01 peptide for 48 hrs, they performed a protein expression analysis to see how the peptide would alter protein levels in skin. They found that a key DNA damage marker, γH2A.x, was significantly reduced, indicating the OS-01 peptide’s potential ability to aid in DNA damage repair. [3,4]
Protein expression analysis for γH2A.x in HGPS fibroblasts in vitro treated with 12.5 μM OS-01 peptide for 48 hr.(Zonari, et al, npj Aging, 2023)
Protein expression analysis for γH2A.x in HGPS fibroblasts in vitro treated with 12.5 μM OS-01 peptide for 48 hr.(Zonari, et al, npj Aging, 2023)
06
The OS-01 peptide promotes a reduction in senescent cells in human fibroblast cultures in vitro
To further confirm the OS-01 peptide’s ability to reduce senescent burden in skin, our team took a look at the quantity of senescent cells in skin to determine if the OS-01 peptide effectively reduced their number. Our team treated in vitro fibroblast cultures derived from HGPS patients with senescence-associated beta galactosidase, a compound that selectively stains senescent cells blue, and counted the number of senescent cells before and after treatment with the OS-O1 peptide.
06
The OS-01 peptide promotes a reduction in senescent cells in human fibroblast cultures in vitro
To further confirm the OS-01 peptide’s ability to reduce senescent burden in skin, our team took a look at the quantity of senescent cells in skin to determine if the OS-01 peptide effectively reduced their number. Our team treated in vitro fibroblast cultures derived from HGPS patients with senescence-associated beta galactosidase, a compound that selectively stains senescent cells blue, and counted the number of senescent cells before and after treatment with the OS-O1 peptide.
SA B-Gal (senescence-associated beta galactosidase) stained image of HGPS HDFs (human dermal fibroblasts from patient-derived samples with Hutchinson-Gilford progeria syndrome) treated with 50uM OS-01 peptide for 2 days compared to untreated control. (Zonari, et al, npj Aging, 2023)
SA B-Gal (senescence-associated beta galactosidase) stained image of HGPS HDFs (human dermal fibroblasts from patient-derived samples with Hutchinson-Gilford progeria syndrome) treated with 50uM OS-01 peptide for 2 days compared to untreated control. (Zonari, et al, npj Aging, 2023)
In this study, our scientists found that exposure to the OS-01 peptide promoted the reduction of senescent cells (blue) by up to 50% while maintaining the total number of cells. [3,4] This means that the OS-01 peptide promoted not just the reduction of senescent cells, but also the renewal of healthier ones.
In this study, our scientists found that exposure to the OS-01 peptide promoted the reduction of senescent cells (blue) by up to 50% while maintaining the total number of cells. [3,4] This means that the OS-01 peptide promoted not just the reduction of senescent cells, but also the renewal of healthier ones.
07
Target senescence with more OS-01 peptide
Formulated with the highest concentration of our OS-01 peptide, our OS-01 EYE Topical Supplement was specifically designed to treat the delicate skin around the eyes. By testing the full formulation of OS-01 EYE on human eyelid skin, we further confirmed OS-01 EYE’s ability to reduce senescent burden in periocular skin. In a lab study, OS-01 EYE was shown to reduce CDKN2A, a key marker associated with cellular senescence, in ex vivo human eyelid skin samples. [4]
07
Target senescence with more OS-01 peptide
Formulated with the highest concentration of our OS-01 peptide, our OS-01 EYE Topical Supplement was specifically designed to treat the delicate skin around the eyes. By testing the full formulation of OS-01 EYE on human eyelid skin, we further confirmed OS-01 EYE’s ability to reduce senescent burden in periocular skin. In a lab study, OS-01 EYE was shown to reduce CDKN2A, a key marker associated with cellular senescence, in ex vivo human eyelid skin samples. [4]
Shown in lab studies on ex vivo human eyelid skin samples (42, 59, 84 yr) by measuring key senescence and aging biomarker, CDKN2A, and a key inflammation biomarker, IL-8. Skin treated with OS-01 EYE displayed significant decreases in CDKN2A and IL-8 compared to skin with no treatment.
Shown in lab studies on ex vivo human eyelid skin samples (42, 59, 84 yr) by measuring key senescence and aging biomarker, CDKN2A, and a key inflammation biomarker, IL-8. Skin treated with OS-01 EYE displayed significant decreases in CDKN2A and IL-8 compared to skin with no treatment.
This means that OS-01 EYE can help mitigate senescence at the molecular level. The result: visible improvements in the skin around your eyes. In a 12 week clincial study, OS-01 EYE improved skin hydration, easlticity, barrier function, and firmness. [4]
This means that OS-01 EYE can help mitigate senescence at the molecular level. The result: visible improvements in the skin around your eyes. In a 12 week clincial study, OS-01 EYE improved skin hydration, easlticity, barrier function, and firmness. [4]
Related Products
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Key Takeaways:
- Periocular skin shows signs of higher cellular senescence than other areas of the face.
- Cellular senescence is a central driver of skin aging.
- The OS-01 peptide has been proven to reduce cellular senescence in lab studies on in vitro human skin. [3,4]
- Formulated with the highest concentration of the OS-01 peptide, our OS-01 EYE Topical Supplement has been shown to decrease CDKN2A, a key marker associated with senescence.
- OS-01 EYE has also been shown to improve elasticity, hydration, barrier function, and firmness. [4]
Key Takeaways:
- Periocular skin shows signs of higher cellular senescence than other areas of the face.
- Cellular senescence is a central driver of skin aging.
- The OS-01 peptide has been proven to reduce cellular senescence in lab studies on in vitro human skin. [3,4]
- Formulated with the highest concentration of the OS-01 peptide, our OS-01 EYE Topical Supplement has been shown to decrease CDKN2A, a key marker associated with senescence.
- OS-01 EYE has also been shown to improve elasticity, hydration, barrier function, and firmness. [4]
References
- https://www.nature.com/articles/35036093
- https://doi.org/10.1016/j.jaad.2016.02.112
- https://www.nature.com/articles/s41514-023-00109-1
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
References
- https://www.nature.com/articles/35036093
- https://doi.org/10.1016/j.jaad.2016.02.112
- https://www.nature.com/articles/s41514-023-00109-1
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
Petrolatum: Is it Safe or Harmful for Your Skin?
How Much Sunscreen to Apply
What Do Antioxidants Do For Skin and Why Should Yo...
Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
PREP enhances the effects of OS-01 FACE, and the p...
Why Skin Barrier is Important
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Ceramides For Skin: Everything You Need to Know ne...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
How to Prevent Skin Aging Before It Starts
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging