FACE LONGEVITY DEFENSE DUO
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An essential skin longevity system for your most UV-exposed skin, built to support collagen and barrier strength.
Protect collagen, build barrier resilience, and boost visible firmness and with OS-01 FACE Moisturizer
Reverse the visible signs of UV aging and protect against future exposure with OS-01 FACE SPF 30+
Dermatologist tested, fragrance-free, suitable for sensitive skin
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Limited Edition OneSkin Bag
OS-01 FACE MOISTURIZER
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OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++
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A complete system built to protect collagen and future-proof skin
The OS-01 Peptide™
Engineered to address cellular senescence, a leading driver of visible skin aging
Non-nano zinc oxide
Protects against UV aging and damage with mineral broad spectrum SPF 30+ defense
5 potent antioxidants
Combat oxidative aging from environmental stress
How it works
Powered by the OS-01 Senescence Peptide™
Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.
FACE LONGEVITY DEFENSE DUO
- RORhonda O.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 4 out of 5 stars18 hours agoGood protection
This sunscreen worked well for me. The color is perfect and I have been using it every day.
OneSkin53 minutes agoHi Rhonda! Thank you so much for your wonderful 4-star feedback about OS-01 FACE SPF! We're absolutely thrilled to hear that it's working well for you and that you've found the perfect color match - that kind of daily satisfaction with our broad spectrum protection really means the world to all of us at OneSkin!
The fact that you're using it every day shows exactly the kind of consistent protection routine we hoped you'd develop with our science-backed approach to UV defense. We love that you've experienced such great results with both the protection and the cosmetic feel!
Thank you for taking the time to share your encouraging feedback about your OS-01 FACE SPF experience - your 4-star review truly means so much to us!
- HBHeidi B.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 starsYesterdayFace tint
I love the way that this product absolutely melts into my skin and the way that my skin has a natural glow.
- MTMeghan T.Verified ReviewerReviewingFACE LONGEVITY DEFENSE DUOI recommend this productRated 5 out of 5 stars2 days agoSo far so good
I have been using both a week and really like the face moisturizer and eye cream. I had a bad experience with it the spf and it made me break out terribly but one skin was fast with the refund. I recommend this product. I’m glad they sent a free mini travel pack that allowed me to try the face wash and eye cream as I will now be purchasing. The smell is a little different but I much prefer it over perfumes so many brands use.
- JJJohn J. B.Verified BuyerReviewingOS-01 FACE Topical Supplement RefillI recommend this productRated 5 out of 5 stars3 days agoExcellent Product
We live in Utah, in which the altitude and proximity to the sun is a factor. This stuff is amazing; once at night, once in the AM and we’re set!
- CHCharles H.Verified BuyerReviewingOS-01 FACE Topical Supplement RefillI recommend this productRated 5 out of 5 stars4 days agoGreat product
Goes on easy and moisturizes really well
Full ingredient list
OS-01 FACE Moisturizer
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
OS-01 FACE SPF
Active Ingredients: Zinc Oxide 17.5%
Inactive ingredients (all tints): Water (Aqua), Caprylic/Capric Triglyceride, Glycerin, Methyl Dihydroabietate, Cetearyl Alcohol, Cetyl Palmitate, Coco-Glucoside, Caprylyl/Capryl Glucoside, Sorbitan Palmitate, Sorbitan Olivate, Butyrospermum Parkii (Shea) Nut Extract, Ethyl Ferulate, Bisabolol, Allantoin, Hydrolyzed Jojoba Esters, Acacia Senegal Gum, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Decapeptide-52*, Oryza Sativa (Rice) Starch, Camellia Sinensis Leaf Extract, Euterpe Oleracea Fruit Extract, Caesalpinia Spinosa Fruit Pod Extract, Helianthus Annuus (Sunflower) Sprout Extract, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Xanthan Gum, Sodium Phytate, Propylene Glycol, Citric Acid, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Triethoxycaprylylsilane, Iron Oxides (CI 77491, CI 77492, CI 77499). *OS-01 Peptide
Drug Facts
Active Ingredients: Zinc Oxide 17.5% …………Purpose: Sunscreen
Uses
Helps prevent sunburn
If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.
Warnings
For external use only.
Do not use on damaged or broken skin.
When using this product keep out of eyes. Rinse with water to remove.
Stop use and ask a doctor if rash occurs.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Citations
01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
