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Body

OS-01 BODY Topical Supplement

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  • Suited to All skin types, safe for sensitive skin
  • Format Nourishing moisturizer
  • Targets Crepiness, dehydration, skin barrier function

OS-01 BODY is a restorative skin longevity treatment powered by the OS-01 Senescence Blocking Peptide™, designed to strengthen the skin barrier, improve hydration, and promote firm, resilient skin from the neck down.01

OneSkin

BENEFITS

Nourishing body moisturizer and targeted treatment for thin, crepey skin

Smooth texture

Improves the root cause of crepey skin by supporting epidermal thickness for a firmer look and feel.01

Deep hydration

Replenishes and locks in hydration to keep skin soft, plump, and nourished.01

Barrier support

Fortifies the skin barrier to protect against daily stressors and moisture loss.01

5-STAR REVIEWS

See why customers love OS-01 BODY

“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.

"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.


"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.

CLINICAL DATA

Visible results, scientifically validated

93

of participants reported improved hydration 01

72

of participants reported improved appearance 01

70

of participants reported improved texture 01

41

Improvement in skin barrier function was measured 01

The Science Behind OS-01 BODY

Your skin is your largest organ and plays a vital role in your overall health as you age. Over time, it becomes thinner, more fragile, and less effective at protecting you from external aggressors. While most skincare focuses on the face, the other 97% of your skin is just as essential for longevity and well-being. OS-01 BODY is designed to strengthen your skin barrier from the neck down, keeping it resilient.

To evaluate OS-01 BODY’s effectiveness, our scientists measured epidermal thickness—a key indicator of barrier strength—using human skin samples in the lab. Results showed a 40% increase in epidermal thickness compared to untreated skin. This aligns with clinical findings demonstrating OS-01 BODY enhances skin barrier function by up to 41.49%.01


Shown in lab studies on ex vivo human skin samples by measuring epidermal thickness of histology images. Skin treated with OS-01 BODY displayed a significant average increase of +40% compared to skin with no treatment. Data was measured in triplicate.

Getting started with OS-01 BODY

Follow these easy steps for optimal results

  • Apply to arms, legs, chest, back, and stomach
  • Massage until absorbed
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Peptide™

The first and only peptide scientifically proven to reverse skin’s biological age.02,03

All Ingredients

Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

Citations

01Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

02Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

03Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

OS-01 BODY Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 2,361 reviews
Total 5 star reviews: 1.9k Total 4 star reviews: 326 Total 3 star reviews: 102 Total 2 star reviews: 24 Total 1 star reviews: 33
93%would recommend these products
Rating
Ratings
2,361 reviews
  • Janet V.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    It actually works

    I have tried every cream possible to get rid of my scaly dry skin on my legs. This is the only cream that has finally worked. After a month of using my skin is unbelievably smooth. Try it you won’t be disappointed.

  • Dyan M.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    Love!

    Love this product. So luxurious. Not too thin or thick. and you don't need a lot. Feels so good and the best part it works! I haven't had my dry legs look this good in a long time. Even my hubby commented on it. My legs feel and look so much smoother. Putting it on my arms next.

  • Elise B.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    So far so good!

    I've only been using the OS-01 Topical Supplement for about 2 1/2 weeks. It goes on easily and spreads nicely. Some topicals take more product to spread evenly, but this one is the perfect consistency to get good coverage with just a few pumps for my whole lower body, and just a couple more for the rest. Excited to keep using and see some changes in my skin!

  • Jeanne t.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    Seeing Improvements

    I have been using the Oneskin body lotion on my arms twice a day and am seeing improvements in texture already. Really appreciate the science behind these products and look forward to seeing more improvements.

  • Dawn
    Verified Reviewer
    Reviewing
    OS-01 BODY Topical Supplement, 250ml
    Rated 3 out of 5 stars
    Feels good

    Feels good but I ordered it because someone on YouTube said it helped with sagging underarms (batwings). I have not seen any difference.

    OneSkin
    Yesterday

    Hi Dawn!

    Thank you for the review!

    To date, it has been well-tolerated by our customers, but we are all unique and can experience changes in routine differently. Results can vary from person to person and can be affected by many things such as genetics, diet, exercise, age, environmental factors, etc. Another thing we'd like to note is while results may not be seen externally, there are many benefits from our peptides that work internally to help the skin.
     
    To start, could you please advise on the following at your convenience:  

    1. Sometimes in different climates, our skin can become drier than normal so you can try adding an additional moisturizer after OS-01 to boost the amount of moisture your skin is receiving.
    2. Try only using OneSkin products in your routine for a few weeks to see if you notice any changes!

    Feel free to reach out to support@oneskin.co for more personalized advice!