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Navigating Skin Longevity: The Industry, The Science, And The Products

Navigating Skin Longevity: The Industry, The Science, And The Products
Getting older is a privilege. Every wrinkle, grey hair, and spot is a sign of all the years you’ve lived and the memories you’ve made. Yet, in a society captivated by youth, the natural marks of aging are often treated as flaws to β€œfix.” With the global β€œanti-aging” industry projected to top $60 billion by 2026, we’re all spending some serious cash to stay young.[1] With so many optionsβ€”Botox, fillers, miracle creamsβ€”it can be challenging to separate genuine innovation from marketing hype.At OneSkin, we take a fresh perspective on aging. Aging is a joyful experience worth embracing, but it's even better when you're in control. Instead of merely chasing youth, we invest in understanding and enhancing skin longevity to prevent age-related decline and help people live longer lives in good health. Ready to redefine how you see aging? Let’s dive into a science-backed approach to skin health that celebrates aging and puts you in control at every phase of life.
Getting older is a privilege. Every wrinkle, grey hair, and spot is a sign of all the years you’ve lived and the memories you’ve made. Yet, in a society captivated by youth, the natural marks of aging are often treated as flaws to β€œfix.” With the global β€œanti-aging” industry projected to top $60 billion by 2026, we’re all spending some serious cash to stay young.[1] With so many optionsβ€”Botox, fillers, miracle creamsβ€”it can be challenging to separate genuine innovation from marketing hype.At OneSkin, we take a fresh perspective on aging. Aging is a joyful experience worth embracing, but it's even better when you're in control. Instead of merely chasing youth, we invest in understanding and enhancing skin longevity to prevent age-related decline and help people live longer lives in good health. Ready to redefine how you see aging? Let’s dive into a science-backed approach to skin health that celebrates aging and puts you in control at every phase of life.
01

What Causes Skin Aging?

Skin ages in two different ways: through intrinsic and extrinsic mechanisms.
  • Intrinsic aging: This is the body’s natural biological aging process, largely controlled by genetics. Over time, your skin gradually accumulates senescent cells, and natural processes like cellular repair begin to slow. This causes your body to produce less vital proteins like collagen and elastin and become less efficient at repairing cellular damage. These physical changes are responsible for the visible signs of aging, like wrinkles or hyperpigmentation.[2]
  • Extrinsic aging: Caused by environmental factors, extrinsic aging expedites the aging your skin naturally experiences. UV exposure is a primary culprit behind extrinsic aging, accounting for up to 80% of the visible signs of skin aging. However, there are a wide variety of contributing factors.[3]

What Factors Influence Skin Aging?

The ways your skin ages are as unique as you are. Here are some of the primary factors:
  • Biological Sex: Skin structure is similar for everyone, but sex hormones and how they change with age play a unique role in how skin ages. During menopause, shifts in a number of these hormones, like estrogen and progesterone, can affect skin thickness and cause collagen levels to plummet. In addition, men often have thicker skin, which can help retain firmness longer.[4]
  • Skin Type: There is a huge range of skin types and tones that all age differently from one another. Whether it's the level of sebum your skin produces or melanin density, there is a strong correlation between skin type and extrinsic aging. For instance, people with darker, melanin-rich skin are less susceptible to skin damage, skin aging, and skin cancer because melanin dissipates UV radiation from the sun.[5,6]
  • Diet: Skin health is closely linked to nutrition. By allowing your skin to maintain its barrier function, a diet high in protein, nutrients, and healthy fats helps it retain hydration. A diet rich in antioxidants can even directly prevent oxidative stress responsible for skin aging. On the other hand, a diet high in processed sugars has been linked to elevated levels of skin inflammation, a hallmark of skin aging.[7]
  • Lifestyle and Health: Little choices add up. Studies have shown, for instance, that a single glass of red wine at dinner can benefit longevity due to its anti-inflammatory and antioxidant properties. However, excessive alcohol consumption has been found to decrease skin barrier function, alter the lipid composition of the skin, and cause noticeable changes in facial skin integrity.[8,9] Similarly, smoking has been found to decrease epidermal thickness, alter skin pigmentation, and increase your risk of skin cancer. Smoking reduces your ability to synthesize the two most important types of skin collagen, types I and III, by around 20%.[10]
  • Environment and Pollution: Your skin is the first line of defense against external contaminants. Studies have shown that ozone created by cars, refineries, and chemical plants activates a class of skin enzymes called metalloproteinases (MMPs) that break down collagen and accelerate aging.[11]
01

What Causes Skin Aging?

Skin ages in two different ways: through intrinsic and extrinsic mechanisms.
  • Intrinsic aging: This is the body’s natural biological aging process, largely controlled by genetics. Over time, your skin gradually accumulates senescent cells, and natural processes like cellular repair begin to slow. This causes your body to produce less vital proteins like collagen and elastin and become less efficient at repairing cellular damage. These physical changes are responsible for the visible signs of aging, like wrinkles or hyperpigmentation.[2]
  • Extrinsic aging: Caused by environmental factors, extrinsic aging expedites the aging your skin naturally experiences. UV exposure is a primary culprit behind extrinsic aging, accounting for up to 80% of the visible signs of skin aging. However, there are a wide variety of contributing factors.[3]

What Factors Influence Skin Aging?

The ways your skin ages are as unique as you are. Here are some of the primary factors:
  • Biological Sex: Skin structure is similar for everyone, but sex hormones and how they change with age play a unique role in how skin ages. During menopause, shifts in a number of these hormones, like estrogen and progesterone, can affect skin thickness and cause collagen levels to plummet. In addition, men often have thicker skin, which can help retain firmness longer.[4]
  • Skin Type: There is a huge range of skin types and tones that all age differently from one another. Whether it's the level of sebum your skin produces or melanin density, there is a strong correlation between skin type and extrinsic aging. For instance, people with darker, melanin-rich skin are less susceptible to skin damage, skin aging, and skin cancer because melanin dissipates UV radiation from the sun.[5,6]
  • Diet: Skin health is closely linked to nutrition. By allowing your skin to maintain its barrier function, a diet high in protein, nutrients, and healthy fats helps it retain hydration. A diet rich in antioxidants can even directly prevent oxidative stress responsible for skin aging. On the other hand, a diet high in processed sugars has been linked to elevated levels of skin inflammation, a hallmark of skin aging.[7]
  • Lifestyle and Health: Little choices add up. Studies have shown, for instance, that a single glass of red wine at dinner can benefit longevity due to its anti-inflammatory and antioxidant properties. However, excessive alcohol consumption has been found to decrease skin barrier function, alter the lipid composition of the skin, and cause noticeable changes in facial skin integrity.[8,9] Similarly, smoking has been found to decrease epidermal thickness, alter skin pigmentation, and increase your risk of skin cancer. Smoking reduces your ability to synthesize the two most important types of skin collagen, types I and III, by around 20%.[10]
  • Environment and Pollution: Your skin is the first line of defense against external contaminants. Studies have shown that ozone created by cars, refineries, and chemical plants activates a class of skin enzymes called metalloproteinases (MMPs) that break down collagen and accelerate aging.[11]
02

What Happens To Your Skin As You Age?

Skin health undergoes significant transitions as you move through each decade, with every phase reflecting changes in cellular and structural dynamics:

Skin Aging In Your 30s

Collagen production and cell turnover in your skin begin to slow in your 20s, although you might not notice any changes until your 30s. As cell turnover slows from roughly every 18 days to once every 28 to 35 days, the skin may begin to dull or appear drier. You might also notice the first signs of sun damage accumulated in your teens and 20s. This includes wrinkles, fine lines, and dryness.[12] Additionally, the accumulation of senescent skin cells tends to begin around 30. However, the aging process likely starts even earlier, as the body becomes less efficient in clearing them away as early as your 20s.[13]
02

What Happens To Your Skin As You Age?

Skin health undergoes significant transitions as you move through each decade, with every phase reflecting changes in cellular and structural dynamics:

Skin Aging In Your 30s

Collagen production and cell turnover in your skin begin to slow in your 20s, although you might not notice any changes until your 30s. As cell turnover slows from roughly every 18 days to once every 28 to 35 days, the skin may begin to dull or appear drier. You might also notice the first signs of sun damage accumulated in your teens and 20s. This includes wrinkles, fine lines, and dryness.[12] Additionally, the accumulation of senescent skin cells tends to begin around 30. However, the aging process likely starts even earlier, as the body becomes less efficient in clearing them away as early as your 20s.[13]

Skin Aging In Your 40s

As collagen and elastin content in the skin continue to decline, your 40s are likely when the visible signs of aging, like skin tone and texture changes, begin to appear. This is also when most women begin to enter perimenopause, accelerating their skin's aging process. Women in perimenopause can experience all sorts of skin issues like increased hyperpigmentation, dryness, and acne.[14]

Skin Aging In Your 40s

As collagen and elastin content in the skin continue to decline, your 40s are likely when the visible signs of aging, like skin tone and texture changes, begin to appear. This is also when most women begin to enter perimenopause, accelerating their skin's aging process. Women in perimenopause can experience all sorts of skin issues like increased hyperpigmentation, dryness, and acne.[14]

Skin Aging In Your 50s and Beyond

As you enter your 50s, you may notice that your skin has become significantly thinner. This is particularly true for post-menopausal women, as studies show that up to 30% of skin collagen can be lost in the 5 years following menopause.[14] Similarly, men enter andropause around their late 40s and early 50s, causing a significant decrease in testosterone production that accelerates the thinning of skin.[15]This era also marks the beginning of bone resorption, the slow degradation of your bones, which can make the skin look less taut and full. At the same time, accumulated UV damage from your 20s, 30s, and 40s can begin to cause more significant wrinkles and crepey skin.

Skin Aging In Your 50s and Beyond

As you enter your 50s, you may notice that your skin has become significantly thinner. This is particularly true for post-menopausal women, as studies show that up to 30% of skin collagen can be lost in the 5 years following menopause.[14] Similarly, men enter andropause around their late 40s and early 50s, causing a significant decrease in testosterone production that accelerates the thinning of skin.[15]This era also marks the beginning of bone resorption, the slow degradation of your bones, which can make the skin look less taut and full. At the same time, accumulated UV damage from your 20s, 30s, and 40s can begin to cause more significant wrinkles and crepey skin.
03

What Skin Longevity Options Are Available To You?

So, how can you take control and keep your skin healthy for years to come? Because the skin care industry is a multi-billion dollar business, the options are near endless. To begin, you’ll need to consider whether you prefer an invasive or non-invasive approach.

Invasive Treatments

Invasive technology penetrates the epidermis to stimulate skin repair and rejuvenation. Generally more expensive than your average skincare product, these in-office procedures often require some downtime for recovery:
  • Laser therapy: Lasers emit high-energy waves that create controlled damage to treat everything from facial wrinkles to hyperpigmentation to acne scarring. Since some types of lasers can cause post-inflammatory hyperpigmentation in darker-skinned individuals, dermatologists specializing in this treatment can recommend the best and safest laser treatment for your concerns. Patients can expect redness and sensitivity for a few days to a month post-procedure.[16]
  • Injections and Fillers: There are a wide variety of injections that enhance the visible appearance of your skin. One of the most common types, dermal fillers, uses hyaluronic acid to help visibly plump and restore lost volume to the skin for at least 6 months. Other microinjections containing hyaluronic acid, vitamins, antioxidants, nutrients, and growth factors have been shown to rejuvenate skin cells and enhance collagen and elastin production.[17,18]
  • Botulinum Toxin (Botox): Botulinum toxin, more commonly known as Botox, is now one of the most popular β€œanti-aging” strategies. Administered via injection, botulinum toxin blocks the release of a neurotransmitter that controls muscle contractions. Botox helps prevent the formation of dynamic wrinkles by preventing specific muscles from contracting. While this can be an effective short-term strategy, Botox will not address the underlying causes of skin aging and can sometimes cause muscle atrophy with repeated use.[19]
  • Microneedling: This procedure uses a device with fine needles that create tiny channels in the skin. These micro-injuries stimulate the skin’s repair process and trigger collagen and elastin production. When combined with topicals like growth factors, hyaluronic acid, or peptides, microneedling can significantly improve skin tone, texture, and resilience. Although immediate downtime is minimal, allowing for a rapid return to daily activities, the microchannels created can take several months to fully heal. This means that repeat treatments should be properly spaced out to avoid complications.[20]
03

What Skin Longevity Options Are Available To You?

So, how can you take control and keep your skin healthy for years to come? Because the skin care industry is a multi-billion dollar business, the options are near endless. To begin, you’ll need to consider whether you prefer an invasive or non-invasive approach.

Invasive Treatments

Invasive technology penetrates the epidermis to stimulate skin repair and rejuvenation. Generally more expensive than your average skincare product, these in-office procedures often require some downtime for recovery:
  • Laser therapy: Lasers emit high-energy waves that create controlled damage to treat everything from facial wrinkles to hyperpigmentation to acne scarring. Since some types of lasers can cause post-inflammatory hyperpigmentation in darker-skinned individuals, dermatologists specializing in this treatment can recommend the best and safest laser treatment for your concerns. Patients can expect redness and sensitivity for a few days to a month post-procedure.[16]
  • Injections and Fillers: There are a wide variety of injections that enhance the visible appearance of your skin. One of the most common types, dermal fillers, uses hyaluronic acid to help visibly plump and restore lost volume to the skin for at least 6 months. Other microinjections containing hyaluronic acid, vitamins, antioxidants, nutrients, and growth factors have been shown to rejuvenate skin cells and enhance collagen and elastin production.[17,18]
  • Botulinum Toxin (Botox): Botulinum toxin, more commonly known as Botox, is now one of the most popular β€œanti-aging” strategies. Administered via injection, botulinum toxin blocks the release of a neurotransmitter that controls muscle contractions. Botox helps prevent the formation of dynamic wrinkles by preventing specific muscles from contracting. While this can be an effective short-term strategy, Botox will not address the underlying causes of skin aging and can sometimes cause muscle atrophy with repeated use.[19]
  • Microneedling: This procedure uses a device with fine needles that create tiny channels in the skin. These micro-injuries stimulate the skin’s repair process and trigger collagen and elastin production. When combined with topicals like growth factors, hyaluronic acid, or peptides, microneedling can significantly improve skin tone, texture, and resilience. Although immediate downtime is minimal, allowing for a rapid return to daily activities, the microchannels created can take several months to fully heal. This means that repeat treatments should be properly spaced out to avoid complications.[20]

Non-Invasive Treatments

On the other end of the spectrum, daily, non-invasive treatments are excellent ways to integrate skin longevity practices into your routine.
  • Daily Habits: Never underestimate the power of daily routines. Your daily actions are some of the most powerful β€œanti-aging” tools at your disposal! A healthy diet and cleansing your face with a gentle cleanser like PREP every night to remove environmental pollutants are essential steps for maintaining skin integrity and texture for the long term.
  • Chemical Peels: Whether used at home or performed in an office, chemical peels encourage cell turnover by removing surface layers of the skin. Benefits include a thicker epidermis, increased collagen production, improved hydration, and reduced hyperpigmentation. Depending on the strength of the treatment, risks can include infection and irritation that can last for several months. Note that only gentle chemical peels should be used at home; medium and deep chemical peels should only be performed under the care of a trained professional.[21,22]
  • UV Protection: Prevention is everything when it comes to keeping your skin young. The sun is the biggest culprit in aging skin, so sunscreen is a mustβ€”even on a cold or cloudy day. Don't just settle for any SPF, though. Look for one like OS-01 FACE SPF or OS-01 BODY SPF that’s 30+ SPF and packed with actives like peptides and antioxidants to combat the effects of skin aging.
  • β€œAnti-Aging” Skin Care & Supplements: Topical skin care is one of the most popular tools for β€œanti-aging.” These products, which typically include ingredients like antioxidants, peptides, or retinoids, help repair and reverse signs of aging.

Non-Invasive Treatments

On the other end of the spectrum, daily, non-invasive treatments are excellent ways to integrate skin longevity practices into your routine.
  • Daily Habits: Never underestimate the power of daily routines. Your daily actions are some of the most powerful β€œanti-aging” tools at your disposal! A healthy diet and cleansing your face with a gentle cleanser like PREP every night to remove environmental pollutants are essential steps for maintaining skin integrity and texture for the long term.
  • Chemical Peels: Whether used at home or performed in an office, chemical peels encourage cell turnover by removing surface layers of the skin. Benefits include a thicker epidermis, increased collagen production, improved hydration, and reduced hyperpigmentation. Depending on the strength of the treatment, risks can include infection and irritation that can last for several months. Note that only gentle chemical peels should be used at home; medium and deep chemical peels should only be performed under the care of a trained professional.[21,22]
  • UV Protection: Prevention is everything when it comes to keeping your skin young. The sun is the biggest culprit in aging skin, so sunscreen is a mustβ€”even on a cold or cloudy day. Don't just settle for any SPF, though. Look for one like OS-01 FACE SPF or OS-01 BODY SPF that’s 30+ SPF and packed with actives like peptides and antioxidants to combat the effects of skin aging.
  • β€œAnti-Aging” Skin Care & Supplements: Topical skin care is one of the most popular tools for β€œanti-aging.” These products, which typically include ingredients like antioxidants, peptides, or retinoids, help repair and reverse signs of aging.
04

How To Choose Which Topical Ingredients To Use?

While skin care can be packed with plenty of ingredients that help your skin feel better, few are genuinely designed to promote your skin's longevity. Here are some of the most common skin longevity-boosting ingredients:
  • Retinoids: Retinoids like retinol and tretinoin have long been considered the gold standard in skin longevity for their ability to boost collagen and smooth out wrinkles by speeding up cell turnover.[23] These results are possible because retinoids encourage rapid cellular division in deeper skin layers. However, they can also be intense on the skin as rapidly produced skin cells are often sub-functional and cause unhealthy peeling and inflammation. In fact, in a study performed by OneSkin scientists, retinol was shown to significantly increase a biomarker linked to aging. You can read more about the research behind retinol here.[24]
  • Niacinamide: Niacinamide, a potent form of Vitamin B3, is widely celebrated for its multi-functional benefits in skincare. This powerhouse ingredient reinforces the skin’s natural barrier, which helps reduce moisture loss, soothe inflammation, and minimize the appearance of pores, making it a favorite for sensitive or reactive skin. One of niacinamide’s most unique qualities is its role as a precursor to NAD+ (nicotinamide adenine dinucleotide), a vital coenzyme that plays a significant role in enhancing cell survival and longevity by aiding cellular metabolism and DNA repair, which are crucial for maintaining youthful, resilient skin.[25,26]
  • Antioxidants: Antioxidants are a must-have in any skin longevity regime that work by neutralizing damaging molecules responsible for skin aging, known as reactive oxygen species (ROS). UV radiation is the leading cause of ROS generation in skin cells, which has been linked to skin inflammation, alterations to skin pigmentation, and reduced synthesis of collagen in the dermal layer. You should incorporate antioxidants into your diet and skin care regimen.[27,28]
  • Hyaluronic acid: That fresh, hydrated glow you have when you’re young? It’s thanks to hyaluronic acid, which keeps skin plump by holding in hydration. The body’s natural stores of hyaluronic acid are mainly found in the extracellular matrix, a system of fibers that maintain skin structure. As you age and accumulate UV damage, hyaluronic acid begins to break down and disappear from your skin. Thankfully, daily topical application has been found to replace lost hyaluronic acid, decrease wrinkle depth, and restore up to a 50% increase in skin tautness.[29,30]
  • Peptides: Peptides are like mini proteins that can have a range of impacts on your cells. Unlike many β€œanti-aging” ingredients, peptides can absorb deep into the skin and some may address the root causes of skin aging. Peptides can act as signaling molecules to help your skin cells function optimally and even intervene in age-related processes like cellular senescence. One of these peptides is OS-01, the breakthrough ingredient behind our topical supplements.
04

How To Choose Which Topical Ingredients To Use?

While skin care can be packed with plenty of ingredients that help your skin feel better, few are genuinely designed to promote your skin's longevity. Here are some of the most common skin longevity-boosting ingredients:
  • Retinoids: Retinoids like retinol and tretinoin have long been considered the gold standard in skin longevity for their ability to boost collagen and smooth out wrinkles by speeding up cell turnover.[23] These results are possible because retinoids encourage rapid cellular division in deeper skin layers. However, they can also be intense on the skin as rapidly produced skin cells are often sub-functional and cause unhealthy peeling and inflammation. In fact, in a study performed by OneSkin scientists, retinol was shown to significantly increase a biomarker linked to aging. You can read more about the research behind retinol here.[24]
  • Niacinamide: Niacinamide, a potent form of Vitamin B3, is widely celebrated for its multi-functional benefits in skincare. This powerhouse ingredient reinforces the skin’s natural barrier, which helps reduce moisture loss, soothe inflammation, and minimize the appearance of pores, making it a favorite for sensitive or reactive skin. One of niacinamide’s most unique qualities is its role as a precursor to NAD+ (nicotinamide adenine dinucleotide), a vital coenzyme that plays a significant role in enhancing cell survival and longevity by aiding cellular metabolism and DNA repair, which are crucial for maintaining youthful, resilient skin.[25,26]
  • Antioxidants: Antioxidants are a must-have in any skin longevity regime that work by neutralizing damaging molecules responsible for skin aging, known as reactive oxygen species (ROS). UV radiation is the leading cause of ROS generation in skin cells, which has been linked to skin inflammation, alterations to skin pigmentation, and reduced synthesis of collagen in the dermal layer. You should incorporate antioxidants into your diet and skin care regimen.[27,28]
  • Hyaluronic acid: That fresh, hydrated glow you have when you’re young? It’s thanks to hyaluronic acid, which keeps skin plump by holding in hydration. The body’s natural stores of hyaluronic acid are mainly found in the extracellular matrix, a system of fibers that maintain skin structure. As you age and accumulate UV damage, hyaluronic acid begins to break down and disappear from your skin. Thankfully, daily topical application has been found to replace lost hyaluronic acid, decrease wrinkle depth, and restore up to a 50% increase in skin tautness.[29,30]
  • Peptides: Peptides are like mini proteins that can have a range of impacts on your cells. Unlike many β€œanti-aging” ingredients, peptides can absorb deep into the skin and some may address the root causes of skin aging. Peptides can act as signaling molecules to help your skin cells function optimally and even intervene in age-related processes like cellular senescence. One of these peptides is OS-01, the breakthrough ingredient behind our topical supplements.
05

How Is OS-01 Different From Other Skin Longevity Treatments?

Unlike other topical ingredients, and even other peptides, OS-01 is the first peptide proven to reverse skin’s biological age by preventing the accumulation of senescent cells. These cells release senescence-associated secretory phenotypes (SASP) that increase inflammation and promote cellular aging in surrounding skin cells. By blocking these SASP signals, OS-01 encourages cellular repair and collagen production, minimizes wrinkles, restores firmness, and visibly brightens hyperpigmentation.[31, 32, 33] Like retinol, OS-01 has been shown to increase biomarkers associated with collagen production. However, whereas retinol increases inflammation and aging biomarkers, OS-01 reduces these markers – all while strengthening skin barrier function and increasing epidermal thickness.[31, 32]To magnify the benefits of OS-01, we’ve combined it with potent antioxidants and best-in-class moisturizing ingredients, giving you the best skin care ingredients in a simple line of topical supplements: OS-01 FACE, OS-01 EYE, and OS-01 BODY. We even included the OS-01 peptide into our sunscreens OS-01 FACE SPF or OS-01 BODY SPF to help you layer your skin protection strategies. With OS-01, we’re pioneering a new approach focused on addressing the root causes of skin aging rather than just the surface-level signs. With it, we hope to inspire a new era where we give you control of your skin, turning the aging process into a privilege, not a problem.
05

How Is OS-01 Different From Other Skin Longevity Treatments?

Unlike other topical ingredients, and even other peptides, OS-01 is the first peptide proven to reverse skin’s biological age by preventing the accumulation of senescent cells. These cells release senescence-associated secretory phenotypes (SASP) that increase inflammation and promote cellular aging in surrounding skin cells. By blocking these SASP signals, OS-01 encourages cellular repair and collagen production, minimizes wrinkles, restores firmness, and visibly brightens hyperpigmentation.[31, 32, 33] Like retinol, OS-01 has been shown to increase biomarkers associated with collagen production. However, whereas retinol increases inflammation and aging biomarkers, OS-01 reduces these markers – all while strengthening skin barrier function and increasing epidermal thickness.[31, 32]To magnify the benefits of OS-01, we’ve combined it with potent antioxidants and best-in-class moisturizing ingredients, giving you the best skin care ingredients in a simple line of topical supplements: OS-01 FACE, OS-01 EYE, and OS-01 BODY. We even included the OS-01 peptide into our sunscreens OS-01 FACE SPF or OS-01 BODY SPF to help you layer your skin protection strategies. With OS-01, we’re pioneering a new approach focused on addressing the root causes of skin aging rather than just the surface-level signs. With it, we hope to inspire a new era where we give you control of your skin, turning the aging process into a privilege, not a problem.
Key Takeaways:
  • Aging is a natural process that signifies growth and experience, deserving respect rather than disdain.
  • Understanding the intrinsic and extrinsic mechanisms of skin aging enables the development of effective interventions and treatments.
  • While invasive skin care procedures can be effective, non-invasive treatments and consistent daily skincare routines are among the most powerful tools for promoting skin longevity.
  • Protecting your skin from environmental damage like UV radiation and pollution can prevent primary sources of visible skin aging.
  • Peptides, like OS-01, represent a new dawn in skincare by rejuvenating and repairing existing skin aging and helping to prevent future skin aging to put you in control of the longevity of your skin.
Key Takeaways:
  • Aging is a natural process that signifies growth and experience, deserving respect rather than disdain.
  • Understanding the intrinsic and extrinsic mechanisms of skin aging enables the development of effective interventions and treatments.
  • While invasive skin care procedures can be effective, non-invasive treatments and consistent daily skincare routines are among the most powerful tools for promoting skin longevity.
  • Protecting your skin from environmental damage like UV radiation and pollution can prevent primary sources of visible skin aging.
  • Peptides, like OS-01, represent a new dawn in skincare by rejuvenating and repairing existing skin aging and helping to prevent future skin aging to put you in control of the longevity of your skin.
Disclaimers
This article was initially published in July 2023 and has been updated.
Disclaimers
This article was initially published in July 2023 and has been updated.
References
  1. https://www.fortunebusinessinsights.com/anti-aging-cosmetics-market-102768
  2. https://pubmed.ncbi.nlm.nih.gov/18377617/
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4344124/
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC6116811/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC2671032/
  6. https://pubmed.ncbi.nlm.nih.gov/15492432/
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC7146365/
  8. https://journals.sagepub.com/doi/abs/10.3181/00379727-166-41110
  9. https://pmc.ncbi.nlm.nih.gov/articles/PMC6668865/
  10. https://pubmed.ncbi.nlm.nih.gov/11966688/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC3583881/
  12. https://pubmed.ncbi.nlm.nih.gov/6827031/
  13. https://onlinelibrary.wiley.com/doi/10.1111/exd.14818
  14. https://pmc.ncbi.nlm.nih.gov/articles/PMC7859014/
  15. https://www.nature.com/articles/3900798
  16. https://www.ncbi.nlm.nih.gov/books/NBK559150/
  17. https://pmc.ncbi.nlm.nih.gov/articles/PMC10413051/
  18. https://pubmed.ncbi.nlm.nih.gov/24810127/
  19. https://pmc.ncbi.nlm.nih.gov/articles/PMC2856357/
  20. https://pmc.ncbi.nlm.nih.gov/articles/PMC4976400/
  21. https://pmc.ncbi.nlm.nih.gov/articles/PMC2921757/
  22. https://www.ncbi.nlm.nih.gov/books/NBK547752/
  23. https://pmc.ncbi.nlm.nih.gov/articles/PMC2699641/
  24. https://www.nature.com/articles/s41514-023-00109-1
  25. https://pubmed.ncbi.nlm.nih.gov/24993939/
  26. https://pubmed.ncbi.nlm.nih.gov/18165311/
  27. https://pmc.ncbi.nlm.nih.gov/articles/PMC5514576/
  28. https://pmc.ncbi.nlm.nih.gov/articles/PMC8776015/
  29. https://pmc.ncbi.nlm.nih.gov/articles/PMC3583886/
  30. https://pmc.ncbi.nlm.nih.gov/articles/PMC3970829/
  31. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
  32. Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024.
  33. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
References
  1. https://www.fortunebusinessinsights.com/anti-aging-cosmetics-market-102768
  2. https://pubmed.ncbi.nlm.nih.gov/18377617/
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4344124/
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC6116811/
  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC2671032/
  6. https://pubmed.ncbi.nlm.nih.gov/15492432/
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC7146365/
  8. https://journals.sagepub.com/doi/abs/10.3181/00379727-166-41110
  9. https://pmc.ncbi.nlm.nih.gov/articles/PMC6668865/
  10. https://pubmed.ncbi.nlm.nih.gov/11966688/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC3583881/
  12. https://pubmed.ncbi.nlm.nih.gov/6827031/
  13. https://onlinelibrary.wiley.com/doi/10.1111/exd.14818
  14. https://pmc.ncbi.nlm.nih.gov/articles/PMC7859014/
  15. https://www.nature.com/articles/3900798
  16. https://www.ncbi.nlm.nih.gov/books/NBK559150/
  17. https://pmc.ncbi.nlm.nih.gov/articles/PMC10413051/
  18. https://pubmed.ncbi.nlm.nih.gov/24810127/
  19. https://pmc.ncbi.nlm.nih.gov/articles/PMC2856357/
  20. https://pmc.ncbi.nlm.nih.gov/articles/PMC4976400/
  21. https://pmc.ncbi.nlm.nih.gov/articles/PMC2921757/
  22. https://www.ncbi.nlm.nih.gov/books/NBK547752/
  23. https://pmc.ncbi.nlm.nih.gov/articles/PMC2699641/
  24. https://www.nature.com/articles/s41514-023-00109-1
  25. https://pubmed.ncbi.nlm.nih.gov/24993939/
  26. https://pubmed.ncbi.nlm.nih.gov/18165311/
  27. https://pmc.ncbi.nlm.nih.gov/articles/PMC5514576/
  28. https://pmc.ncbi.nlm.nih.gov/articles/PMC8776015/
  29. https://pmc.ncbi.nlm.nih.gov/articles/PMC3583886/
  30. https://pmc.ncbi.nlm.nih.gov/articles/PMC3970829/
  31. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
  32. Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024.
  33. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims

Last Updated February 26, 2025

Reviewed by

Alessandra Zonari

Alessandra Zonari

PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.