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Introducing OS-01 BODY SPF: Triple power protection from UV, collagen degradation, and cellular aging

6 min read
May 15,2024
ONESKIN PRODUCTS

Introducing OS-01 BODY SPF: Triple power protection from UV, collagen degradation, and cellular aging

6 min read
May 15,2024
ONESKIN PRODUCTS
Sunscreen isn't just important—it's essential for keeping your skin healthy and radiant. That being said, not all SPFs are created equal. Our new OS-01 BODY SPF isn't just any sunscreen; it’s a major leap in body SPF technology. OS-01 FACE SPF and OS-01 BODY SPF
not only prevent sun-damaged skin, but they can also target existing skin aging with the OS-01 Senescence Blocking PeptideTM. (1,2)
Sunscreen isn't just important—it's essential for keeping your skin healthy and radiant. That being said, not all SPFs are created equal. Our new OS-01 BODY SPF isn't just any sunscreen; it’s a major leap in body SPF technology. OS-01 FACE SPF and OS-01 BODY SPF
not only prevent sun-damaged skin, but they can also target existing skin aging with the OS-01 Senescence Blocking PeptideTM. (1,2)
01

Science-Driven Skincare

At the heart of OS-01 BODY SPF lies a deep commitment to scientific rigor and evidence-based formulation. Like all OneSkin products, this sunscreen was born in the OneSkin lab, where our team of dedicated researchers refined its unique blend of active ingredients. Together with the OS-01 FACE SPF (formerly OS-01 SHIELD), these two sunscreens represent a groundbreaking advancement in the field of sun protection. When used in conjunction with our OS-01 topical supplements, you can experience the maximum benefits of this innovative peptide and start to see your skin looking and behaving like its younger self.

OS-01 BODY SPF Protects Skin From UV-induced Collagen Degradation

With broad-spectrum SPF 30+ and PA+++, OS-01 BODY SPF blocks out more than 97 percent of harmful UVB rays (see why a higher SPF isn’t necessarily better here). Our broad-spectrum formula protects your skin from the kind of UV damage that can degrade collagen and accelerate aging. Keep in mind that sun damage is the number one cause of skin aging. (3)OneSkin scientists treated ex vivo human skin samples with OS-01 BODY SPF and exposed these samples to UVB radiation to measure collagen density against a control sample. This three-color dye procedure, known as Masson's Trichrome staining, displays collagen (blue), nuclei (dark brown), muscle tissue (red), and cytoplasm (pink).
01

Science-Driven Skincare

At the heart of OS-01 BODY SPF lies a deep commitment to scientific rigor and evidence-based formulation. Like all OneSkin products, this sunscreen was born in the OneSkin lab, where our team of dedicated researchers refined its unique blend of active ingredients. Together with the OS-01 FACE SPF (formerly OS-01 SHIELD), these two sunscreens represent a groundbreaking advancement in the field of sun protection. When used in conjunction with our OS-01 topical supplements, you can experience the maximum benefits of this innovative peptide and start to see your skin looking and behaving like its younger self.

OS-01 BODY SPF Protects Skin From UV-induced Collagen Degradation

With broad-spectrum SPF 30+ and PA+++, OS-01 BODY SPF blocks out more than 97 percent of harmful UVB rays (see why a higher SPF isn’t necessarily better here). Our broad-spectrum formula protects your skin from the kind of UV damage that can degrade collagen and accelerate aging. Keep in mind that sun damage is the number one cause of skin aging. (3)OneSkin scientists treated ex vivo human skin samples with OS-01 BODY SPF and exposed these samples to UVB radiation to measure collagen density against a control sample. This three-color dye procedure, known as Masson's Trichrome staining, displays collagen (blue), nuclei (dark brown), muscle tissue (red), and cytoplasm (pink).
Representative histological images of ex vivo human skin samples (59y) that were treated with nothing (No Treatment) or OS-01 BODY SPF with and without 1J/cm2 UVB radiation and stained with Masson’s Trichrome after 24hrs.
Upon examination under the microscope, the scientists observed that the skin treated with OS-01 BODY SPF displayed a more cohesive stratum corneum and an increased collagen density, as indicated by the deeper blue color in the epidermis even after exposure to UVB radiation. When they quantified the collagen density results, the data revealed that OS-01 BODY SPF effectively protected the skin from this collagen degradation, unlike the benchmark SPF. By protecting your skin from this radiation, OS-01 BODY SPF helps prevent the visible signs of UV aging.
Representative histological images of ex vivo human skin samples (59y) that were treated with nothing (No Treatment) or OS-01 BODY SPF with and without 1J/cm2 UVB radiation and stained with Masson’s Trichrome after 24hrs.
Upon examination under the microscope, the scientists observed that the skin treated with OS-01 BODY SPF displayed a more cohesive stratum corneum and an increased collagen density, as indicated by the deeper blue color in the epidermis even after exposure to UVB radiation. When they quantified the collagen density results, the data revealed that OS-01 BODY SPF effectively protected the skin from this collagen degradation, unlike the benchmark SPF. By protecting your skin from this radiation, OS-01 BODY SPF helps prevent the visible signs of UV aging.
Ex vivo
human skin samples that were treated with nothing (No Treatment) or OS-01 BODY SPF were exposed to 1J/cm2 UVB radiation and collagen density was analyzed after 24 hours using Masson’s Trichrome staining.
Ex vivo
human skin samples that were treated with nothing (No Treatment) or OS-01 BODY SPF were exposed to 1J/cm2 UVB radiation and collagen density was analyzed after 24 hours using Masson’s Trichrome staining.

OS-01 BODY SPF Reduces the Effects of UV Aging

While the damaging effects of UV radiation on the skin are well-documented, the story of skin aging is complex. Skin aging involves both extrinsic and intrinsic factors. Extrinsic aging accelerators include UV radiation and other environmental exposures. Intrinsic aging includes increased levels of senescence and inflammation. Along with the breakdown of essential skin components like collagen and hyaluronic acid, skin aging is a physical process within the skin that is accelerated by UV exposure.To better understand how OS-01 BODY SPF mitigates skin aging, we compared the gene expression levels of key biomarkers associated with aging and skin deterioration of ex vivo human skin samples treated with OS-01 BODY SPF against a control. The results showed that OS-01 BODY SPF decreased the levels of key biomarkers associated with the aging process and cellular senescence. Specifically, the product was shown to reduce the expression of p16, a marker of cellular senescence, as well as IL-8, a pro-inflammatory cytokine. Additionally, OS-01 BODY SPF was found to mitigate the degradation of hyaluronic acid (as indicated by lower HYAL1 levels) and collagen (as shown by decreased MMP-1 levels).

OS-01 BODY SPF Reduces the Effects of UV Aging

While the damaging effects of UV radiation on the skin are well-documented, the story of skin aging is complex. Skin aging involves both extrinsic and intrinsic factors. Extrinsic aging accelerators include UV radiation and other environmental exposures. Intrinsic aging includes increased levels of senescence and inflammation. Along with the breakdown of essential skin components like collagen and hyaluronic acid, skin aging is a physical process within the skin that is accelerated by UV exposure.To better understand how OS-01 BODY SPF mitigates skin aging, we compared the gene expression levels of key biomarkers associated with aging and skin deterioration of ex vivo human skin samples treated with OS-01 BODY SPF against a control. The results showed that OS-01 BODY SPF decreased the levels of key biomarkers associated with the aging process and cellular senescence. Specifically, the product was shown to reduce the expression of p16, a marker of cellular senescence, as well as IL-8, a pro-inflammatory cytokine. Additionally, OS-01 BODY SPF was found to mitigate the degradation of hyaluronic acid (as indicated by lower HYAL1 levels) and collagen (as shown by decreased MMP-1 levels).
Ex vivo human skin samples (41y and 59y) that were treated with nothing (No Treatment) or OS-01 BODY SPF were exposed to 1J/cm2 UVB radiation, then the gene expression levels were analyzed after 24 hours.
This comprehensive data demonstrates that the formulation of OS-01 BODY SPF, which contains non-nano zinc oxide, the OS-01 peptide, and a blend of potent antioxidants, can effectively help reduce the detrimental effects of UV exposure on skin aging. By targeting multiple pathways involved in both intrinsic and extrinsic skin aging, this innovative sunscreen offers a multi-pronged approach to preserving the health and youthful appearance of the skin.
Ex vivo human skin samples (41y and 59y) that were treated with nothing (No Treatment) or OS-01 BODY SPF were exposed to 1J/cm2 UVB radiation, then the gene expression levels were analyzed after 24 hours.
This comprehensive data demonstrates that the formulation of OS-01 BODY SPF, which contains non-nano zinc oxide, the OS-01 peptide, and a blend of potent antioxidants, can effectively help reduce the detrimental effects of UV exposure on skin aging. By targeting multiple pathways involved in both intrinsic and extrinsic skin aging, this innovative sunscreen offers a multi-pronged approach to preserving the health and youthful appearance of the skin.

OS-01 BODY SPF Offers Superior Antioxidant Power

While UV radiation is undoubtedly the biggest extrinsic skin aging factor, it's not the only culprit. Ionizing radiation (IR), blue light (HEV light), and pollution are all known to generate free radicals, unstable molecules that have one or more unpaired electrons. (4) These free radicals wreak havoc in the skin damaging DNA and proteins leading to more visible signs of skin aging. Luckily these free radicals can be neutralized by antioxidants in your diet and skincare. To ensure that OS-01 BODY SPF covers the multifaceted assault on skin health, our formula is infused with a blend of potent antioxidants like vitamin C, green tea, acai, and tara fruit extracts. To test how well these antioxidants work to neutralize free radicals, our scientists put OS-01 BODY SPF to the test, comparing its antioxidant capacity against strong antioxidants like green tea oil and commonly used "anti-aging" SPFs that contain antioxidants.

OS-01 BODY SPF Offers Superior Antioxidant Power

While UV radiation is undoubtedly the biggest extrinsic skin aging factor, it's not the only culprit. Ionizing radiation (IR), blue light (HEV light), and pollution are all known to generate free radicals, unstable molecules that have one or more unpaired electrons. (4) These free radicals wreak havoc in the skin damaging DNA and proteins leading to more visible signs of skin aging. Luckily these free radicals can be neutralized by antioxidants in your diet and skincare. To ensure that OS-01 BODY SPF covers the multifaceted assault on skin health, our formula is infused with a blend of potent antioxidants like vitamin C, green tea, acai, and tara fruit extracts. To test how well these antioxidants work to neutralize free radicals, our scientists put OS-01 BODY SPF to the test, comparing its antioxidant capacity against strong antioxidants like green tea oil and commonly used "anti-aging" SPFs that contain antioxidants.
Antioxidant capacity was measured using a DPPH assay. n=4
The results were impressive. Compared to other "anti-aging" SPFs, OS-01 BODY SPF exhibited superior antioxidant capacity. OS-01 BODY SPF performed exceptionally well matching green tea oil, an extremely strong antioxidant. The carefully curated blend of antioxidants in OS-01 BODY SPF can effectively neutralize free radicals and minimize their damaging effects on the skin.
Antioxidant capacity was measured using a DPPH assay. n=4
The results were impressive. Compared to other "anti-aging" SPFs, OS-01 BODY SPF exhibited superior antioxidant capacity. OS-01 BODY SPF performed exceptionally well matching green tea oil, an extremely strong antioxidant. The carefully curated blend of antioxidants in OS-01 BODY SPF can effectively neutralize free radicals and minimize their damaging effects on the skin.
02

How Does OS-01 BODY SPF Do It?

What sets the OS-01 BODY SPF apart is its use of our exclusive OS-01 peptide, which targets the very core of skin aging. This means you're not just shielding your skin on the surface—you're also slowing aging at the cellular level, addressing both intrinsic and extrinsic aging.
02

How Does OS-01 BODY SPF Do It?

What sets the OS-01 BODY SPF apart is its use of our exclusive OS-01 peptide, which targets the very core of skin aging. This means you're not just shielding your skin on the surface—you're also slowing aging at the cellular level, addressing both intrinsic and extrinsic aging.
Adapted from Naylor EC, Watson RE, Sherratt MJ. Molecular aspects of skin ageing. Maturitas. 2011 Jul;69(3):249-56. doi: 10.1016/j.maturitas.2011.04.011.
Intrinsic aging:Intrinsic aging happens over time, central to which is cellular senescence. This is where the OS-01 peptide comes into play. As the first body SPF to be formulated with this cutting-edge compound, OS-01 BODY SPF is designed to target a key driver of intrinsic skin aging, helping to slow the process at the cellular level. Extrinsic aging:On the other hand, to tackle extrinsic aging, OS-01 BODY SPF utilizes non-nano zinc oxide to provide broad-spectrum protection against UVA and UVB rays, as well as a blend of potent antioxidants to help neutralize the free radicals that can be generated by exposure to blue light, infrared radiation, and pollution. This protects the skin from various aging accelerators.
  • Pollution. Exposure to pollutants increases ROS and inflammation, exacerbating photoaging and leading to a more aged appearance. (5)
  • Chronic infrared radiation. Exposure can generate free radicals and ROS by penetrating the dermis, degrading proteins like collagen, and contributing to premature skin aging. (6)
  • Visible light. Up to half of free radicals produced in skin may be due to visible light, including blue light emitted by electronic screens - high doses and chronic exposure can generate damaging free radicals, though low doses may have some benefits for skin conditions. (7)
Adapted from Naylor EC, Watson RE, Sherratt MJ. Molecular aspects of skin ageing. Maturitas. 2011 Jul;69(3):249-56. doi: 10.1016/j.maturitas.2011.04.011.
Intrinsic aging:Intrinsic aging happens over time, central to which is cellular senescence. This is where the OS-01 peptide comes into play. As the first body SPF to be formulated with this cutting-edge compound, OS-01 BODY SPF is designed to target a key driver of intrinsic skin aging, helping to slow the process at the cellular level. Extrinsic aging:On the other hand, to tackle extrinsic aging, OS-01 BODY SPF utilizes non-nano zinc oxide to provide broad-spectrum protection against UVA and UVB rays, as well as a blend of potent antioxidants to help neutralize the free radicals that can be generated by exposure to blue light, infrared radiation, and pollution. This protects the skin from various aging accelerators.
  • Pollution. Exposure to pollutants increases ROS and inflammation, exacerbating photoaging and leading to a more aged appearance. (5)
  • Chronic infrared radiation. Exposure can generate free radicals and ROS by penetrating the dermis, degrading proteins like collagen, and contributing to premature skin aging. (6)
  • Visible light. Up to half of free radicals produced in skin may be due to visible light, including blue light emitted by electronic screens - high doses and chronic exposure can generate damaging free radicals, though low doses may have some benefits for skin conditions. (7)
03

Usability and Skin Compatibility

When choosing a UV filter, we opted for non-nano zinc oxide, as current data suggests it presents the lowest risk of health effects and the maximum broad spectrum protection compared to other chemical and mineral alternatives. However, non-nano mineral sunscreens are criticized for their chalky, gritty texture and the unsightly white cast they can leave on the skin due to the large size of particles. OS-01 BODY SPF, however, was designed to be lightweight, absorb quickly, and blend seamlessly.To ensure that OS-01 BODY SPF not only provides exceptional benefits to the skin but also an excellent experience when you apply it, our team conducted a one-week beta test with 30 randomly selected participants. The results were overwhelmingly positive:
  • 100% of users agreed that OS-01 BODY SPF applied evenly and smoothly.
  • 96.7% of users agreed that the product felt light and weightless on their skin.
  • 93.3% of users, comprising skin tones from Type I to Type VI, agreed that the product blended seamlessly with their skin tone.
Moreover, zinc oxide is known to be suitable for all skin types, including sensitive, oily, acne-prone, and dry skin. Its anti-inflammatory properties make it beneficial for those with inflammatory skin conditions, while its antibacterial qualities can help control oil production and reduce secondary infections associated with acne. (8)For those with dry skin, the protective barrier created by zinc oxide can help prevent transepidermal water loss, which becomes increasingly important as we age and the skin's natural ability to regulate moisture decreases. When used in conjunction with the OS-01 topical supplements - OS-01 FACE, BODY, and EYE - users can experience the maximum benefits of the OS-01 peptide.
03

Usability and Skin Compatibility

When choosing a UV filter, we opted for non-nano zinc oxide, as current data suggests it presents the lowest risk of health effects and the maximum broad spectrum protection compared to other chemical and mineral alternatives. However, non-nano mineral sunscreens are criticized for their chalky, gritty texture and the unsightly white cast they can leave on the skin due to the large size of particles. OS-01 BODY SPF, however, was designed to be lightweight, absorb quickly, and blend seamlessly.To ensure that OS-01 BODY SPF not only provides exceptional benefits to the skin but also an excellent experience when you apply it, our team conducted a one-week beta test with 30 randomly selected participants. The results were overwhelmingly positive:
  • 100% of users agreed that OS-01 BODY SPF applied evenly and smoothly.
  • 96.7% of users agreed that the product felt light and weightless on their skin.
  • 93.3% of users, comprising skin tones from Type I to Type VI, agreed that the product blended seamlessly with their skin tone.
Moreover, zinc oxide is known to be suitable for all skin types, including sensitive, oily, acne-prone, and dry skin. Its anti-inflammatory properties make it beneficial for those with inflammatory skin conditions, while its antibacterial qualities can help control oil production and reduce secondary infections associated with acne. (8)For those with dry skin, the protective barrier created by zinc oxide can help prevent transepidermal water loss, which becomes increasingly important as we age and the skin's natural ability to regulate moisture decreases. When used in conjunction with the OS-01 topical supplements - OS-01 FACE, BODY, and EYE - users can experience the maximum benefits of the OS-01 peptide.
04

Conclusion

With its unique blend of non-nano zinc oxide, the OS-01 peptide, and a potent antioxidant complex, OS-01 BODY SPF offers triple-power protection that’s scientifically proven to deliver real results. Whether you're looking to maintain the radiance and resilience of youthful skin or reverse the visible signs of premature aging, this transformative product is poised to become an essential part of your skincare routine.
04

Conclusion

With its unique blend of non-nano zinc oxide, the OS-01 peptide, and a potent antioxidant complex, OS-01 BODY SPF offers triple-power protection that’s scientifically proven to deliver real results. Whether you're looking to maintain the radiance and resilience of youthful skin or reverse the visible signs of premature aging, this transformative product is poised to become an essential part of your skincare routine.
Key Takeaways:
  • OS-01 BODY SPF provides broad-spectrum SPF 30+ and PA+++ protection, blocking over 90% of harmful UV rays. It not only protects but also reverses signs of aging by increasing collagen density even after UV exposure.
  • The OS-01 BODY SPF has been shown to decrease the expression of key biomarkers associated with aging and cellular senescence in treated skin samples.
  • Infused with a potent mix of antioxidants like Vitamin C and Green Tea, OS-01 BODY SPF exhibits superior antioxidant capacity compared to traditional "anti-aging" sunscreens, effectively neutralizing free radicals that contribute to skin aging.
  • OS-01 BODY SPF targets intrinsic aging at the cellular level with its OS-01 peptide and combats extrinsic aging factors through broad-spectrum UV protection and antioxidants.
  • Designed to be lightweight and blend seamlessly without the typical chalky texture or white cast associated with mineral sunscreens, OS-01 BODY SPF has been well-received by users across various skin tones, demonstrating high usability and compatibility.
  • The formulation offers triple-action protection from UV rays, collagen degradation, and cellular aging, making it a cutting-edge solution for maintaining youthful skin and reversing signs of aging.
Key Takeaways:
  • OS-01 BODY SPF provides broad-spectrum SPF 30+ and PA+++ protection, blocking over 90% of harmful UV rays. It not only protects but also reverses signs of aging by increasing collagen density even after UV exposure.
  • The OS-01 BODY SPF has been shown to decrease the expression of key biomarkers associated with aging and cellular senescence in treated skin samples.
  • Infused with a potent mix of antioxidants like Vitamin C and Green Tea, OS-01 BODY SPF exhibits superior antioxidant capacity compared to traditional "anti-aging" sunscreens, effectively neutralizing free radicals that contribute to skin aging.
  • OS-01 BODY SPF targets intrinsic aging at the cellular level with its OS-01 peptide and combats extrinsic aging factors through broad-spectrum UV protection and antioxidants.
  • Designed to be lightweight and blend seamlessly without the typical chalky texture or white cast associated with mineral sunscreens, OS-01 BODY SPF has been well-received by users across various skin tones, demonstrating high usability and compatibility.
  • The formulation offers triple-action protection from UV rays, collagen degradation, and cellular aging, making it a cutting-edge solution for maintaining youthful skin and reversing signs of aging.
References
  1. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
  2. https://www.nature.com/articles/s41514-023-00109-1
  3. https://pubmed.ncbi.nlm.nih.gov/8042567/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322554/
  6. https://pubmed.ncbi.nlm.nih.gov/21255091/
  7. https://pubmed.ncbi.nlm.nih.gov/19319493/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120804/
References
  1. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
  2. https://www.nature.com/articles/s41514-023-00109-1
  3. https://pubmed.ncbi.nlm.nih.gov/8042567/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322554/
  6. https://pubmed.ncbi.nlm.nih.gov/21255091/
  7. https://pubmed.ncbi.nlm.nih.gov/19319493/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120804/