Complete Skin Longevity Regimen
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- Format Gel cleanser, rich eye cream, lightweight facial moisturizer, nourishing body moisturizer, hydrating sunscreen
- Targets Dullness, dehydration, crepiness, skin barrier function, wrinkles, UV-induced skin aging
- Suited to All skin types, safe for sensitive skin
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This total skin health routine is everything you need to cleanse, restore, strengthen, and protect your skin at the cellular level. Begin with PREP to gently cleanse away impurities and prime skin for optimal penetration of the OS-01 peptide01. Then apply OS-01 EYE, which is specially formulated for the delicate skin around the eyes and scientifically proven to boost collagen levels by up to 2.3x01. Next, OS-01 FACE goes to work tackling cellular aging, leaving skin more elastic and hydrated.02 Finally, our daily mineral SPF OS-01 SHIELD prevents UV-damage with non-nano zinc oxide while targeting intrinsic aging with the OS-01 peptide03. Complete your routine with OS-01 BODY to improve dry, crepey, and sagging skin below the neck, strengthening the skin’s natural barrier by up to 41%01.
Benefits
Everything you need to cleanse, hydrate, nourish, and protect your skin in one routine
Radiance
PREP gently exfoliates to slough away dullness and reveal brighter, healthier-looking skin.
Hydration
Topical supplements strengthen the skin barrier, allowing for better moisture retention and hydration.02,04
UV protection
OS-01 FACE SPF protects skin from UV damage, free radicals, and the effects of past aging.01
OS-01 FACE
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
OS-01 EYE
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
OS-01 BODY
See why customers love OS-01 BODY
“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.
"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.
"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.
OUR APPROACH
Results that go beyond the lab
9
Years of Research
900
Peptides Screened
18
Patents & Publications
9000
5-Star Reviews
The science behind the Complete Skin Longevity Regimen
Active ingredients that complement the OS-01 peptide
-
Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.
Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.
Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.
Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.
Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.
Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
OS-01 EYE
How to apply OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger.
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
- Use 2 times daily.
OS-01 FACE
How to apply OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers.
- Gently massage into skin on the face and neck.
- Use 2 times daily.
OS-01 BODY
How to apply OS-01 BODY
Follow these easy steps for optimal results
- Apply to arms, legs, chest, back, and stomach.
- Massage until absorbed.
- Use 2 times daily.
OS-01 FACE SPF
How to apply OS-01 FACE SPF
Follow these easy steps for optimal results
- Apply to the face and neck.
- Massage into skin until absorbed.
- Use 15 minutes prior to sun exposure and reapply every two hours.
How it works
Powered by the OS-01 Senescence Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level 03,07
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
Complete Skin Longevity Regimen
- olivia b.Verified BuyerReviewingComplete Skin Longevity Regimen UntintedI recommend this productRated 5 out of 5 starscomplete in the the most perfectly shortest way possible
not advertised for it , but CURED my terrible cystic acne in 2 days. im still shocked by it but 1000/10 recommend !!!
- Janet V.Verified BuyerReviewingOS-01 BODY Topical SupplementI recommend this productRated 5 out of 5 starsIt actually works
I have tried every cream possible to get rid of my scaly dry skin on my legs. This is the only cream that has finally worked. After a month of using my skin is unbelievably smooth. Try it you won’t be disappointed.
- Dyan M.Verified BuyerReviewingOS-01 BODY Topical SupplementI recommend this productRated 5 out of 5 starsLove!
Love this product. So luxurious. Not too thin or thick. and you don't need a lot. Feels so good and the best part it works! I haven't had my dry legs look this good in a long time. Even my hubby commented on it. My legs feel and look so much smoother. Putting it on my arms next.
- Cathi K.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 starsBetter skin
I have been using One Skin for a few years now and my skin is maintaining youthfulness without the need for a lot of costly spa treatments. I feel that my skin's hydration level and tone continue to improve with daily use. I love it.
- Dyan M.Verified BuyerRated 5 out of 5 starsSuper Nice
I can't believe how quickly OneSkin Creams absorb and this face cream is no exception. Love the feel of my skin and seeing my skin looking smoother and firmer already. Can't wait to see the results after a few months. Also, the support team with this company is exceptional. They get back to you with any problem you may have, because they care about you and your skin. Plus, the website is one of the easiest I have found to navigate and super easy to subscribe, unsubscribe, hold an order, cancel an order, change your subscribe dates etc. Just with a click of a button it's done. Give it a try. You won't be disappointed.
