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Face

OS-01 FACE Topical Supplement

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  • Targets Dehydration, dullness, loss of elasticity
  • Suited to All skin types, safe for sensitive skin
  • Format Lightweight moisturizer

OS-01 FACE is a daily skin longevity treatment with the OS-01 Senescence Blocking Peptideβ„’, scientifically proven to target a root cause of skin aging to promote healthy, youthful skin on the face and neck.01,02

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

β€œI stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

CLINICAL DATA

Visible results, scientifically validated

100

of participants had improved smoothness 02

95.5

of participants had improved firmness, radiance, and tone 02

90

of participants had improved elasticity 02

86

of participants had improved appearance of fine lines and wrinkles 02

The Science Behind OS-01 FACE

With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:

  1. Increases epidermal thickness 01
  2. Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,03
  3. Promotes cellular proliferation (increase in MKI67) 01


Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Peptideβ„’

The only peptide scientifically proven to reverse skin aging at the cellular levelΒ 01,02,03

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age Β  and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 5,564 reviews
Total 5 star reviews: 4.5k Total 4 star reviews: 736 Total 3 star reviews: 232 Total 2 star reviews: 65 Total 1 star reviews: 56
94%would recommend these products
5,564 reviews
  • JJ
    Jennifer J.
    Verified Buyer
    Reviewing
    Replacement OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    7 hours ago
    Real deal

    I love this moisturizer! I’ve been using it for almost a year now & it really works great. I’m in my 40s and suits my skin perfectly. Recommend this for your everyday face lotion .

  • JI
    John I.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    13 hours ago
    OS-01 face wash

    I've been using the OneSkin OS-01 Face Wash for over a year and love it. I appreciate that it is "pricey", but it’s gentle yet effective, cleansing without drying my skin is priceless. The gel texture feels refreshing, and it leaves my skin smooth, clear, and prepped for the rest of my routine. Perfect for sensitive skin and a great complement to anti-aging care. JMI - 4-23-2025

  • M
    Michelle
    Verified Reviewer
    Reviewing
    OS-01 FACE Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    THE BEST product I have ever used

    I have never written a review for a product, ever! One night when I had insomnia I was listening to a podcast and I heard one of the founder’s of OneSkin being interviewed. She mentioned that One Skin is endorsed by the eczema association. I have sensitive skin and eczema so I decided to give it a try. I have since bought every product in the line. I have recommended it to countless people and the other night we went out to dinner with friends . My friend text me after dinner and said β€œ I meant to ask you what you are using on your face. Is it some magical facial I should know about?. My old hands look younger and my skin is glowing. I can’t stop talking about these products.

    As I said , I have never written a review for anything . I highly recommend everything that One Skin has to offer.

  • RG
    Robby G.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Amazing!

    Great product, feels good, looks good and makes my routine so easy, I’m a man and I can say it’s great for all skin types. Highly recommend

  • VJ
    Vianey J.
    Verified Buyer
    Reviewing
    OS-01 FACE Topical Supplement Refill
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Easy, practical and green-friendly!

    Very pleased with this product and the practical replacement. I also appreciate that it’s green-friendly!