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BEST SELLERS SET

4.8
4.8 out of 5
4.8 out of 5
(5,349)

Hydrating face and eye care that smooths + firms.

  • Age-Reversal Peptide
  • Smoothing
  • Firming
  • Fragrance Free
One Skin eye cream bottle and packaging on a beige background
Two cream product swatches on a solid black background, labeled '05-01 FACE MOISTURIZER' and '05-01 EYE CREAM' in white text with a small red square.
Two skincare bottles from ONE SKIN on a white grid background with marketing text. The larger bottle is white with a black cap and black logo, and the smaller bottle is a clear glass bottle with a black pump and white label.
Before-and-after comparison of facial skin texture on the forehead, showing deep wrinkles and hyperpigmentation in the top panel labeled BEFORE, and smoother, clearer skin in the bottom panel labeled AFTER 12 WEEKS. Text on the right states '100% showed visibly smoother skin'.
Before-and-after comparison of an eye cream treatment on a person's eye area, showing skin texture and elasticity improvement over 12 weeks. The top panel is labeled 'BEFORE' and the bottom panel 'AFTER 12 WEEKS' with text stating '26% increase in elasticity'.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Two ONE SKIN skincare bottles, a smaller black pump bottle and a larger white cylindrical container, displayed on a black surface with a gray gradient background and scientific props including a microscope and petri dish.
One Skin eye cream bottle and packaging on a beige background
Two cream product swatches on a solid black background, labeled '05-01 FACE MOISTURIZER' and '05-01 EYE CREAM' in white text with a small red square.
Two skincare bottles from ONE SKIN on a white grid background with marketing text. The larger bottle is white with a black cap and black logo, and the smaller bottle is a clear glass bottle with a black pump and white label.
Before-and-after comparison of facial skin texture on the forehead, showing deep wrinkles and hyperpigmentation in the top panel labeled BEFORE, and smoother, clearer skin in the bottom panel labeled AFTER 12 WEEKS. Text on the right states '100% showed visibly smoother skin'.
Before-and-after comparison of an eye cream treatment on a person's eye area, showing skin texture and elasticity improvement over 12 weeks. The top panel is labeled 'BEFORE' and the bottom panel 'AFTER 12 WEEKS' with text stating '26% increase in elasticity'.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Two ONE SKIN skincare bottles, a smaller black pump bottle and a larger white cylindrical container, displayed on a black surface with a gray gradient background and scientific props including a microscope and petri dish.

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  • Certified cruelty-freeby The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-freeby The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-freeby The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Smooth, visibly firm, and improve visible signs of aging with a hydrating duo for the face and eye area, powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 FACE MOISTURIZER visibly smooths and softens texture, evens skin tone, and strengthens skin’s protective barrier1
  • OS-01 EYE CREAM improves elasticity and firmness while smoothing the appearance of fine lines and wrinkles2,3 
  • Lightweight textures instantly absorb into skin with no residue
Clinical proof

OS-01 FACE MOISTURIZER

  • 100% showed visibly smoother texture after 12 weeks1
  • 96% showed more even tone, radiance, and visible firmness after 12 weeks1
  • 91% had improved elasticity after 12 weeks1

OS-01 EYE CREAM

  • +26% increase in elasticity after 3 months2
  • +27% increase in visible firmness after 12 months3
  • -18% reduction in the appearance of fine lines and wrinkles after 12 months3

The Clinical Studies

OS-01 FACE MOISTURIZER: 3-Month Efficacy Study1

A 12-week, third-party split-face, double-blind clinical study evaluated the effects of OS-01 FACE and the OS-01 Peptide™ in 22 female participants (ages 47–65) with dry, normal, and combination skin. Participants applied OS-01 FACE MOISTURIZER 2x daily to one side of the face and an identical peptide-free "vehicle" formula to the other, isolating the peptide's effect from the rest of the formulation. Barrier function, wrinkles, texture, and radiance were measured with instrumental devices (Vapometer, Antera 3D, VISIA CR), while fine lines/wrinkles, skin tone, texture, firmness, elasticity, radiance, and overall appearance were evaluated visually and tactiley by expert clinical graders. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2024.

The results after 12 weeks:

  • 100% showed visibly smoother skin with improved overall appearance (blind expert grading)
  • 96% showed more even, radiant, and firmer-looking skin with less visible pores (blind expert grading)
  • 91% showed improved elasticity (blind expert grading)
  • 86% had reduced appearance of fine lines and wrinkles (blind expert grading)
  • +14% increase in barrier strength (Tewameter)
  • +17% improvement in visible radiance (VISIA-CR)

OS-01 EYE CREAM: 3-Month Efficacy Study2 

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 3 months in 22 participants aged 47–65. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under-eye puffiness, and dark circles. The study has been published in the International Journal of Cosmetic Science.

Measured results:

  • +20 increase in hydration after 1 month; +32% increase in hydration after 3 months (Corenometer)
  • +14% increase in elasticity after 1 month; +26% increase in elasticity after 3 months (Cutometer)
  • +10% increase in firmness after 3 months (Cutometer)
  • +10% increase in barrier strength after 1 month; +17% increase in barrier strength after 3 months (Vapometer)

Consumer perception results:

  • 95% observed improved overall appearance after 3 months
  • 91% observed visibly more even tone and smoother texture after 3 months
  • 86% observed more radiant skin after 3 months
  • 82% observed visible improvements in firmness and elasticity after 3 months
  • 77% observed reduced visible eye puffiness after 3 months

OS-01 EYE CREAM: 12-Month Efficacy Study3

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 12 months in 23 participants aged 47–60. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily and results were assessed by expert clinical grading.

Expert Grading Results:

  • +19% increase in visible firmness after 6 months; +27% increase in visible firmness after 12 months (expert grading)
  • +23% increase in visible elasticity after 6 months; +29% increase in elasticity after 12 months (expert grading)
  • 18% reduction in the appearance of fine lines and wrinkles after 12 months (expert grading)

Consumer perception results:

  • 100% observed improved overall appearance after 12 months
  • 100% observed more radiant skin after 12 months
  • 96% observed visibly more even tone and smoother texture after 12 months
  • 95% observed improved firmness and elasticity after 12 months
  • 86% observed reduced appearance of eye bags after 12 months
  • 86% observed reduced appearance of visible dark spots after 12 months

Safety studies

OS-01 FACE MOISTURIZER and OS-01 EYE CREAM are non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on their formulas and clinical testing, they have been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE MOISTURIZER ingredients:
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 EYE CREAM ingredients:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

This set includes

Clear bottle with black pump and 'One Skin' label on a light beige background

STEP 1

OS-01 EYE CREAM

Nourishing hydration that improves elasticity + firmness.

Size

20 mL / .67 fl oz

How to use

Gently tap 1⁄2-1 pump around each eye.

Skincare bottle labeled 'One Skin' on a beige background

STEP 2

OS-01 FACE MOISTURIZER

Lightweight hydration clinically shown to firm and smooth skin.

Size

50 mL / 1.7 fl oz

How to use

Gently massage 1-2 pumps into the face, neck, and chest.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.4

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time

Before-and-after comparison of under-eye dark circles on a person's face, with the top labeled BEFORE and the bottom labeled AFTER 12 WEEKS. The image shows close-up views of the left eye area with a dotted circle highlighting the skin region.

95%

reported smoother-looking and more even-toned skin after 4 weeks2

Before-and-after comparison of a person's eye area showing skin texture and wrinkles around the eye, with text reading 'BEFORE' and 'AFTER 12 WEEKS' on a beige sidebar.

95%

reported improved overall appearance after 12 weeks2

Before-and-after comparison of a closed eye showing skin texture and wrinkles around the eyelid, with dotted white outlines highlighting the treated area. The top panel is labeled BEFORE and the bottom panel is labeled AFTER 12 WEEKS.

86%

had improved elasticity after 12 weeks2

Clinically validated results that build over time

WEEK 1

Instant hydration you can feel 

  • OS-01 Peptide™  gets to work reversing the visible effects of senescent (dysfunctional, aging) cells
  • Supporting ingredients instantly hydrate and smooth
  • Caffeine visibly stimulates circulation
month 1

Visibly smoother, firmer, more-even-toned skin

  • +20% boost in hydration2
  • 95% observed visibly smoother texture and a more even tone2
  • 86% observed improvements in visible firmness and elasticity2
month 12

Visibly healthier, firmer skin that looks, feels + acts younger

  • +27% improvement in visible firmness3
  • +29% improvement in visible elasticity3
  • -18% reduced appearance of fine lines and wrinkles
  • +25% improved radiance3
  • 95% saw improvements in general appearance3

Key ingredients

A thick, creamy white swatch of cosmetic cream or lotion on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Moringa oleifera seed extract

Protects skin cells against environmental pollutants that can trigger visible skin aging.

Biomimetic vegan collagen

This biodesigned vegan collagen peptide visibly boosts elastin, laminin, collagen and fibronectin while most topical collagen fails to reach the deeper layers. 

Fucus vesiculosus algae

Helps reduce the appearance of dark circles and crow’s feet while enhancing overall skin luminosity.

All ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE MOISTURIZER ingredients:
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 EYE CREAM ingredients:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

OneSkin Longevity Protocol

BEST SELLERS SET

Write a Review (Opens in a new window)
5,349 reviews
  • LT
    Lori T.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch, Replacement
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    10 stars

    I love the one skin tropical supplement. It has even out my skin. I typically am an oily girl, and my tea zones are so balanced. I would recommend this product to any age.

    Was this helpful?
  • AM
    Amy M.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    14 hours ago
    Face cream

    Been using the body lotion for almost a year and love it. Thought I would try the face cream and already loving results

    Was this helpful?
  • JV
    Jennifer V.
    Verified Buyer
    Reviewing
    OS-01 EYE CREAM Refill
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    Eye Cream

    I am constantly being asked what I use for skincare. All the other products I have tried over the years and no one has ever asked me that until I started using One Skin. I love the product!

    Was this helpful?
  • TS
    Tracey S.
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    Love it

    Absorbs completely and makes face so soft!

    Was this helpful?
  • DM
    Debbie M.
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Love all of One Skin products.

    I decided to switch from OneSkin to a popular Korean skincare. After about 3 months I switched back to One Skin and will never switch back again! I use the prep, eye, skin, and body and love them all. They make my 61 year old skin look great!! ❤️

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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.) 
  2. Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025.) 
  3. Based on a third-party 12-month clinical study with 23 participants aged 47–60.
  4. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)