Head-to-Toe Skin Health Trio
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- Format Rich eye cream, lightweight facial moisturizer, nourishing body moisturizer
- Targets Dehydration, thinning skin, loss of elasticity, dullness, barrier function
- Suited to All skin types, safe for sensitive skin
Benefits
Everything you need to cleanse, hydrate, nourish, and protect your skin in one routine
Radiance
PREP gently exfoliates to slough away dullness and reveal brighter, healthier-looking skin.
Hydration
Topical supplements strengthen the skin barrier, allowing for better moisture retention and hydration.03,04
UV protection
OS-01 FACE SPF protects skin from UV damage, free radicals, and the effects of past aging.01
OS-01 FACE
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
OS-01 EYE
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
OS-01 BODY
See why customers love OS-01 BODY
“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.
"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.
"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.
OUR APPROACH
Results that go beyond the lab
9
Years of Research
900
Peptides Screened
18
Patents & Publications
9000
5-Star Reviews
The science behind the Head-to-Toe Skin Health Trio
With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:
01 Increases epidermal thickness 02
02 Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,02
03 Promotes cellular proliferation (increase in MKI67) 02
Active ingredients that complement the OS-01 peptide
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Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.
Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.
Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.
Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.
Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.
Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
OS-01 EYE
How to apply OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger.
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
- Use 2 times daily.
OS-01 FACE
How to apply OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers.
- Gently massage into skin on the face and neck.
- Use 2 times daily.
OS-01 BODY
How to apply OS-01 BODY
Follow these easy steps for optimal results
- Apply to arms, legs, chest, back, and stomach.
- Massage until absorbed.
- Use 2 times daily.
How it works
Powered by the OS-01 Senescence Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level 02,07
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
03 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
Head-to-Toe Skin Health Trio
- Angela R.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 starsBest product for eyes, neck and hands
The One skin EYE cream is the most effective wrinkle reducer I have ever tried. I use this product around and on my upper lids, my neck and the back of each hand. I have been using this product for 8 months and love it. Where I notice the most youthful collagen building effect is on my hands and the corners of my eyes.
- na n.Verified BuyerReviewingOS-01 BODY Topical SupplementI recommend this productRated 5 out of 5 starsgreat
started with. my first bottle and i realy like it
- Ashley Rose L.Verified BuyerReviewingOS-01 EYE Topical SupplementI recommend this productRated 4 out of 5 starsGreat
I've only been using it a couple weeks but I do believe I see a difference. Skin around the eye feels a little tighter and smoother. Eyes feel better
OneSkin11 hours agoHi Ashley!
Thank you for your review! We are happy to hear you are enjoying OS-01 EYE!
- GinaReviewingOS-01 BODYI recommend this productRated 5 out of 5 stars5 Stars
I love how hydrated my skin is after applying it, without a greasy or sticky residue. Even better, I’m noticing a renewed firmness to my skin.
- MelissaReviewingOS-01 BODY Topical SupplementI recommend this productRated 5 out of 5 stars5 Stars
I am surprised at how much better my skin looks after using this OneSkin Body lotion. It REALLY works on my “aging” skin! Give it a try you won’t be disappointed 😊
