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HEAD-TO-TOE SKIN HEALTH DUO

4.7
4.7 out of 5
4.7 out of 5
(7,751)

Hydrating face and body care that smooths + firms.

  • Age-Reversal Peptide
  • Smoothing
  • Firming
  • Fragrance Free
head to toe skin health duo
Two smooth, glossy white cream swatches on a solid black background, labeled 'OS-01 FACE MOISTURIZER' and 'OS-01 BODY MOISTURIZER' in white text.
HEAD-TO-TOE SKIN HEALTH DUO
HEAD-TO-TOE SKIN HEALTH DUO
HEAD-TO-TOE SKIN HEALTH DUO
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
HEAD-TO-TOE SKIN HEALTH DUO
head to toe skin health duo
Two smooth, glossy white cream swatches on a solid black background, labeled 'OS-01 FACE MOISTURIZER' and 'OS-01 BODY MOISTURIZER' in white text.
HEAD-TO-TOE SKIN HEALTH DUO
HEAD-TO-TOE SKIN HEALTH DUO
HEAD-TO-TOE SKIN HEALTH DUO
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
HEAD-TO-TOE SKIN HEALTH DUO

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Smooth, visibly firm, and improve visible signs of aging with a hydrating duo for the face and body, powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 FACE MOISTURIZER visibly smooths and softens texture, evens skin tone, and strengthens skin's protective barrier1
  • OS-01 BODY MOISTURIZER targets a root cause of crepiness while visibly firming for younger-looking, healthier body skin2
  • Lightweight textures instantly absorb into skin with no residue
Clinical proof

OS-01 FACE MOISTURIZER

  • 100% showed visibly smoother texture after 12 weeks¹
  • 96% showed more even tone, radiance, and visible firmness after 12 weeks¹
  • 91% had improved elasticity after 12 weeks¹

OS-01 BODY MOISTURIZER

  • +41% increase in skin's barrier resilience after 12 weeks²
  • +38% increase in hydration after 12 weeks²
  • 70% reported visibly smoother texture and improved general appearance²

The Clinical Studies

OS-01 FACE MOISTURIZER Efficacy Study — Published in the Journal of Cosmetic Dermatology

A 12-week, third-party split-face, double-blind clinical study evaluated the effects of OS-01 FACE and the OS-01 Peptide™ in 22 female participants (ages 47–65) with dry, normal, and combination skin. Participants applied OS-01 FACE MOISTURIZER 2x daily to one side of the face and an identical peptide-free "vehicle" formula to the other, isolating the peptide's effect from the rest of the formulation. Barrier function, wrinkles, texture, and radiance were measured with instrumental devices (Vapometer, Antera 3D, VISIA CR), while fine lines/wrinkles, skin tone, texture, firmness, elasticity, radiance, and overall appearance were evaluated visually and tactilely by expert clinical graders. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2024.

The results after 12 weeks1:

  • 100% showed visibly smoother skin with improved overall appearance (blind expert grading)
  • 96% showed more even, radiant, and firmer-looking skin with less visible pores (blind expert grading)
  • 91% showed improved elasticity (blind expert grading)
  • 86% had reduced appearance of fine lines and wrinkles (blind expert grading)
  • +14% increase in barrier strength (Tewameter)
  • +17% improvement in visible radiance (VISIA-CR)

Safety studies

OS-01 FACE MOISTURIZER is non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on its formula and clinical testing, it has been awarded the National Eczema Association Seal of Acceptance™.

OS-01 BODY MOISTURIZER Efficacy Study — Published in the Journal of Cosmetic Dermatology

A 12-week, double-blind, third-party clinical study evaluated the effects of OS-01 BODY MOISTURIZER on body skin hydration, barrier function, texture, and appearance. 60 participants were divided into two groups: one applied OS-01 BODY twice daily, while the other applied a placebo moisturizer twice daily. Hydration and trans-epidermal water loss (TEWL) were measured with instrumental devices (Corneometer and Tewameter). Participants also reported subjective improvements. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2025.

The results after 12 weeks1:

  • 93% of participants reported improved skin hydration
  • +38% improvement in forearm and upper arm hydration (corneometer)
  • +41% improvement in skin barrier on forearm and +35% on upper arm (tewameter)
  • 70% reported improved skin texture
  • 70% reported improved overall appearance

Safety studies

OS-01 BODY MOISTURIZER is non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on its formula and clinical testing, it has been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE MOISTURIZER ingredients:
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.


OS-01 BODY MOISTURIZER ingredients:
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin,  Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

This set includes

Skincare bottle labeled 'One Skin' on a beige background

STEP 1

OS-01 FACE MOISTURIZER

Lightweight hydration clinically shown to firm and smooth skin.

Size

50 mL / 1.7 fl oz

How to use

Gently massage 1-2 pumps into the face, neck, and chest.

White bottle with black pump and 'One Skin' logo on a beige background

STEP 2

OS-01 BODY MOISTURIZER

Nourishing hydration designed to strengthen crepey skin.

Size

250 mL / 8.45 fl oz

How to use

Apply to arms, legs, chest, back, and stomach and massage until absorbed. Use 2x daily.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.3

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time

Side-by-side close-up of an older woman's eye area labeled 'BEFORE' and 'AFTER 12 WEEKS,' showing skin texture and wrinkle improvement with dotted white outlines highlighting treated areas.

100%

showed smoother-looking skin in 12 weeks1

A side-by-side close-up comparison of an older person's eye and surrounding skin, labeled 'BEFORE' on the left and 'AFTER 12 WEEKS' on the right, showing visible skin improvement.

96%

had improved visible firmness, radiance, and tone after 12 weeks1

A side-by-side before and after comparison of an older woman's eye and cheek area, showing skin texture and wrinkles. The left panel is labeled 'BEFORE' and the right panel is labeled 'AFTER 12 WEEKS'.

91%

had improved elasticity after 12 weeks1

A side-by-side close-up comparison of an older person's eye and forehead, labeled 'BEFORE' on the left and 'AFTER 12 WEEKS' on the right, showing reduced wrinkles and sun damage over 12 weeks.

86%

showed reduced appearance of fine lines and wrinkles after 12 weeks1

Week 1

Instant hydration you can feel

  • The OS-01 Peptide™ gets to work reversing the visible effects of senescent (dysfunctional, aging) cells
  • Supporting ingredients instantly hydrate
  • Skin feels soft, plump, and nourished
Week 6

Visibly smoother, firmer, more resilient skin

  • +19% improvement in barrier strength1
  • 91% showed visibly firmer skin1
  • 86% showed smoother-looking skin1
Week 12

Visibly healthier skin that looks, feels + acts younger

  • 100% showed visibly firmer skin1
  • 96% showed more radiant, even-toned, firmer-looking skin1
  • 91% showed improved elasticity1

Key ingredients

A thick, creamy white swatch of cosmetic cream or lotion on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Hyaluronic acid

Three molecular weights hydrate each layer of the skin.

Niacinamide

Improves skin tone and fortifies the barrier for a smoother, more even-looking texture.

Oleic pau mulato extract

An Amazonian antioxidant that minimizes visible signs of skin stress and supports skin’s natural repair processes.

Pracaxi oil

A nourishing Amazonian oil that provides potent antioxidant support and deep moisturization.

Andiroba oil

A lightweight, nourishing oil rich in fatty acids that supports the look of natural collagen and soothes skin.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE MOISTURIZER ingredients:
Ingredients
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.


OS-01 BODY MOISTURIZER ingredients:
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin,  Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

OneSkin Longevity Protocol

HEAD-TO-TOE SKIN HEALTH DUO

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7,751 reviews
  • KG
    Kelly G.
    Verified Buyer
    Reviewing
    HEAD-TO-TOE SKIN HEALTH DUO
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    So far so good

    I am 62 and the creepy skin on my bicep area is actually starting to look better and it’s only been a few weeks. The jury is still out on the face cream but I think my lines are softening a bit so I am going to keep my subscription going and give it a full 6 months to really work.

    Was this helpful?
  • LT
    Lori T.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch, Replacement
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    10 stars

    I love the one skin tropical supplement. It has even out my skin. I typically am an oily girl, and my tea zones are so balanced. I would recommend this product to any age.

    Was this helpful?
  • KC
    Kathryn C.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    13 hours ago
    So good

    This stuff is amazing. A little goes a long way and my skin drinks it right up.

    Was this helpful?
  • AM
    Amy M.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    16 hours ago
    Face cream

    Been using the body lotion for almost a year and love it. Thought I would try the face cream and already loving results

    Was this helpful?
  • RW
    Raelene W.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    17 hours ago
    One Skin body Moisturizer

    I Love this moisturizer ! My skin has never felt better . Its alittle pricey but worth it

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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)
  2. Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025.)
  3. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)