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Younger, healthier skin starts at the cellular level

Meet OS-01, the first peptide proven to target a root cause of skin agingβ€”cellular senescence. 01

OneSkin

OUR APPROACH

The real proof? It’s in the numbers.

9

years of research

900

peptides screened

18

patents & publications

9000

5-Star Reviews

OUR BREAKTHROUGH PEPTIDE

OS-01: the new standard in peptide technology

Think of OS-01 as a reset button for your skin, helping clear away the senescent cells that cause wrinkles, hyperpigmentation, and crepiness. As the first peptide scientifically proven to reduce cellular senescence in the skin, OS-01 does what other peptides can’t. 01

DAILY ESSENTIALS

The 5-minute skin health routine

Frequently Asked Questions

OneSkin

Peptides are short chains of amino acids. They represent a broad class of molecules with many jobs, from forming the building blocks of larger proteins to acting as cellular messengers. Peptides found naturally in the body (called endogenous peptides), play a crucial role in tissue growth, hormone regulation, and other biological processes. Exogenous peptides, which can be injected, ingested or delivered topically like OS-01, can send out signals to skin cells to trigger collagen and hyaluronic acid production, aid in cellular repair, and help strengthen the skin barrier.01,02,03

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age Β  and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

OneSkin
PHILANTHROPY

Propelled by a shared mission to
change the way humans experience aging

We donate a portion of sales to the Aging Forward (formerly Shepherd's Center of America), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning.